The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Metabotropic Glutamate Receptors: Physiology, Pharmacology, and Disease
Open accessAbstract
The metabotropic glutamate receptors (mGluRs) are family C G-protein-coupled receptors that participate in the modulation of synaptic transmission and neuronal excitability throughout the central nervous system. The mGluRs bind glutamate within a large extracellular domain and transmit signals through the receptor protein to intracellular signaling partners. A great deal of progress has been made in determining the mechanisms by which mGluRs are activated, proteins with which they interact, and orthosteric and allosteric ligands that can modulate receptor activity. The widespread expression of mGluRs makes these receptors particularly attractive drug targets, and recent studies continue to validate the therapeutic utility of mGluR ligands in neurological and psychiatric disorders such as Alzheimer's disease, Parkinson's disease, anxiety, depression, and schizophrenia.
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Cites
The mGluR theory of fragile X mental retardation
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Identification of a serotonin/glutamate receptor complex implicated in psychosis
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Mood disorders: Regulation by metabotropic glutamate receptors
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Experimental and theoretical approaches to conscious processing
Dehaene, S., & Changeux, J.-P. (2011) · Neuron · doi:10.1016/j.neuron.2011.03.018 · Cited by 2,573
Verkhratsky, A., & Nedergaard, M. (2018) · Physiological Reviews · doi:10.1152/physrev.00042.2016 · Cited by 1,678
Hippocampal GABAergic Inhibitory Interneurons
Pelkey, K. A., Chittajallu, R., Craig, M. T., Tricoire, L., Wester, J. C., & McBain, C. J. (2017) · Physiological Reviews · doi:10.1152/physrev.00007.2017 · Cited by 889
Scofield, M. D., Heinsbroek, J. A., Gipson, C. D., Kupchik, Y. M., Spencer, S., Smith, A. C. W., Roberts-Wolfe, D., & Kalivas, P. W. (2016) · Pharmacological Reviews · doi:10.1124/pr.116.012484 · Cited by 598
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Metadata
- Authors
- Niswender, C. M., & Conn, P. J.
- Venue
- Annual Review of Pharmacology and Toxicology
- Publisher
- Annual Reviews
- Published
- 2010-02-01
- Volume
- 50
- Issue
- 1
- Pages
- 295-322
- ISSN
- 0362-1642 (ISSN-L)
- 1545-4304
- OpenAlex
- W2120307371
- Cited by
- 1,892
- References
- 14
- FWCI
- 5.85
- Type
- journal article
- Language
- en
- Open access
- green
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- Niswender, C. M., & Conn, P. J. (2010). Metabotropic Glutamate Receptors: Physiology, Pharmacology, and Disease. Annual Review of Pharmacology and Toxicology. https://doi.org/10.1146/annurev.pharmtox.011008.145533
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
