Transcriptional regulation of hepatic lipogenesis
Open accessAbstract
Fatty acid and fat synthesis in the liver is a highly regulated metabolic pathway that is important for very low-density lipoprotein (VLDL) production and thus energy distribution to other tissues. Having common features at their promoter regions, lipogenic genes are coordinately regulated at the transcriptional level. Transcription factors, such as upstream stimulatory factors (USFs), sterol regulatory element-binding protein 1C (SREBP1C), liver X receptors (LXRs) and carbohydrate-responsive element-binding protein (ChREBP) have crucial roles in this process. Recently, insights have been gained into the signalling pathways that regulate these transcription factors. After feeding, high blood glucose and insulin levels activate lipogenic genes through several pathways, including the DNA-dependent protein kinase (DNA-PK), atypical protein kinase C (aPKC) and AKT-mTOR pathways. These pathways control the post-translational modifications of transcription factors and co-regulators, such as phosphorylation, acetylation or ubiquitylation, that affect their function, stability and/or localization. Dysregulation of lipogenesis can contribute to hepatosteatosis, which is associated with obesity and insulin resistance.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
ChREBP is a member of the Mondo family of transcription factors, senses carbohydrates and activates genes involved in glycolysis, DNL, and lipid trafficking.
“ChREBP, which is a member of the Mondo family of transcription factors, senses carbohydrates and activates genes involved in glycolysis, DNL, and lipid trafficking [2,34,78].”
From Hepatic Insulin Resistance and Steatosis in Metabolic Dysfunction-Associated Steatotic Liver Disease: New Insights into Mechanisms and Clinical Implications (2025) · cites this paper as [34]
DNL is minimal during fasting but increases after a meal as glucose and insulin levels rise.
“DNL is minimal during fasting but increases after a meal as glucose and insulin levels rise, activating insulin signaling via PI3K, AKT, aPKC, mTORC, DNA-dependent protein kinase, and phosphatases [34,83].”
From Hepatic Insulin Resistance and Steatosis in Metabolic Dysfunction-Associated Steatotic Liver Disease: New Insights into Mechanisms and Clinical Implications (2025) · cites this paper as [34]
ChREBP expression decreased in the presence of severe IR.
“However, it decreased in the presence of severe IR [34,94].”
From Hepatic Insulin Resistance and Steatosis in Metabolic Dysfunction-Associated Steatotic Liver Disease: New Insights into Mechanisms and Clinical Implications (2025) · cites this paper as [34]
Hepatic steatosis is not necessarily accompanied by IR in DNL in the liver and can be initiated by factors other than insulin signaling.
“This result also demonstrates that hepatic steatosis is not necessarily accompanied by IR in DNL in the liver and can be initiated by factors other than insulin signaling [34].”
From Hepatic Insulin Resistance and Steatosis in Metabolic Dysfunction-Associated Steatotic Liver Disease: New Insights into Mechanisms and Clinical Implications (2025) · cites this paper as [34]
Insulin activates specific kinases and phosphatases that can modify transcription factors such as USF, SREBP1c, ChREBP, and LXR, or regulate their expression.
“Thus, insulin activates specific kinases and phosphatases that can modify transcription factors such as upstream stimulatory factor (USF), SREBP1c, ChREBP, and liver X receptor (LXR), or regulate the expression of these transcription factors (Fig. 4) [34,83].”
From Hepatic Insulin Resistance and Steatosis in Metabolic Dysfunction-Associated Steatotic Liver Disease: New Insights into Mechanisms and Clinical Implications (2025) · cites this paper as [34]
ChREBP is activated by carbohydrate uptake.
“ChREBP, which is activated by carbohydrate uptake [9,34,78,83].”
From Hepatic Insulin Resistance and Steatosis in Metabolic Dysfunction-Associated Steatotic Liver Disease: New Insights into Mechanisms and Clinical Implications (2025) · cites this paper as [34]
ChREBP expression in liver biopsies from patients with MASH was two-fold higher when the histologic steatosis score was greater than 50% compared to those with less than 50%.
“In this regard, ChREBP expression in liver biopsies from patients with MASH was observed to be two-fold higher when the histologic steatosis score was greater than 50% compared to those with less than 50%.”
From Hepatic Insulin Resistance and Steatosis in Metabolic Dysfunction-Associated Steatotic Liver Disease: New Insights into Mechanisms and Clinical Implications (2025) · cites this paper as [34]
Monosaccharides activate ChREBP and other key lipogenic transcription factors-including SREBP1c, LXR, and PPARγ-via insulin-independent mechanisms.
“Supporting this perspective, monosaccharides have been shown to activate ChREBP and other key lipogenic transcription factors—including SREBP1c, LXR, and PPARγ—via insulin-independent mechanisms [34,70,83,86,99].”
From Hepatic Insulin Resistance and Steatosis in Metabolic Dysfunction-Associated Steatotic Liver Disease: New Insights into Mechanisms and Clinical Implications (2025) · cites this paper as [34]
Substrate-driven pathways as insulin-independent mechanisms contribute to elevated DNL and enhanced esterification of FFAs into hepatic TG.
“Additionally, substrate-driven pathways as insulin-independent mechanisms contribute to elevated DNL and enhanced esterification of FFAs into hepatic TG [34,70,85,86].”
From Hepatic Insulin Resistance and Steatosis in Metabolic Dysfunction-Associated Steatotic Liver Disease: New Insights into Mechanisms and Clinical Implications (2025) · cites this paper as [34]
VLDL assembly and secretion are upregulated by delivery of fatty acids released from insulin-resistant adipocytes, increased delivery of remnant triglyceride-fatty acid to the liver due to reduced peripheral lipolysis of chylomicron and VLDL triglyceride, and increased de novo lipogenesis.
“VLDL assembly and secretion are upregulated by (i) the delivery of FA released from insulin-resistant adipocytes, (ii) the increased delivery of remnant TG–FA to the liver due to reduced peripheral lipolysis of chylomicron and VLDL–TG, and (iii) the increased de novo lipogenesis55 (Figure 4).”
