The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Vitamin E in Humans: Demand and Delivery
Abstract
How much vitamin E is enough? An established use of supplemental vitamin E in humans is in the prevention and therapy of deficiency symptoms. The cause of vitamin E deficiency, characterized by peripheral neuropathy and ataxia, is usually malabsorption—a result of fat malabsorption or genetic abnormalities in lipoprotein metabolism. Genetic abnormalities in the hepatic α-tocopherol transfer protein also cause vitamin E deficiency—defects in this protein cause an impairment in plasma vitamin E transport. Impaired delivery of vitamin E to tissues, thereby, results in deficiency symptoms. Also discussed is the use of supplemental vitamin E in chronic diseases such as ischemic heart disease, atherosclerosis, diabetes, cataracts, Parkinson's disease, Alzheimer's disease, and impared immune function, as well as in subjects receiving total parenterol nutrition. In healthy individuals, a daily intake of about 15-30 mg of α-tocopherol is recommended to obtain “optimal plasma alpha-tocopherol concentrations” (30 μM or greater).
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Cites
Tolerance and safety of vitamin E: A toxicological position report
Kappus, H. (1992) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(92)90166-e · Cited by 239
Cited by
Iqbal, J., & Hussain, M. M. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90899.2008 · Cited by 811
Dietary Change and Traditional Food Systems of Indigenous Peoples
Kuhnlein, H. V., & Receveur, O. (1996) · Annual Review of Nutrition · doi:10.1146/annurev.nu.16.070196.002221 · Cited by 595
Antioxidant Therapy in Acute Central Nervous System Injury: Current State
Gilgun-Sherki, Y., Rosenbaum, Z., Melamed, E., & Offen, D. (2002) · Pharmacological Reviews · doi:10.1124/pr.54.2.271 · Cited by 568
(2007) · doi:10.1007/978-3-540-37885-3 · Cited by 476
Metadata
- Authors
- Traber, M. G., & Sies, H.
- Venue
- Annual Review of Nutrition
- Publisher
- Annual Reviews
- Published
- 1996-07
- Volume
- 16
- Issue
- 1
- Pages
- 321-347
- ISSN
- 0199-9885 (ISSN-L)
- 1545-4312
- OpenAlex
- W2157981391
- Cited by
- 502
- References
- 1
- FWCI
- 11.76
- Type
- journal article
- Language
- en
- Open access
- closed
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