The DOI matches its Crossref record; 157 of the 157 references it cites were found in a registry or an index.
The Inflammatory Response to Cell Death
Open accessAbstract
When cells die in vivo, they trigger an inflammatory response. The ensuing hyperemia, leak of plasma proteins, and recruitment of leukocytes serve a number of useful functions in host defense and tissue repair. However, this response can also cause tissue damage and contribute to the pathogenesis of a number of diseases. Given the key role of inflammation in these processes, it is important to understand the underlying mechanisms that drive this response. Injured cells release danger signals that alert the host to cell death. Some of these molecules are recognized by cellular receptors that stimulate the generation of proinflammatory mediators. Other molecules released by dead cells stimulate the generation of mediators from extracellular sources. The resulting mediators then orchestrate the inflammatory response, eliciting its various vascular and cellular components. Dead cells also release danger signals that activate dendritic cells and promote the generation of immune responses to antigens. Here we review what is presently known about the sterile inflammatory response and its underlying mechanisms.
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Cites
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Cited by
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Metadata
- Authors
- Rock, K. L., & Kono, H.
- Venue
- Annual Review of Pathology: Mechanisms of Disease
- Publisher
- Annual Reviews
- Published
- 2008-02-01
- Volume
- 3
- Issue
- 1
- Pages
- 99-126
- ISSN
- 1553-4006 (ISSN-L)
- 1553-4014
- OpenAlex
- W2152099551
- Cited by
- 912
- References
- 157
- FWCI
- 1.69
- Type
- journal article
- Language
- en
- Open access
- green
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