The DOI matches its Crossref record; 96 of the 96 references it cites were found in a registry or an index.
NUTRITIONAL AND HORMONAL REGULATION OF ENZYMES IN FAT SYNTHESIS: Studies of Fatty Acid Synthase and Mitochondrial Glycerol-3-Phosphate Acyltransferase Gene Transcription
Abstract
▪ Abstract The activities of critical enzymes in fatty acid and triacylglycerol biosynthesis are tightly controlled by different nutritional, hormonal, and developmental conditions. Feeding previously fasted animals high-carbohydrate, low-fat diets causes a dramatic induction of enzymes—such as fatty acid synthase (FAS) and mitochondrial glycerol-3-phosphate acyltransferase (GPAT)—involved in fatty acid and triacylglycerol synthesis. During fasting and refeeding, transcription of these two enzymes is coordinately regulated by nutrients and hormones, such as glucose, insulin, glucagon, glucocorticoids, and thyroid hormone. Insulin stimulates transcription of the FAS and mitochondrial GPAT genes, and glucagon antagonizes the insulin effect through the cis-acting elements within the promoters and their bound trans-acting factors. This review discusses advances made in the understanding of the transcriptional regulation of FAS and mitochondrial GPAT genes, with emphasis on elucidation of the mechanisms by which multiple nutrients and hormones achieve their effects.
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FATTY ACID SYNTHESIS AND ITS REGULATION
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Cited by
Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis
Menendez, J. A., & Lupu, R. (2007) · Nature Reviews Cancer · doi:10.1038/nrc2222 · Cited by 2,941
Enzymes of triacylglycerol synthesis and their regulation
Coleman, R. (2004) · Progress in Lipid Research · doi:10.1016/s0163-7827(03)00051-1 · Cited by 965
Liang, G., Yang, J., Horton, J. D., Hammer, R. E., Goldstein, J. L., & Brown, M. S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111421200 · Cited by 669
Transcriptional regulation of hepatic lipogenesis
Wang, Y., Viscarra, J., Kim, S.-J., & Sul, H. S. (2015) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm4074 · Cited by 646
Self-citationUnsaturated Fatty Acids Down-regulate SREBP Isoforms 1a and 1c by Two Mechanisms in HEK-293 Cells
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Metadata
- Authors
- Sul, H. S., & Wang, D.
- Venue
- Annual Review of Nutrition
- Publisher
- Annual Reviews
- Published
- 1998-07
- Volume
- 18
- Issue
- 1
- Pages
- 331-351
- ISSN
- 0199-9885 (ISSN-L)
- 1545-4312
- OpenAlex
- W1946831939
- Cited by
- 280
- References
- 96
- FWCI
- 0.80
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: NUTRITIONAL AND HORMONAL REGULATION OF ENZYMES IN FAT SYNTHESIS: Studies of Fatty Acid Synthase and Mitochondrial Glycerol-3-Phosphate Acyltransferase Gene Transcription. https://app.cochat.ai/papers/10.1146/annurev.nutr.18.1.331
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- Sul, H. S., & Wang, D. (1998). NUTRITIONAL AND HORMONAL REGULATION OF ENZYMES IN FAT SYNTHESIS: Studies of Fatty Acid Synthase and Mitochondrial Glycerol-3-Phosphate Acyltransferase Gene Transcription. Annual Review of Nutrition. https://doi.org/10.1146/annurev.nutr.18.1.331
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