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival
Inoki, K., Zhu, T., & Guan, K.-L. (2003) · Cell · doi:10.1016/s0092-8674(03)00929-2 · Cited by 3,914 · see citing works
Energy Metabolism in the Liver
Rui, L. (2014) · Comprehensive physiology · doi:10.1002/cphy.c130024 · Cited by 2,258 · see citing works
An oxysterol signalling pathway mediated by the nuclear receptor LXRα
Janowski, B. A., Willy, P. J., Devi, T. R., Falck, J. R., & Mangelsdorf, D. J. (1996) · Nature · doi:10.1038/383728a0 · Cited by 1,754 · see citing works
Repa, J. J., Liang, G., Ou, J., Bashmakov, Y. K., Lobaccaro, J. A., Shimomura, I., Shan, B., Brown, M. S., Goldstein, J. L., & Mangelsdorf, D. J. (2000) · Genes & Development · doi:10.1101/gad.844900 · Cited by 1,693 · see citing works
Role of LXRs in control of lipogenesisPreprint
Schultz, J. R., Tu, H., Luk, A. Y., Repa, J. J., Medina, J. C., Li, L., Schwendner, S. W., Wang, S., Thoolen, M., Mangelsdorf, D. J., et al. (2000) · Genes & Development · doi:10.1101/gad.850400 · Cited by 1,673 · see citing works
Nakahata, Y., Kaluzova, M., Grimaldi, B., Sahar, S., Hirayama, J., Chen, D., Guarente, L. P., & Sassone-Corsi, P. (2008) · Cell · doi:10.1016/j.cell.2008.07.002 · Cited by 1,427 · see citing works
Genome-wide mapping of HATs and HDACs reveals distinct functions in active and inactive genes
Wang, Z., Zang, C., Cui, K., Schones, D. E., Barski, A., Peng, W., & Zhao, K. (2009) · Cell · doi:10.1016/j.cell.2009.06.049 · Cited by 1,344 · see citing works
mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway
Peterson, T. R., Sengupta, S., Harris, T. E., Carmack, A. E., Kang, S. A. W., Balderas, E., Guertin, D. A., Madden, K. L., Carpenter, A. E., Finck, B. N., et al. (2011) · Cell · doi:10.1016/j.cell.2011.06.034 · Cited by 1,233 · see citing works
Regulation of circadian behaviour and metabolism by REV-ERB-α and REV-ERB-β
Cho, H., Zhao, X., Hatori, M., Yu, R. T., Barish, G. D., Lam, M. T., Chong, L.-W., DiTacchio, L., Atkins, A. R., Glass, C. K., et al. (2012) · Nature · doi:10.1038/nature11048 · Cited by 1,037 · see citing works
Time for food: the intimate interplay between nutrition, metabolism, and the circadian clock
Asher, G., & Sassone-Corsi, P. (2015) · Cell · doi:10.1016/j.cell.2015.03.015 · Cited by 844 · see citing works
A Topoisomerase IIß-Mediated dsDNA Break Required for Regulated Transcription
Ju, B., Lunyak, V. V., Perissi, V., García-Bassets, I., Rose, D. W., Glass, C. K., & Rosenfeld, M. G. (2006) · Science · doi:10.1126/science.1127196 · Cited by 842 · see citing works
Shimano, H., Horton, J. D., Shimomura, I., Hammer, R. E., Brown, M. S., & Goldstein, J. L. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119248 · Cited by 842 · see citing works
Kim, J. B., Sarraf, P., Wright, M., Yao, K., Mueller, E., Solanes, G., Lowell, B. B., & Spiegelman, B. M. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1411 · Cited by 792 · see citing works
Iizuka, K., Bruick, R. K., Liang, G., Horton, J. D., & Uyeda, K. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401516101 · Cited by 786 · see citing works
Joseph, S. B., Laffitte, B. A., Patel, P. H., Watson, M. A., Matsukuma, K. E., Walczak, R., Collins, J. L., Osborne, T. F., & Tontonoz, P. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111041200 · Cited by 779 · see citing works
Li, S., Brown, M. S., & Goldstein, J. L. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0914798107 · Cited by 733 · see citing works
A circadian rhythm orchestrated by histone deacetylase 3 controls hepatic lipid metabolism
Feng, D., Liu, T., Sun, Z., Bugge, A., Mullican, S. E., Alenghat, T., Liu, X. S., & Lazar, M. A. (2011) · Science · doi:10.1126/science.1198125 · Cited by 701 · see citing works
Liang, G., Yang, J., Horton, J. D., Hammer, R. E., Goldstein, J. L., & Brown, M. S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111421200 · Cited by 669 · see citing works
Yecies, J. L., Zhang, H., Menon, S., Liu, S., Yecies, D. W., Lipovsky, A. I., Görgün, C. Z., Kwiatkowski, D. J., Hotamışlıgil, G. S., Lee, C., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.06.002 · Cited by 662 · see citing works
Tontonoz, P., Kim, J. B., Graves, R. A., & Spiegelman, B. M. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.8.4753-4759.1993 · Cited by 599 · see citing works
A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism
Herman, M. A., Peroni, O. D., Villoria, J., Schön, M. R., Abumrad, N. A., Blüher, M., Klein, S., & Kahn, B. B. (2012) · Nature · doi:10.1038/nature10986 · Cited by 599 · see citing works
Hepatic mTORC2 Activates Glycolysis and Lipogenesis through Akt, Glucokinase, and SREBP1c
Hagiwara, A., Cornu, M., Cybulski, N., Polak, P., Betz, C., Trapani, F., Terracciano, L., Heim, M. H., Rüegg, M. A., & Hall, M. N. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.03.015 · Cited by 551 · see citing works
Chen, G., Liang, G., Ou, J., Goldstein, J. L., & Brown, M. S. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0404297101 · Cited by 546 · see citing works
SIRT1 Deacetylates and Inhibits SREBP-1C Activity in Regulation of Hepatic Lipid Metabolism*
Ponugoti, B., Kim, D.-H., Xiao, Z., Smith, Z., Miao, J., Zang, M., Wu, S.-Y., Chiang, C., Veenstra, T. D., & Kemper, J. K. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.122978 · Cited by 545 · see citing works
Viollet, B., Foretz, M., Guigas, B., Horman, S., Dentin, R., Bertrand, L., Hue, L., & Andréelli, F. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.108506 · Cited by 529 · see citing works
Yoshikawa, T., Shimano, H., Amemiya-Kudo, M., Yahagi, N., Hasty, A. H., Matsuzaka, T., Okazaki, H., Tamura, Y., Iizuka, Y., Ohashi, K., et al. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.9.2991-3000.2001 · Cited by 526 · see citing works
The nuclear receptor LXR is a glucose sensor
Mitro, N., Mak, P. A., Vargas, L., Godio, C., Hampton, E. N., Molteni, V., Kreusch, A., & Sáez, E. (2006) · Nature · doi:10.1038/nature05449 · Cited by 525 · see citing works
FoxO1 Regulates Multiple Metabolic Pathways in the Liver
Zhang, W., Patil, S., Chauhan, B., Guo, S., Powell, D. R., Le, J., Klotsas, A., Matika, R. W., Xiao, X., Franks, R. R., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m600272200 · Cited by 517 · see citing works
Rev-erbα and Rev-erbβ coordinately protect the circadian clock and normal metabolic functionPreprint
Bugge, A. K., Feng, D., Everett, L. J., Briggs, E. R., Mullican, S. E., Wang, F., Jager, J., & Lazar, M. A. (2012) · Genes & Development · doi:10.1101/gad.186858.112 · Cited by 503 · see citing works
Giguère, V., Tini, M., Flock, G. B., Ong, E. S., Evans, R. M., & Otulakowski, G. (1994) · Genes & Development · doi:10.1101/gad.8.5.538 · Cited by 488 · see citing works
The Liver X Receptor (LXR) and Hepatic Lipogenesis
Cha, J.-Y., & Repa, J. J. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m605023200 · Cited by 474 · see citing works
Shimano, H., Shimomura, I., Hammer, R. E., Herz, J., Goldstein, J. L., Brown, M. S., & Horton, J. D. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119746 · Cited by 447 · see citing works
Stiles, B., Wang, Y., Stahl, A., Bassilian, S., Lee, W. P., Kim, Y.-J., Sherwin, R., Devaskar, S., Lesche, R., Magnuson, M. A., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308617100 · Cited by 436 · see citing works
Self-citationLiver-Specific Inhibition of ChREBP Improves Hepatic Steatosis and Insulin Resistance in ob/ob Mice
Dentin, R., Benhamed, F., Hainault, I., Fauveau, V., Foufelle, F., Dyck, J. R. B., Girard, J. R., & Postic, C. (2006) · Diabetes · doi:10.2337/db06-0200 · Cited by 429 · see citing works
Mechanism for Fatty Acid “Sparing” Effect on Glucose-induced Transcription
Kawaguchi, T., Osatomi, K., Yamashita, H., Kabashima, T., & Uyeda, K. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m107895200 · Cited by 424 · see citing works
Benhamed, F., Denechaud, P.-D., Lemoine, M., Robichon, C., Moldes, M., Bertrand-Michel, J., Ratziu, V., Serfaty, L., Housset, C., Capeau, J., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci41636 · Cited by 408 · see citing works
Kabashima, T., Kawaguchi, T., Wadzinski, B. E., & Uyeda, K. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0730817100 · Cited by 401 · see citing works
Jiang, T., Wang, Z., Proctor, G., Moskowitz, S., Liebman, S. E., Rogers, T. E., Lucia, M. S., Li, J., & Levi, M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m500801200 · Cited by 387 · see citing works
ChREBP•Mlx Is the Principal Mediator of Glucose-induced Gene Expression in the Liver
Ma, L., Robinson, L. N., & Towle, H. C. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m601576200 · Cited by 373 · see citing works
Kawaguchi, T., Takenoshita, M., Kabashima, T., & Uyeda, K. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.231370798 · Cited by 373 · see citing works
A Central Role for mTOR in Lipid Homeostasis
