The DOI matches its Crossref record; 110 of the 110 references it cites were found in a registry or an index.
V ITAMIN A, I NFECTION,AND I MMUNE F UNCTION*
Abstract
▪ Abstract In populations where vitamin A availability from food is low, infectious diseases can precipitate vitamin A deficiency by decreasing intake, decreasing absorption, and increasing excretion. Infectious diseases that induce the acute-phase response also impair the assessment of vitamin A status by transiently depressing serum retinol concentrations. Vitamin A deficiency impairs innate immunity by impeding normal regeneration of mucosal barriers damaged by infection, and by diminishing the function of neutrophils, macrophages, and natural killer cells. Vitamin A is also required for adaptive immunity and plays a role in the development of T both-helper (Th) cells and B-cells. In particular, vitamin A deficiency diminishes antibody-mediated responses directed by Th2 cells, although some aspects of Th1-mediated immunity are also diminished. These changes in mucosal epithelial regeneration and immune function presumably account for the increased mortality seen in vitamin A–deficient infants, young children, and pregnant women in many areas of the world today.
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Cites
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IMPACT OF VITAMIN A SUPPLEMENTATION ON CHILDHOOD MORTALITY
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Cited by
A Membrane Receptor for Retinol Binding Protein Mediates Cellular Uptake of Vitamin A
Kawaguchi, R., Yu, J., Honda, J., Hu, J., Whitelegge, J., Ping, P., Wiita, P., Bok, D., & Sun, H. (2007) · Science · doi:10.1126/science.1136244 · Cited by 836
Dendritic cells in intestinal immune regulation
Coombes, J. L., & Powrie, F. (2008) · Nature Reviews Immunology · doi:10.1038/nri2335 · Cited by 788
Contribution of Selected Vitamins and Trace Elements to Immune Function
Wintergerst, E. S., Maggini, S., & Hornig, D. H. (2007) · Annals of Nutrition and Metabolism · doi:10.1159/000107673 · Cited by 692
Role of Vitamin A in the Immune System
Huang, Z., Liu, Y., Qi, G., Brand, D., & Zheng, S. (2018) · Journal of Clinical Medicine · doi:10.3390/jcm7090258 · Cited by 597
Stevens, G. A., Bennett, J. E., Hennocq, Q., Lu, Y., De-Regil, L. M., Rogers, L., Danaei, G., Li, G., White, R. A., Flaxman, S. R., et al. (2015) · The Lancet Global Health · doi:10.1016/s2214-109x(15)00039-x · Cited by 572
Metadata
- Authors
- Stephensen, C. B.
- Venue
- Annual Review of Nutrition
- Publisher
- Annual Reviews
- Published
- 2001-07
- Volume
- 21
- Issue
- 1
- Pages
- 167-192
- ISSN
- 0199-9885 (ISSN-L)
- 1545-4312
- OpenAlex
- W2158231545
- Cited by
- 773
- References
- 110
- FWCI
- 1.06
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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