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Cited by 775

The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.

A Glimpse of Various Pathogenetic Mechanisms of Diabetic Nephropathy

Open access
Kanwar, Yashpal S., Sun, Lin, Xie, Ping, Liu, Fu-you, Chen, Sheldon·2011·Annual Review of Pathology: Mechanisms of Disease
DOI 10.1146/annurev.pathol.4.110807.092150
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Abstract

Diabetic nephropathy is a well-known complication of diabetes and is a leading cause of chronic renal failure in the Western world. It is characterized by the accumulation of extracellular matrix in the glomerular and tubulointerstitial compartments and by the thickening and hyalinization of intrarenal vasculature. The various cellular events and signaling pathways activated during diabetic nephropathy may be similar in different cell types. Such cellular events include excessive channeling of glucose intermediaries into various metabolic pathways with generation of advanced glycation products, activation of protein kinase C, increased expression of transforming growth factor β and GTP-binding proteins, and generation of reactive oxygen species. In addition to these metabolic and biochemical derangements, changes in the intraglomerular hemodynamics, modulated in part by local activation of the renin-angiotensin system, compound the hyperglycemia-induced injury. Events involving various intersecting pathways occur in most cell types of the kidney.

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Metadata

Authors
Kanwar, Y. S., Sun, L., Xie, P., Liu, F.-Y., & Chen, S.
Venue
Annual Review of Pathology: Mechanisms of Disease
Publisher
Annual Reviews
Published
2011-02-28
Volume
6
Issue
1
Pages
395-423
ISSN
  • 1553-4006 (ISSN-L)
  • 1553-4014
DOI
10.1146/annurev.pathol.4.110807.092150
OpenAlex
W2124502714
Cited by
775
References
13
FWCI
4.44
Type
journal article
Language
en
Open access
green

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Kanwar, Y. S., Sun, L., Xie, P., Liu, F.-Y., & Chen, S. (2011). A Glimpse of Various Pathogenetic Mechanisms of Diabetic Nephropathy. Annual Review of Pathology: Mechanisms of Disease. https://doi.org/10.1146/annurev.pathol.4.110807.092150

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.