Lamming, D. W., & Sabatini, D. M. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.08.002 · Cited by 361 · see citing works
MECHANISMS BY WHICH CARBOHYDRATES REGULATE EXPRESSION OF GENES FOR GLYCOLYTIC AND LIPOGENIC ENZYMES
Girard, J. R., Ferré, P., & Foufelle, F. (1997) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.17.1.325 · Cited by 357 · see citing works
Smith, E. M., FINN, S. G., Tee, A. R., Browne, G. J., & Proud, C. G. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m414499200 · Cited by 354 · see citing works
Walker, A. K., Yang, F., Jiang, K., Ji, J., Watts, J. L., Purushotham, A., Boss, O., Hirsch, M. L., Ribich, S. A., Smith, J. J., et al. (2010) · Genes & Development · doi:10.1101/gad.1901210 · Cited by 352 · see citing works
Familial combined hyperlipidemia is associated with upstream transcription factor 1 (USF1)
Pajukanta, P., Lilja, H. E., Sinsheimer, J. S., Cantor, R. M., Lusis, A. J., Gentile, M., Duan, X. J., Soro‐Paavonen, A., Naukkarinen, J., Saarela, J., et al. (2004) · Nature Genetics · doi:10.1038/ng1320 · Cited by 347 · see citing works
Kim, J. B., Spotts, G. D., Halvorsen, Y. C., Shih, H., Ellenberger, T., Towle, H. C., & Spiegelman, B. M. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.5.2582 · Cited by 320 · see citing works
Enzymatic Reduction of Oxysterols Impairs LXR Signaling in Cultured Cells and the Livers of Mice
Chen, W., Chen, G., Head, D. L., Mangelsdorf, D. J., & Russell, D. W. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2006.11.012 · Cited by 316 · see citing works
LXRs regulate the balance between fat storage and oxidation
Kalaany, N. Y., Gauthier, K. C., Zavacki, A. M., Mammen, P. P. A., Kitazume, T., Peterson, J. A., Horton, J. D., Garry, D. J., Bianco, A. C., & Mangelsdorf, D. J. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.03.001 · Cited by 304 · see citing works
De novo lipogenesis in human fat and liver is linked to ChREBP-β and metabolic health
Eissing, L., Scherer, T., Tödter, K., Knippschild, U., Greve, J. W. M., Buurman, W. A., Pinnschmidt, H. O., Rensen, S. S., Wolf, A. M., Bartelt, A., et al. (2013) · Nature Communications · doi:10.1038/ncomms2537 · Cited by 302 · see citing works
Bricambert, J., Miranda, J., Benhamed, F., Girard, J. R., Postic, C., & Dentin, R. (2010) · Journal of Clinical Investigation · doi:10.1172/jci41624 · Cited by 299 · see citing works
Liver-specific mRNA for Insig-2 down-regulated by insulin: Implications for fatty acid synthesis
Yabe, D., Komuro, R., Liang, G., Goldstein, J. L., & Brown, M. S. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0130116100 · Cited by 293 · see citing works
Connecting mTORC1 signaling to SREBP-1 activation
Bakan, I., & Laplante, M. (2012) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e328352dd03 · Cited by 283 · see citing works
Taniguchi, C. M., Kondo, T., Sajan, M. P., Luo, J., Bronson, R. T., Asano, T., Farese, R. V., Cantley, L. C., & Kahn, C. R. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.04.005 · Cited by 282 · see citing works
Sul, H. S., & Wang, D. (1998) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.18.1.331 · Cited by 280 · see citing works
Self-citationInsulin stimulation of SREBP-1c processing in transgenic rat hepatocytes requires p70 S6-kinase
Owen, J., Zhang, Y., Bae, S., Farooqi, M., Liang, G., Hammer, R., Goldstein, J., & Brown, M. S. (2012) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.1213343109 · Cited by 276 · see citing works
Yin, L., & Lazar, M. A. (2005) · Molecular Endocrinology · doi:10.1210/me.2005-0057 · Cited by 274 · see citing works
Insulin signalling mechanisms for triacylglycerol storage
Czech, M., Tencerová, M., Pedersen, D. J., & Aouadi, M. (2013) · Diabetologia · doi:10.1007/s00125-013-2869-1 · Cited by 272 · see citing works
López, J. M., Bennett, M. K., Sanchez, H. B., Rosenfeld, J. M., & Osborne, T. F. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.3.1049 · Cited by 262 · see citing works
Promoter Analysis of the Mouse Sterol Regulatory Element-binding Protein-1c Gene
Amemiya-Kudo, M., Shimano, H., Yoshikawa, T., Yahagi, N., Hasty, A. H., Okazaki, H., Tamura, Y., Shionoiri, F., Iizuka, Y., Ohashi, K., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m005353200 · Cited by 257 · see citing works
Hormonal Regulation of Mouse Fatty Acid Synthase Gene Transcription in Liver
Paulauskis, J. D., & Sul, H. S. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)31298-x · Cited by 255 · see citing works
Self-citationA Role of DNA-PK for the Metabolic Gene Regulation in Response to Insulin
Wong, R. H.-F., Chang, I., Hudak, C. S. S., Hyun, S., Kwan, H. Y., & Sul, H. S. (2009) · Cell · doi:10.1016/j.cell.2008.12.040 · Cited by 253 · see citing works
Self-citationThe nuclear receptor REV-ERBα is required for the daily balance of carbohydrate and lipid metabolism
Delezie, J., Dumont, S., Dardente, H., Oudart, H., Gréchez‐Cassiau, A., Klosen, P., Teboul, M., Delaunay, F., Pévet, P., & Challet, E. (2012) · The FASEB Journal · doi:10.1096/fj.12-208751 · Cited by 252 · see citing works
Sun, Z., Feng, D., Fang, B., Mullican, S. E., You, S.-H., Lim, H., Everett, L. J., Nabel, C. S., Li, Y., Selvakumaran, V., et al. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.10.022 · Cited by 247 · see citing works
Wagner, B. L., Valledor, A. F., Shao, G. Q., Daige, C. L., Bischoff, E. D., Petrowski, M. L., Jepsen, K., Baek, S. H., Heyman, R. A., Rosenfeld, M. G., et al. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.16.5780-5789.2003 · Cited by 245 · see citing works
A diurnal serum lipid integrates hepatic lipogenesis and peripheral fatty acid use
Liu, S., Brown, J. D., Stanya, K. J., Homan, E. A., Leidl, M., Inouye, K., Bhargava, P., Gangl, M. R., Dai, L., Hatano, B., et al. (2013) · Nature · doi:10.1038/nature12710 · Cited by 231 · see citing works
Stoeckman, A. K., Ma, L., & Towle, H. C. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m311301200 · Cited by 218 · see citing works
Novel insights into ChREBP regulation and function
Filhoulaud, G., Guilmeau, S., Dentin, R., Girard, J. R., & Postic, C. (2013) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2013.01.003 · Cited by 211 · see citing works
O -GlcNAcylation Increases ChREBP Protein Content and Transcriptional Activity in the Liver
Guinez, C., Filhoulaud, G., Benhamed, F., Marmier, S., Dubuquoy, C., Dentin, R., Moldes, M., Burnol, A., Yang, X., Lefebvre, T., et al. (2011) · Diabetes · doi:10.2337/db10-0452 · Cited by 211 · see citing works
Liver X Receptors as Insulin-mediating Factors in Fatty Acid and Cholesterol Biosynthesis
Tobin, K. A. R., Ulven, S. M., Schuster, G. U., Steineger, H. H., Andresen, S. M., Gustafsson, J.-Α., & Nebb, H. I. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m109771200 · Cited by 207 · see citing works
ChREBP, but not LXRs, is required for the induction of glucose-regulated genes in mouse liver
Denechaud, P., Bossard, P., Lobaccaro, J. A., Millatt, L. J., Staels, B., Girard, J. R., & Postic, C. (2008) · Journal of Clinical Investigation · doi:10.1172/jci34314 · Cited by 205 · see citing works
Haeusler, R. A., Hartil, K., Vaitheesvaran, B., Arrieta‐Cruz, I., Knight, C. M., Cook, J. R., Kammoun, H. L., Febbraio, M. A., Juárez, R. G., Kurland, I. J., et al. (2014) · Nature Communications · doi:10.1038/ncomms6190 · Cited by 192 · see citing works
Direct Role of ChREBP·Mlx in Regulating Hepatic Glucose-responsive Genes
Ma, L., Tsatsos, N. G., & Towle, H. C. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m413063200 · Cited by 190 · see citing works
Cretenet, G., Clech, M. L., & Gachon, F. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2009.11.002 · Cited by 187 · see citing works
Circadian metabolism in the light of evolution
Gerhart-Hines, Z., & Lazar, M. A. (2015) · Endocrine Reviews · doi:10.1210/er.2015-1007 · Cited by 178 · see citing works
Dentin, R., Tomás‐Cobos, L., Foufelle, F., Leopold, J. A., Girard, J. R., Postic, C., & Ferré, P. (2011) · Journal of Hepatology · doi:10.1016/j.jhep.2011.07.019 · Cited by 177 · see citing works
Glucose-Dependent Transcriptional Regulation by an Evolutionarily Conserved Glucose-Sensing Module
Li, M. V., Chang, B. H.-J., Imamura, M., Poungvarin, N., & Chan, L. (2006) · Diabetes · doi:10.2337/db05-0822 · Cited by 177 · see citing works
Matsumoto, M., Ogawa, W., Akimoto, K., Inoue, H., Miyake, K., Furukawa, K., Hayashi, Y., Iguchi, H., Matsuki, Y., Hiramatsu, R., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci18816 · Cited by 176 · see citing works
Li, S., Liu, C., Li, N., Hao, T., Han, T., HILL, D. E., Vidal, M., & Lin, J. D. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.06.013 · Cited by 167 · see citing works
Insulin signaling in fatty acid and fat synthesis: a transcriptional perspective
Wong, R. H.-F., & Sul, H. S. (2010) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2010.08.004 · Cited by 160 · see citing works
Self-citationIdentification of an insulin response element in the fatty acid synthase promoter.
