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The Genetics of Anorexia Nervosa
Abstract
Anorexia nervosa is a perplexing illness marked by low body weight and persistent fear of weight gain. Anorexia nervosa has the highest mortality rate of any psychiatric disease. Historically, anorexia nervosa was viewed as a disorder primarily influenced by sociocultural factors; however, over the past decade, this perception has been challenged. Family studies have consistently demonstrated that anorexia nervosa runs in families. Twin studies have underscored the contribution of additive genetic factors to the observed familial aggregation. With these bodies of literature as a starting point, we evaluate critically the current state of research on molecular genetic studies of anorexia nervosa and provide guidance for future research.
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“Decreased activity in the amygdala, which is the core structure involved in emotional processing,8 has consistently been shown in mindfulness studies.4”
From Neural correlates of a mindfulness-based intervention in anorexia nervosa (2023) · cites this paper as [8]
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Metadata
- Authors
- Bulik, C. M., Slof-Op't Landt, M. C. T., van Furth, E. F., & Sullivan, P. F.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Department of Psychiatry, 2Department of Nutrition, and 3Department of Genetics, University of North Carolina at Chapel Hill, North Carolina 27599; 4Centrum Eetstoornissen Ursula, National Center for Eating Disorders, Leidschendam, The Netherlands; 5Molecular Epidemiology Section (Department of Medical Statistics) and 6Department of Psychiatry, Leiden University Medical Center, The Netherlands; 7Department of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands;
- Venue
- Annual Review of Nutrition
- Publisher
- Annual Reviews
- Published
- 2007-08-01
- Volume
- 27
- Issue
- 1
- Pages
- 263-275
- ISSN
- 0199-9885 (ISSN-L)
- 1545-4312
- OpenAlex
- W2140334058
- Cited by
- 150
- References
- 65
- Citations by year
- 2025: 2 · 2024: 3 · 2023: 3 · 2022: 1 · 2021: 7 · 2020: 3 · 2019: 3 · 2018: 5 · 2017: 4 · 2016: 10 · 2015: 10 · 2014: 13 · 2013: 18 · 2012: 9
- FWCI
- 2.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- anorexia nervosa, genetics, heritability, twin studies, familial aggregation, additive genetic effects, sociocultural factors, eating disorders
- MeSH terms
- Anorexia Nervosa, Body Weight, Depressive Disorder, Diseases in Twins, Family, Humans, Genetic Linkage, Obesity, Risk Factors, Twin Studies as Topic, Genetic Predisposition to Disease
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