The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Vitamin E in Humans: Demand and Delivery
Abstract
How much vitamin E is enough? An established use of supplemental vitamin E in humans is in the prevention and therapy of deficiency symptoms. The cause of vitamin E deficiency, characterized by peripheral neuropathy and ataxia, is usually malabsorption—a result of fat malabsorption or genetic abnormalities in lipoprotein metabolism. Genetic abnormalities in the hepatic α-tocopherol transfer protein also cause vitamin E deficiency—defects in this protein cause an impairment in plasma vitamin E transport. Impaired delivery of vitamin E to tissues, thereby, results in deficiency symptoms. Also discussed is the use of supplemental vitamin E in chronic diseases such as ischemic heart disease, atherosclerosis, diabetes, cataracts, Parkinson's disease, Alzheimer's disease, and impared immune function, as well as in subjects receiving total parenterol nutrition. In healthy individuals, a daily intake of about 15-30 mg of α-tocopherol is recommended to obtain “optimal plasma alpha-tocopherol concentrations” (30 μM or greater).
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Cites
Tolerance and safety of vitamin E: A toxicological position report
Kappus, H. (1992) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(92)90166-e · Cited by 239
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Self-citationVitamin E in human skin: Organ-specific physiology and considerations for its use in dermatology
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van den Berg, R., van Vliet, T., Broekmans, W. M. R., Cnubben, N. H. P., Vaes, W. H. J., Roza, L., Haenen, G. R. M. M., Bast, A., & van den Berg, H. (2001) · The Journal of Nutrition · doi:10.1093/jn/131.6.1714 · Cited by 144
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Self-citationOzone-exposure depletes vitamin E and induces lipid peroxidation in murine stratum corneum
Thiele, J. J., Traber, M. G., Polefka, T. G., Cross, C. E., & Packer, L. (1997) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12292144 · Cited by 123
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Oxidative Targets in the Stratum corneum
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Thiele, J. J., Traber, M. G., Podda, M., Tsang, K., Cross, C. E., & Packer, L. (1997) · FEBS Letters · doi:10.1016/s0014-5793(96)01463-9 · Cited by 79
Self-citationFrataxin: its role in iron metabolism and the pathogenesis of Friedreich's ataxia
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Lauridsen, C., Yong, C., Halekoh, U., Bügel, S. H., Brandt, K., Christensen, L. P., & Jørgensen, H. (2008) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.3142 · Cited by 28
Metadata
- Authors
- Traber, M. G., & Sies, H.
- Venue
- Annual Review of Nutrition
- Publisher
- Annual Reviews
- Published
- 1996-07
- Volume
- 16
- Issue
- 1
- Pages
- 321-347
- ISSN
- 0199-9885 (ISSN-L)
- 1545-4312
- OpenAlex
- W2157981391
- Cited by
- 502
- References
- 1
- FWCI
- 11.76
- Type
- journal article
- Language
- en
- Open access
- closed
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