Moustaïd, N., Beyer, R., & Sul, H. S. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)37507-5 · Cited by 158 · see citing works
Self-citationRoth, G., Kotzka, J., Kremer, L., Lehr, S., Lohaus, C., Meyer, H. E., Krone, W., & Müller‐Wieland, D. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m005425200 · Cited by 157 · see citing works
Latasa, M.-J., Moon, Y. S., Kim, K., & Sul, H. S. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.180306597 · Cited by 157 · see citing works
Self-citationMagaña, M., Koo, S., Towle, H. C., & Osborne, T. F. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.7.4726 · Cited by 155 · see citing works
Wang, D., & Sul, H. S. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.42.26367 · Cited by 154 · see citing works
Self-citationYuan, M., Pino, E. C., Wu, L., Kacergis, M. C., & Soukas, A. A. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.386854 · Cited by 154 · see citing works
Matsumoto, M., Ogawa, W., Akimoto, K., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200318816 · Cited by 152 · see citing works
New Facets in the Regulation of Gene Expression by ADP-Ribosylation and Poly(ADP-ribose) Polymerases
Ryu, K. W., Kim, D.-S., & Kraus, W. L. (2015) · Chemical Reviews · doi:10.1021/cr5004248 · Cited by 147 · see citing works
Beaven, S. W., Matveyenko, A. V., Wroblewski, K., Chao, L. C., Wilpitz, D. C., Hsu, T. W., Lentz, J., Drew, B. G., Hevener, A. L., & Tontonoz, P. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.04.021 · Cited by 146 · see citing works
Wang, D., & Sul, H. S. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.39.25420 · Cited by 143 · see citing works
Self-citationLiu, Z., Thompson, K. S., & Towle, H. C. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)31457-1 · Cited by 142 · see citing works
Ligand-Dependent Enhancer Activation Regulated by Topoisomerase-I Activity
Puc, J., Koźbiał, P., Li, W., Tan, Y., Liu, Z., Suter, T., Ohgi, K. A., Zhang, J., Aggarwal, A. K., & Rosenfeld, M. G. (2015) · Cell · doi:10.1016/j.cell.2014.12.023 · Cited by 139 · see citing works
Yellaturu, C. R., Deng, X., Cagen, L. M., Wilcox, H. G., Mansbach, C. M., Siddiqi, S. A., Park, E. A., Raghow, R., & Elam, M. B. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m805746200 · Cited by 138 · see citing works
Casado, M., Vallet, V. S., Kahn, A., & Vaulont, S. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.4.2009 · Cited by 137 · see citing works
Vallet, V. S., Casado, M., Henrion‐Caude, A., Bucchini, D., Raymondjean, M., Kahn, A., & Vaulont, S. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.32.20175 · Cited by 131 · see citing works
Hwahng, S. H., Ki, S. H., Bae, E. J., Kim, H. E., & Kim, S. G. (2009) · Hepatology · doi:10.1002/hep.22887 · Cited by 123 · see citing works
Self-citationSer1928 Is a Common Site for Cav1.2 Phosphorylation by Protein Kinase C Isoforms
Yang, L., Liu, G., Zakharov, S. I., Morrow, J., Rybin, V. O., Steinberg, S. F., & Marx, S. O. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m410509200 · Cited by 122 · see citing works
Yamamoto, T., Shimano, H., Inoue, N., Nakagawa, Y., Matsuzaka, T., Takahashi, A., Yahagi, N., Sone, H., Suzuki, H., Toyoshima, H., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m611911200 · Cited by 121 · see citing works
Wang, D., & Sul, H. S. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.48.28716 · Cited by 118 · see citing works
Self-citationRegulatory Role of Glycogen Synthase Kinase 3 for Transcriptional Activity of ADD1/SREBP1c
Kim, K. H., Song, M. J., Yoo, E. J., Choe, S. S., Park, S. D., & Kim, J. B. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m405522200 · Cited by 117 · see citing works
Arden, C., Tudhope, S. J., Petrie, J. L., Al‐Oanzi, Z. H., Cullen, K. S., Lange, A. J., Towle, H. C., & Agius, L. (2012) · Biochemical Journal · doi:10.1042/bj20111280 · Cited by 116 · see citing works
Liver Clock Protein BMAL1 Promotes de Novo Lipogenesis through Insulin-mTORC2-AKT Signaling
Zhang, D., Tong, X., Arthurs, B., Guha, A., Rui, L., Kamath, A., Inoki, K., & Yin, L. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.567628 · Cited by 115 · see citing works
Functional Characterization of the L-Type Pyruvate Kinase Gene Glucose Response Complex
Guerra, M. J. D., Bergot, M.-O., Martinez, A., Cuif, M., Kahn, A., & Raymondjean, M. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.12.7725 · Cited by 113 · see citing works
Transcriptional Coregulators: Fine-Tuning Metabolism
Mouchiroud, L., Eichner, L. J., Shaw, R. J., & Auwerx, J. H. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.03.027 · Cited by 111 · see citing works
Latasa, M.-J., Griffin, M. J., Moon, Y. S., Kang, C., & Sul, H. S. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.16.5896-5907.2003 · Cited by 109 · see citing works
Self-citationRegulation of Nuclear Import/Export of Carbohydrate Response Element-binding Protein (ChREBP)
Sakiyama, H., Wynn, R., Lee, W.-R., Fukasawa, M., Mizuguchi, H., Gardner, K. H., Repa, J. J., & Uyeda, K. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m804308200 · Cited by 106 · see citing works
Glucose-dependent Liver Gene Expression in Upstream Stimulatory Factor 2 −/− Mice
Vallet, V. S., Henrion‐Caude, A., Bucchini, D., Casado, M., Raymondjean, M., Kahn, A., & Vaulont, S. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.35.21944 · Cited by 105 · see citing works
Nuclear Receptor Liver X Receptor Is O-GlcNAc-modified in Response to Glucose
Anthonisen, E. H., Berven, L. L., Holm, S., Nygård, M., Nebb, H. I., & Grønning-Wang, L. M. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.082685 · Cited by 102 · see citing works
Lee, S., Lee, J., Lee, S.-K., & Lee, J. W. (2008) · Molecular Endocrinology · doi:10.1210/me.2008-0012 · Cited by 99 · see citing works
Shin, D. H., Paulauskis, J. D., Moustaïd, N., & Sul, H. S. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)54359-3 · Cited by 97 · see citing works
Self-citationPathway-selective Insulin Resistance and Metabolic Disease: The Importance of Nutrient Flux
Otero, Y. F., Stafford, J. M., & McGuinness, O. P. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.r114.576355 · Cited by 94 · see citing works
Kang, H. S., Okamoto, K., Takeda, Y., Beak, J. Y., Gerrish, K., Bortner, C. D., DeGraff, L. M., Wada, T., Xie, W., & Jetten, A. M. (2011) · Physiological Genomics · doi:10.1152/physiolgenomics.00206.2010 · Cited by 93 · see citing works
Sterol regulatory element-binding protein 1 is negatively modulated by PKA phosphorylation
Lu, M. M., & Shyy, J. Y.-J. (2005) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00374.2005 · Cited by 89 · see citing works
Athanikar, J. N., Sanchez, H. B., & Osborne, T. F. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.9.5193 · Cited by 88 · see citing works
Wang, Y., Wong, R. H.-F., Tang, T., Hudak, C. S. S., Yang, D., Duncan, R. E., & Sul, H. S. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.10.028 · Cited by 80 · see citing works
Self-citationHormonal and Nutritional Control of the Fatty Acid Synthase Promoter in Transgenic Mice
Soncini, M., Yet, S., Moon, Y. K., Chun, J.-Y., & Sul, H. S. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.51.30339 · Cited by 79 · see citing works
Self-citationGriffin, M. J., Wong, R. H.-F., Pandya, N., & Sul, H. S. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m610566200 · Cited by 69 · see citing works
Self-citationBindesbøll, C., Fan, Q., Nørgaard, R. C., MacPherson, L., Ruan, H., Wu, J., Pedersen, T. Å., Steffensen, K. R., Yang, X., Matthews, J. B., et al. (2015) · Journal of Lipid Research · doi:10.1194/jlr.m049130 · Cited by 67 · see citing works
Kemper, J. K., Choi, S.-E., & Kim, D.-H. (2013) · Vitamins and hormones · doi:10.1016/b978-0-12-407766-9.00016-x · Cited by 64 · see citing works
PIASy-Mediated Sumoylation of SREBP1c Regulates Hepatic Lipid Metabolism upon Fasting Signaling
Lee, G. Y., Jang, H., Lee, J. H., Huh, J. Y., Choi, S., Chung, J., & Kim, J. B. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.01166-13 · Cited by 64 · see citing works
Bartok, O., Teesalu, M., Ashwal-Fluss, R., Pandey, V., Hanan, M., Rovenko, B. M., Poukkula, M., Havula, E., Moussaieff, A., Vodala, S., et al. (2015) · The EMBO Journal · doi:10.15252/embj.201591385 · Cited by 60 · see citing works
Chanda, D., Li, T., Song, K. H., Kim, Y., Sim, J., Lee, C. H., Chiang, J. Y. L., & Choi, H. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.022244 · Cited by 59 · see citing works
Deng, X., Yellaturu, C. R., Cagen, L. M., Wilcox, H. G., Park, E. A., Raghow, R., & Elam, M. B. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m702228200 · Cited by 58 · see citing works
The role of O-linked GlcNAc modification on the glucose response of ChREBP
Sakiyama, H., Fujiwara, N., Noguchi, T., Eguchi, H., Yoshihara, D., Uyeda, K., & Suzuki, K. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.10.113 · Cited by 56 · see citing works
Characterization of the Murine Mitochondrial Glycerol-3-phosphate Acyltransferase Promoter
Jerkins, A. A., Liu, W. R., Lee, S.-J., & Sul, H. S. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.3.1416 · Cited by 52 · see citing works
Self-citationER Stress and Lipogenesis: A Slippery Slope toward Hepatic Steatosis
Basseri, S., & Austin, R. C. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.11.013 · Cited by 52 · see citing works
Kotzka, J., Knebel, B., Haas, J., Kremer, L., Jacob, S., Hartwig, S., Nitzgen, U., & Müller‐Wieland, D. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032609 · Cited by 51 · see citing works
Li, M. V., Chen, W., Poungvarin, N., Imamura, M., & Chan, L. (2008) · Molecular Endocrinology · doi:10.1210/me.2007-0560 · Cited by 47 · see citing works
Moon, Y. S., Latasa, M.-J., Kim, K., Wang, D., & Sul, H. S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.14.10121 · Cited by 39 · see citing works
Self-citationRegulation of Lipogenic Gene Expression by Lysine-specific Histone Demethylase-1 (LSD1)
Abdulla, A., Zhang, Y., Hsu, F.-N., Xiaoli, A. M., Zhao, X., Yang, E. S. T., Ji, J., & Yang, F. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.573659 · Cited by 39 · see citing works
Ge, Q., Huang, N. N., Wynn, R., Li, Y., Du, X., Miller, B., Zhang, H., & Uyeda, K. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.418855 · Cited by 38 · see citing works
Feldmann, R., Fischer, C., Kodelja, V., Behrens, S., Haas, S. A., Vingron, M., Timmermann, B., Geikowski, A., & Sauer, S. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt034 · Cited by 37 · see citing works
Gene Expression Needs a Break to Unwind Before Carrying On
Haince, J.-F., Rouleau, M., & Poirier, G. G. (2006) · Science · doi:10.1126/science.1129808 · Cited by 30 · see citing works
Functional Characterization of the L-Type Pyruvate Kinase Gene Glucose Response Complex
Guerra, M.-J. M. D., Bergot, M.-O., Martinez, A., et al. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.12.7725-7733.1993 · Cited by 28 · see citing works
Zhang, C., Shin, D.-J., & Osborne, T. F. (2005) · Biochemical Journal · doi:10.1042/bj20041514 · Cited by 27 · see citing works
DNA-PK: Relaying the insulin signal to USF in lipogenesis
Wong, R. H. F., & Sul, H. S. (2009) · Cell Cycle · doi:10.4161/cc.8.13.8941 · Cited by 20 · see citing works
Self-citationWnt asymmetry and the terminal division of neuronal progenitors
Bertrand, V., & Hobert, O. (2009) · Cell Cycle · doi:10.4161/cc.8.13.9024 · Cited by 12 · see citing works
A METHOD OF SEPARATING THE ANTERIOR PITUITARY-LIKE HORMONE FROM THE URINE OF PREGNANT WOMEN
Elden, C. A. (1933) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)75905-x · Cited by 5 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
AKT/PKB Signaling: Navigating the Network
Manning, B. D., & Toker, A. (2017) · Cell · doi:10.1016/j.cell.2017.04.001 · Cited by 3,772 · see citing works
SREBP-regulated lipid metabolism: convergent physiology - divergent pathophysiology
Shimano, H., & Sato, R. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2017.91 · Cited by 1,174 · see citing works
Liver fibrosis: Pathophysiology, pathogenetic targets and clinical issues
Parola, M., & Pinzani, M. (2018) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2018.09.002 · Cited by 1,183 · see citing works
Ginsberg, H. N., Packard, C. J., Chapman, M. J., Borén, J., Aguilar-Salinas, C. A., Averna, M., Ference, B. A., Gaudet, D., Hegele, R. A., Kersten, S., et al. (2021) · European Heart Journal · doi:10.1093/eurheartj/ehab551 · Cited by 979 · see citing works
Lipid droplets and liver disease: from basic biology to clinical implications
Gluchowski, N. L., Becuwe, M., Walther, T. C., & Farese, R. V. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.32 · Cited by 675 · see citing works
Direct effects of thyroid hormones on hepatic lipid metabolism
Sinha, R. A., Singh, B. K., & Yen, P. M. (2018) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2018.10 · Cited by 665 · see citing works
Metabolic-associated fatty liver disease and lipoprotein metabolism
Heeren, J., & Scheja, L. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2021.101238 · Cited by 666 · see citing works
Fleishman, J. S., & Kumar, S. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01811-6 · Cited by 577 · see citing works
Pathophysiology of Diabetic Dyslipidemia
Hirano, T. (2018) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.rv17023 · Cited by 552 · see citing works
Arroyave-Ospina, J. C., Wu, Z., Geng, Y., & Moshage, H. J. (2021) · Antioxidants · doi:10.3390/antiox10020174 · Cited by 531 · see citing works
Mardinoğlu, A., Wu, H., Björnson, E., Zhang, C., Hakkarainen, A., Räsänen, S., Lee, S., Mancina, R. M., Bergentall, M., Pietiläinen, K. H., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.01.005 · Cited by 455 · see citing works
Insulin signaling in health and disease
Saltiel, A. R. (2021) · Journal of Clinical Investigation · doi:10.1172/jci142241 · Cited by 446 · see citing works
NAFLD: Mechanisms, Treatments, and Biomarkers
Nassir, F. (2022) · Biomolecules · doi:10.3390/biom12060824 · Cited by 422 · see citing works
AMPK-Mediated Regulation of Lipid Metabolism by Phosphorylation
Wang, Q., Liu, S., Zhai, A., Zhang, B., & Tian, G. (2018) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b17-00724 · Cited by 315 · see citing works
Lipid alterations in chronic liver disease and liver cancer
Paul, B., Lewińska, M., & Andersen, J. B. (2022) · JHEP Reports · doi:10.1016/j.jhepr.2022.100479 · Cited by 311 · see citing works
Berberine attenuates nonalcoholic hepatic steatosis through the AMPK-SREBP-1c-SCD1 pathway
Zhu, X., Bian, H., Wang, L., Sun, X., Xu, X., Yan, H., Xia, M., Chang, X., Lü, Y., Li, Y., et al. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.06.019 · Cited by 274 · see citing works
Sinha, R. A., Bruinstroop, E., Singh, B. K., & Yen, P. M. (2019) · Thyroid · doi:10.1089/thy.2018.0664 · Cited by 272 · see citing works
Xue, H., Chen, X., Yu, C., Deng, Y., Zhang, Y., Shen, C., Chen, X., Chen, K., Yang, Y., & Ling, W. (2022) · Circulation Research · doi:10.1161/circresaha.122.321253 · Cited by 274 · see citing works
Insights into Stearoyl-CoA Desaturase-1 Regulation of Systemic Metabolism
Aljohani, A., Syed, D. N., & Ntambi, J. M. (2017) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2017.10.003 · Cited by 271 · see citing works
Physiological and pathological roles of lipogenesis
Jeon, Y. G., Kim, Y. Y., Lee, G., & Kim, J. B. (2023) · Nature Metabolism · doi:10.1038/s42255-023-00786-y · Cited by 248 · see citing works
Hahn, O., Grönke, S., Stubbs, T. M., Ficz, G., Hendrich, O., Krueger, F., Andrews, S., Zhang, Q., Wakelam, M. J. O., Beyer, A., et al. (2017) · Genome biology · doi:10.1186/s13059-017-1187-1 · Cited by 236 · see citing works
Linden, A. G., Li, S., Choi, H. Y., Fang, F., Fukasawa, M., Uyeda, K., Hammer, R. E., Horton, J. D., Engelking, L. J., & Liang, G. (2018) · Journal of Lipid Research · doi:10.1194/jlr.m081836 · Cited by 232 · see citing works
Sharma, R. S., Harrison, D. J., Kisielewski, D., Cassidy, D. M., McNeilly, A. D., Gallagher, J. R., Walsh, S. V., Honda, T., McCrimmon, R. J., Dinkova‐Kostova, A. T., et al. (2017) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2017.11.016 · Cited by 214 · see citing works
Endoplasmic reticulum proteostasis in hepatic steatosis
Baiceanu, A., Mesdom, P., Lagouge, M., & Foufelle, F. (2016) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.124 · Cited by 212 · see citing works
Qu, X., & Donnelly, R. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21218191 · Cited by 210 · see citing works
Sánchez-Gurmaches, J., Tang, Y., Jespersen, N. Z., Wallace, M., Calejman, C. M., Gujja, S., Li, H., Edwards, Y. J. K., Wolfrum, C., Metallo, C. M., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.10.008 · Cited by 208 · see citing works
The pathogenesis and diagnosis of sepsis post burn injury
Zhang, P., Zou, B., Liou, Y., & Huang, C. (2020) · Burns & Trauma · doi:10.1093/burnst/tkaa047 · Cited by 195 · see citing works
Thyroid hormone signaling and the liver
Ritter, M. J., Amano, I., Hollenberg, A. N., et al. (2020) · Hepatology · doi:10.1002/hep.31296 · Cited by 188 · see citing works
Homeostasis of Glucose and Lipid in Non-Alcoholic Fatty Liver Disease
Chao, H., Chao, S.-W., Lin, H., Ku, H., & Cheng, C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20020298 · Cited by 183 · see citing works
Shiba, K., Tsuchiya, K., Komiya, C., Miyachi, Y., Mori, K., Shimazu, N., Yamaguchi, S., Ogasawara, N., Katoh, M., Itoh, M., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-19658-7 · Cited by 176 · see citing works
Hepatic lipid homeostasis by peroxisome proliferator-activated receptor gamma 2
Lee, Y., Park, J. E., Lee, M., & Hardwick, J. P. (2018) · Liver Research · doi:10.1016/j.livres.2018.12.001 · Cited by 175 · see citing works
mTORC1 signaling in hepatic lipid metabolism
Han, J., & Wang, Y. (2017) · Protein & Cell · doi:10.1007/s13238-017-0409-3 · Cited by 168 · see citing works
Self-citationSGLT-2 Inhibitors in NAFLD: Expanding Their Role beyond Diabetes and Cardioprotection
Ανδρουτσάκος, Θ., Ansari, N. N., Bakasis, A., Kyrou, I., EFSTATHOPOULOS, E. P., Randeva, H. S., & Kassi, E. N. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23063107 · Cited by 172 · see citing works
Palmitic acid is an intracellular signaling molecule involved in disease development
Fatima, S., Hu, X., Gong, R., Huang, C., Chen, M., Wong, H. L. X., Bian, Z., & Kwan, H. Y. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03092-7 · Cited by 164 · see citing works
Liou, C., Lee, Y.-K., Ting, N., Chen, Y., Shen, S., Wu, S., & Huang, W. (2019) · Cells · doi:10.3390/cells8050447 · Cited by 159 · see citing works
Inhibition of nonalcoholic fatty liver disease in mice by selective inhibition of mTORC1
Gosis, B. S., Wada, S., Thorsheim, C. L., Li, K., Jung, S., Rhoades, J. H., Yang, Y., Brandimarto, J., Li, L., Uehara, K., et al. (2022) · Science · doi:10.1126/science.abf8271 · Cited by 155 · see citing works
When fats commit crimes: fatty acid metabolism, cancer stemness and therapeutic resistance
Kuo, C., & Ann, D. K. (2018) · 癌症：英文版 · doi:10.1186/s40880-018-0317-9 · Cited by 145 · see citing works
Kubota, N., Kubota, T., Kajiwara, E., Iwamura, T., Kumagai, H., Watanabe, T., Inoue, M., Takamoto, I., Sasako, T., Kumagai, K., et al. (2016) · Nature Communications · doi:10.1038/ncomms12977 · Cited by 143 · see citing works
Tuzcu, Z., Orhan, C., Şahin, N., Juturu, V., & Şahin, K. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/1583098 · Cited by 141 · see citing works
Molecular Regulation of Lipogenesis, Adipogenesis and Fat Deposition in Chicken
Nematbakhsh, S., Chong, P. P., Selamat, J., Nordin, N., Idris, L. H., & Razis, A. F. A. (2021) · Genes · doi:10.3390/genes12030414 · Cited by 139 · see citing works
The biochemical alterations underlying post-burn hypermetabolism
Auger, C., Samadi, O., & Jeschke, M. G. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.02.019 · Cited by 138 · see citing works
Long Noncoding RNA lncSHGL Recruits hnRNPA1 to Suppress Hepatic Gluconeogenesis and Lipogenesis
Wang, J., Yang, W., Chen, Z., Chen, J., Meng, Y., Feng, B., Sun, L., Dou, L., Li, J., Cui, Q., et al. (2018) · Diabetes · doi:10.2337/db17-0799 · Cited by 137 · see citing works
Important Hormones Regulating Lipid Metabolism
Zhang, D., Wei, Y., Huang, Q., Chen, Y., Zeng, K., Yang, W., Chen, J., & Chen, J. (2022) · Molecules · doi:10.3390/molecules27207052 · Cited by 136 · see citing works
Lipid metabolism in pancreatic cancer: emerging roles and potential targets
Yin, X., Xu, R., Song, J., Ruze, R., Chen, Y., Wang, C., & Xu, Q. (2022) · 癌症：英文版 · doi:10.1002/cac2.12360 · Cited by 132 · see citing works
Wang, L.-F., Wang, X., Huang, C., Hu, L. H., Xiao, Y., Guan, X., Qian, Y., Deng, K., & Xin, H. (2017) · Lipids in Health and Disease · doi:10.1186/s12944-017-0464-z · Cited by 124 · see citing works
Lonardo, A., Ballestri, S., Guaraldi, G., Nascimbeni, F., Romagnoli, D., Zona, S., & Targher, G. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i44.9674 · Cited by 123 · see citing works
A nutritional memory effect counteracts the benefits of dietary restriction in old mice
Hahn, O., Drews, L. F., Nguyen, A., Tatsuta, T., Gkioni, L., Hendrich, O., Zhang, Q., Langer, T., Pletcher, S. D., Wakelam, M. J. O., et al. (2019) · Nature Metabolism · doi:10.1038/s42255-019-0121-0 · Cited by 122 · see citing works
da Silva-Santi, L. G., Antunes, M. M., Caparroz‐Assef, S. M., Carbonera, F., Masi, L. N., Curi, R., Visentainer, J. V., & Bazotte, R. B. (2016) · Nutrients · doi:10.3390/nu8110682 · Cited by 121 · see citing works
Storage lipid studies in tuberculosis reveal that foam cell biogenesis is disease-specific
Guerrini, V., Prideaux, B., Blanc, L., Bruiners, N., Arrigucci, R., Singh, S., Liang, H.-P. H., Salamon, H., Chen, P., Lakehal, K., et al. (2018) · PLoS Pathogens · doi:10.1371/journal.ppat.1007223 · Cited by 119 · see citing works
Xing, C., Zhang, J., Zhao, H., & He, B. (2022) · International Journal of Women's Health · doi:10.2147/ijwh.s344542 · Cited by 118 · see citing works
The implications of signaling lipids in cancer metastasis
Luo, X., Zhao, X., Cheng, C., Li, N., Liu, Y., & Cao, Y. (2018) · Experimental & Molecular Medicine · doi:10.1038/s12276-018-0150-x · Cited by 114 · see citing works
Farnesoid X receptor: A “homeostat” for hepatic nutrient metabolism
Massafra, V., & van Mil, S. W. C. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.10.003 · Cited by 113 · see citing works
Metabolic Changes of Hepatocytes in NAFLD
Lu, Q., Tian, X., Wu, H., Huang, J., Li, M., Mei, Z., Zhou, L., Xie, H., & Zheng, S. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.710420 · Cited by 113 · see citing works
Subclinical Hypothyroidism in Patients with Obesity and Metabolic Syndrome: A Narrative Review
Biondi, B. (2023) · Nutrients · doi:10.3390/nu16010087 · Cited by 122 · see citing works
Selective insulin resistance with differential expressions of IRS-1 and IRS-2 in human NAFLD livers
Honma, M., Sawada, S., Ueno, Y., Murakami, K., Yamada, T., Gao, J., Kodama, S., Izumi, T., Takahashi, K., Tsukita, S., et al. (2018) · International Journal of Obesity · doi:10.1038/s41366-018-0062-9 · Cited by 108 · see citing works
Impact of Coffee and Cacao Purine Metabolites on Neuroplasticity and Neurodegenerative Disease
Camandola, S., Plick, N., & Mattson, M. (2018) · Neurochemical Research · doi:10.1007/s11064-018-2492-0 · Cited by 89 · see citing works
Targeting Lipid Metabolism in Liver Cancer
Alannan, M., Fayyad‐Kazan, H., Trézéguet, V., & Merched, A. J. (2020) · Biochemistry · doi:10.1021/acs.biochem.0c00477 · Cited by 110 · see citing works
Peng, Y., Gao, P., Shi, L., Chen, L., Liu, J., & Long, J. (2020) · Antioxidants & Redox Signaling · doi:10.1089/ars.2019.7763 · Cited by 110 · see citing works
Bagchi, D. P., Nishii, A., Li, Z., DelProposto, J. B., Corsa, C. A. S., Mori, H., Hardij, J., Learman, B. S., Lumeng, C. N.-K., & MacDougald, O. A. (2020) · Molecular Metabolism · doi:10.1016/j.molmet.2020.101078 · Cited by 105 · see citing works
Silibinin Restores NAD+ Levels and Induces the SIRT1/AMPK Pathway in Non-Alcoholic Fatty Liver
Salomone, F., Barbagallo, I. A., Godos, J., Lembo, V., Currenti, W., Cinà, D., Avola, R., D’Orazio, N., Morisco, F., Galvano, F., et al. (2017) · Nutrients · doi:10.3390/nu9101086 · Cited by 104 · see citing works
Iracheta‐Vellve, A., Calenda, C. D., Petrášek, J., Ambade, A., Kodys, K., Adorini, L., & Szabó, G. (2018) · Hepatology Communications · doi:10.1002/hep4.1256 · Cited by 104 · see citing works
The Role and Mechanism of Oxidative Stress and Nuclear Receptors in the Development of NAFLD
Hong, T., Chen, Y., Li, X., & Lü, Y. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/6889533 · Cited by 104 · see citing works
Liou, C., Wei, C.-H., Chen, Y.-L., Cheng, C., Wang, C.-L., & Huang, W. (2018) · Cellular Physiology and Biochemistry · doi:10.1159/000493650 · Cited by 103 · see citing works
Physiological Role of Bile Acids Modified by the Gut Microbiome
Kiriyama, Y., & Nochi, H. (2021) · Microorganisms · doi:10.3390/microorganisms10010068 · Cited by 101 · see citing works
Roles of RNA Modifications in Diverse Cellular Functions
Wilkinson, E., Cui, Y., & He, Y. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.828683 · Cited by 102 · see citing works
Parra-Landazury, N. M., Córdova‐Gallardo, J., & Méndez‐Sánchez, N. (2021) · Visceral Medicine · doi:10.1159/000515545 · Cited by 100 · see citing works
Johnson, S. M., Bao, H., McMahon, C. E., Chen, Y., Burr, S. D., Anderson, A. M., Madeyski-Bengtson, K., Lindén, D., Han, X., & Liu, J. (2024) · Nature Communications · doi:10.1038/s41467-024-49224-x · Cited by 100 · see citing works
Zhao, J., Zhang, X., Gao, T. X., Wang, S., Hou, Y., Yuan, P., Yang, Y., Yang, T., Xing, J., Li, J., et al. (2020) · Cell Death and Disease · doi:10.1038/s41419-019-2221-x · Cited by 99 · see citing works
The Interplay of Lipids, Lipoproteins, and Immunity in Atherosclerosis
Pirillo, A., Bonacina, F., Norata, G. D., & Catapano, A. L. (2018) · Current Atherosclerosis Reports · doi:10.1007/s11883-018-0715-0 · Cited by 97 · see citing works
Adropin: An endocrine link between the biological clock and cholesterol homeostasis
Ghoshal, S., Stevens, J. R., Billon, C., Clemence, G., Sitaula, S., Leon, A. S., Rao, D. C., Skinner, J. S., Rankinen, T., Bouchard, C., et al. (2017) · Molecular Metabolism · doi:10.1016/j.molmet.2017.12.002 · Cited by 96 · see citing works
Gut Microbiota Is a Major Contributor to Adiposity in Pigs
Yang, H., Xiang, Y., Robinson, K., Wang, J., Zhang, G., Zhao, J., & Xiao, Y. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.03045 · Cited by 96 · see citing works
Martínez, B. A., Hoyle, R. G., Yeudall, S., Granade, M. E., Harris, T. E., Castle, J. D., Leitinger, N., & Bland, M. L. (2020) · PLoS Genetics · doi:10.1371/journal.pgen.1009192 · Cited by 95 · see citing works
Huang, P. F., Huang, F., Liu, H.-Z., Zhang, T., Yang, M., & Sun, C. (2019) · Metabolism · doi:10.1016/j.metabol.2019.01.018 · Cited by 94 · see citing works
Tan, S. M., Ziemann, M., Thallas‐Bonke, V., Snelson, M., Kumar, V., Laskowski, A., Nguyen, T.-V., Huynh, K., Clarke, M. V., Libianto, R., et al. (2019) · Diabetes · doi:10.2337/db19-0043 · Cited by 94 · see citing works
Tracing insights into de novo lipogenesis in liver and adipose tissues
Wallace, M., & Metallo, C. M. (2020) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2020.02.012 · Cited by 94 · see citing works
Smati, S., Polizzi, A., Fougerat, A., Ellero-Simatos, S., Blum, Y., Lippi, Y., Régnier, M., Laroyenne, A., Huillet, M., Arif, M., et al. (2021) · Gut · doi:10.1136/gutjnl-2020-323323 · Cited by 78 · see citing works
Lipometabolism and Glycometabolism in Liver Diseases
Ding, H., Wang, J., Ren, H., & Shi, X. (2018) · BioMed Research International · doi:10.1155/2018/1287127 · Cited by 88 · see citing works
Multifactorial Basis and Therapeutic Strategies in Metabolism-Related Diseases
Guerra, J. V. D. S., Dias, M. M. G., Brilhante, A. J. V. C., Terra, M. F., García‐Arévalo, M., & Figueira, A. C. M. (2021) · Nutrients · doi:10.3390/nu13082830 · Cited by 87 · see citing works
Yang, M., Bose, S., Lim, S.-K., Seo, J., Shin, J., Lee, D., Chung, W., Song, E., Nam, Y., & Kim, H. (2020) · Microorganisms · doi:10.3390/microorganisms8091413 · Cited by 85 · see citing works
Truong, X. T., & Lee, D. H. (2025) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2025.0644 · Cited by 84 · see citing works
Iizuka, K. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2016.11.029 · Cited by 83 · see citing works
SREBF1 Activity Is Regulated by an AR/mTOR Nuclear Axis in Prostate Cancer
Audet‐Walsh, É., Vernier, M., Yee, T., Laflamme, C., Li, S., Chen, Y., & Giguère, V. (2018) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-17-0410 · Cited by 81 · see citing works
Kim, Y.-C., Seok, S., Zhang, Y., Ma, J., Kong, B., Guo, G. L., Kemper, B., & Kemper, J. (2020) · Nature Communications · doi:10.1038/s41467-020-19803-9 · Cited by 73 · see citing works
Calcaterra, V., Regalbuto, C., Porri, D., Pelizzo, G., Mazzon, E., Vinci, F., Zuccotti, G., Fabiano, V., & Cena, H. (2020) · Biomolecules · doi:10.3390/biom10091324 · Cited by 81 · see citing works
Berrios, C. J., Padi, M., Keibler, M. A., Park, D. E., Vadim, M., Cheng, J., Lee, S. M., Stephanopoulos, G. N., Quackenbush, J. F., & DeCaprio, J. A. (2016) · PLoS Pathogens · doi:10.1371/journal.ppat.1006020 · Cited by 79 · see citing works
Chang, Y.-H., Chen, Y.-L., Huang, W., & Liou, C. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.11.022 · Cited by 79 · see citing works
Lipid droplet dynamics regulate adult muscle stem cell fate
Yue, F., Oprescu, S. N., Qiu, J., Gu, L., Zhang, L., Chen, J., Narayanan, N., Deng, M., & Kuang, S. (2022) · Cell Reports · doi:10.1016/j.celrep.2021.110267 · Cited by 78 · see citing works
Ballestri, S., Nascimbeni, F., Romagnoli, D., Baldelli, E., & Lonardo, A. (2016) · Advances in Therapy · doi:10.1007/s12325-016-0306-9 · Cited by 77 · see citing works
LAMP3 regulates hepatic lipid metabolism through activating PI3K/Akt pathway
Liao, X., Song, L., Zhang, L., Wang, H., Tong, Q., Xu, J., Yang, G., Yang, S., & Zheng, H. (2017) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.10.010 · Cited by 77 · see citing works
mTOR: A Potential New Target in Nonalcoholic Fatty Liver Disease
Feng, J., Qiu, S., Zhou, S., Tan, Y., Bai, Y., Cao, H., Guo, J., & Su, Z. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23169196 · Cited by 74 · see citing works
Transcriptional control of physiological and pathological processes by the nuclear receptor PPARβ/δ
Tan, N. S., Vázquez‐Carrera, M., Montagner, A., Sng, M. K., Guillou, H., & Wahli, W. (2016) · Progress in Lipid Research · doi:10.1016/j.plipres.2016.09.001 · Cited by 74 · see citing works
Liou, C., Dai, Y., Wang, C., Fang, L., & Huang, W. (2019) · The FASEB Journal · doi:10.1096/fj.201900413rrr · Cited by 74 · see citing works
Histone demethylase JMJD1C is phosphorylated by mTOR to activate de novo lipogenesis
Viscarra, J. A., Wang, Y., Nguyen, H. P., Choi, Y. G., & Sul, H. S. (2020) · Nature Communications · doi:10.1038/s41467-020-14617-1 · Cited by 73 · see citing works
Self-citationKrüppel-Like Factors in Metabolic Homeostasis and Cardiometabolic Disease
Oishi, Y., & Manabe, I. (2018) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2018.00069 · Cited by 73 · see citing works
Cai, H., Jiang, Z., Yang, X., Lin, J., Cai, Q., & Li, X. (2019) · Endocrine Journal · doi:10.1507/endocrj.ej19-0271 · Cited by 71 · see citing works
HFD-induced hepatic lipid accumulation and inflammation are decreased in Factor D deficient mouse
Tsuru, H., Osaka, M., Hiraoka, Y., & Yoshida, M. (2020) · Scientific Reports · doi:10.1038/s41598-020-74617-5 · Cited by 71 · see citing works
Sensitivity to Thyroid Hormone Indices Are Closely Associated With NAFLD
Lai, S., Li, J., Wang, Z., Wang, W., & Guan, H. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.766419 · Cited by 71 · see citing works
Zhou, S., You, H., Qiu, S., Yu, D., Bai, Y., He, J., Cao, H., Che, Q., Guo, J., & Su, Z. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113577 · Cited by 70 · see citing works
An HDAC3-PROX1 corepressor module acts on HNF4α to control hepatic triglycerides
Armour, S. M., Remsberg, J. R., Damle, M., Sidoli, S., Ho, W. Y., Li, Z., Garcia, B. A., & Lazar, M. A. (2017) · Nature Communications · doi:10.1038/s41467-017-00772-5 · Cited by 69 · see citing works
SPIN1 triggers abnormal lipid metabolism and enhances tumor growth in liver cancer
Zhao, M., Bu, Y., Feng, J., Zhang, H., Chen, Y., Yang, G., Liu, Z., Yuan, H., Yuan, Y., Liu, L., et al. (2019) · Cancer Letters · doi:10.1016/j.canlet.2019.11.032 · Cited by 68 · see citing works
- Authors
- Wang, Y., Viscarra, J., Kim, S.-J., & Sul, H. S.
- Affiliations
- University of California, Berkeley (US)
- Corresponding author
- Sul, Hei Sook
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2015-10-22
- Volume
- 16
- Issue
- 11
- Pages
- 678-689
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- PMC
- PMC4884795
- OpenAlex
- W2174107467
- Cited by
- 646
- References
- 135
- Citations by year
- 2026: 24 · 2025: 52 · 2024: 60 · 2023: 71 · 2022: 85 · 2021: 74 · 2020: 84 · 2019: 62 · 2018: 67 · 2017: 49 · 2016: 17 · 2015: 1
- FWCI
- 4.23
- Type
- journal article
- Language
- en
- Update notices
- erratum (2015-12-16)
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature Reviews Molecular Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (DK105671, F32DK105671, R01DK081098, DK081098)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Keywords
- hepatic lipogenesis, transcriptional regulation, upstream stimulatory factor, SREBP-1c, liver X receptor, ChREBP, DNA-dependent protein kinase, atypical protein kinase C, Akt/mTOR signaling, VLDL production, hepatic steatosis, insulin resistance, obesity
- MeSH terms
- Liver X Receptors, Animals, Fatty Acids, Gene Expression Regulation, Lipoproteins, VLDL, Liver, Nuclear Proteins, Protein Kinase C, Protein Processing, Post-Translational, Transcription Factors, Transcription, Genetic, Signal Transduction, Lipogenesis, Proto-Oncogene Proteins c-akt, Mice, Upstream Stimulatory Factors, DNA-Activated Protein Kinase, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, Sterol Regulatory Element Binding Protein 1, Orphan Nuclear Receptors, TOR Serine-Threonine Kinases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
