Reduced hippocampal long-term potentiation and context-specific deficit in associative learning in mGluR1 mutant mice.

Aiba, A

doi:10.1016/0092-8674(94)90204-6

Cited by 617Neuroscience and Neuropharmacology ResearchMemory and Neural MechanismsGenetics and Neurodevelopmental Disorders

Reduced hippocampal long-term potentiation and context-specific deficit in associative learning in mGluR1 mutant mice.

Aiba, A·1994·Cell

DOI 10.1016/0092-8674(94)90204-6

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Abstract

We generated a novel strain of mutant mouse with a deletion in the gene encoding metabotropic glutamate receptor 1 (mGluR1). Gross anatomy of the hippocampus, excitatory synaptic transmission, long-term depression, and short-term potentiation in the hippocampal CA1 region are all apparently normal in the mutant mice. In contrast, long-term potentiation (LTP) is substantially reduced, and a moderate level of impairment is observed in context-specific associative learning. We propose that mGluR1 is not "in line" in LTP production, but rather modulates the plasticity process, and hence affects context-specific associative learning.

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The only exceptional case, the mGluR1 mutant mice, is complicated by the fact that two groups have generated and analyzed these mutants independently and have obtained opposing results.
“It is important to point out that the only exceptional case, namely that of the mGluR1 mutant mice, is complicated by the fact that two groups have generated and analyzed these mutants independently and have obtained opposing results (Aiba et al., 1994; Conquet et al., 1994; Chen and Tonegawa, 1997).”
From The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory. (1996) · cites this paper as Aiba et al., 1994
The hippocampus plays a crucial role in context-dependent fear conditioning.
“Numerous studies, using lesioning (Kim and Fanselow, 1992;Phillips and LeDoux, 1992) and genetic (Aiba et al., 1994;Tsien et al., 1996) strategies, indicated that the hippocampus plays a crucial role in context-dependent fear conditioning.”
From Modulation of learning and anxiety by corticotropin-releasing factor (CRF) and stress: differential roles of CRF receptors 1 and 2 (1999) · cites this paper as Aiba et al., 1994

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction
Chomczynski, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1006/abio.1987.9999 · Cited by 65,240 · see citing works
Memory and the hippocampus: A synthesis from findings with rats, monkeys, and humans.
Squire, L. R. (1992) · Psychological Review · doi:10.1037/0033-295x.99.2.195 · Cited by 5,376 · see citing works
Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5
Morris, R. G. M., Anderson, E., Lynch, G. S., & Baudry, M. (1986) · Nature · doi:10.1038/319774a0 · Cited by 3,640 · see citing works
Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning.
Phillips, R. G., & LeDoux, J. E. (1992) · Behavioral Neuroscience · doi:10.1037/0735-7044.106.2.274 · Cited by 3,292 · see citing works
Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning.
Phillips, R. G., & LeDoux, J. E. (1992) · Behavioral Neuroscience · doi:10.1037//0735-7044.106.2.274 · Cited by 3,262 · see citing works
Molecular diversity of glutamate receptors and implications for brain function
Nakanishi, S. (1992) · Science · doi:10.1126/science.1329206 · Cited by 2,543 · see citing works
Modality-Specific Retrograde Amnesia of Fear
Kim, J. J., & Fanselow, M. S. (1992) · Science · doi:10.1126/science.1585183 · Cited by 2,483 · see citing works
Homosynaptic long-term depression in area CA1 of hippocampus and effects of N-methyl-D-aspartate receptor blockade.
Dudek, S. M., & Bear, M. F. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.10.4363 · Cited by 1,708 · see citing works
Deficient Hippocampal Long-Term Potentiation in α-Calcium-Calmodulin Kinase II Mutant Mice
Silva, A. J., Stevens, C. F., Tonegawa, S., & Wang, Y. (1992) · Science · doi:10.1126/science.1378648 · Cited by 1,472 · see citing works
Impaired Spatial Learning in α-Calcium-Calmodulin Kinase II Mutant Mice
Silva, A. J., Paylor, R. E., Wehner, J. M., & Tonegawa, S. (1992) · Science · doi:10.1126/science.1321493 · Cited by 1,351 · see citing works
Sequence and expression of a metabotropic glutamate receptor
Masu, M., Tanabe, Y., Tsuchida, K., Shigemoto, R., & Nakanishi, S. (1991) · Nature · doi:10.1038/349760a0 · Cited by 1,216 · see citing works
Impaired Long-Term Potentiation, Spatial Learning, and Hippocampal Development in fyn Mutant Mice
Grant, S. G. N., O’Dell, T. J., Karl, K. A., Stein, P. L., Soriano, P. M., & Kandel, E. R. (1992) · Science · doi:10.1126/science.1361685 · Cited by 1,154 · see citing works
Whole cell recording from neurons in slices of reptilian and mammalian cerebral cortex
Blanton, M. G., Turco, J. J. L., & Kriegstein, A. R. (1989) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(89)90131-3 · Cited by 945 · see citing works
Deficient cerebellar long-term depression and impaired motor learning in mGluR1 mutant mice
Aiba, A., Kano, M., Chen, C., Stanton, M. E., Fox, G. D., Herrup, K., Zwingman, T. A., & Tonegawa, S. (1994) · Cell · doi:10.1016/0092-8674(94)90205-4 · Cited by 930 · see citing works
Self-citation
The metabotropic glutamate receptor (mGluRlα) is concentrated at perisynaptic membrane of neuronal subpopulations as detected by immunogold reaction
Baude, A., Nusser, Z., Roberts, J. D. B., Mulvihill, E., Jeffrey Mcllhinney, R. A., & Somogyi, P. (1993) · Neuron · doi:10.1016/0896-6273(93)90086-7 · Cited by 927 · see citing works
The hippocampus—what does it do?
Eichenbaum, H., Otto, T., & Cohen, N. J. (1992) · Behavioral and Neural Biology · doi:10.1016/0163-1047(92)90724-i · Cited by 867 · see citing works
Metabotropic glutamate receptors in brain function and pathology
Schoepp, D. D., & Conn, P. J. (1993) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(93)90107-u · Cited by 793 · see citing works
Induction of LTP in the hippocampus needs synaptic activation of glutamate metabotropic receptors
Bashir, Z. I., Bortolotto, Z. A., Davies, C. H., Berretta, N., Irving, A. J., Seal, A., Henley, J. M., Jane, D. E., Watkins, J. C., & Collingridge, G. L. (1993) · Nature · doi:10.1038/363347a0 · Cited by 733 · see citing works
The ligand-binding domain in metabotropic glutamate receptors is related to bacterial periplasmic binding proteins
O’Hara, P. J., Sheppard, P. O., Thøgersen, H., Venezia, D., Haldeman, B. A., McGrane, V., Houamed, K. M., Thomsen, C., Gilbert, T., & Mulvihill, E. R. (1993) · Neuron · doi:10.1016/0896-6273(93)90269-w · Cited by 707 · see citing works
Distribution of the mRNA for a metabotropic glutamate receptor (mGluR1) in the central nervous system: An in situ hybridization study in adult and developing rat
Shigemoto, R., Nakanishi, S., & Mizuno, N. (1992) · The Journal of Comparative Neurology · doi:10.1002/cne.903220110 · Cited by 644 · see citing works
Cellular localization of a metabotropic glutamate receptor in rat brain
Martin, L. J., Blackstone, C. D., Huganir, R. L., & Price, D. L. (1992) · Neuron · doi:10.1016/0896-6273(92)90165-a · Cited by 552 · see citing works
PKCγ mutant mice exhibit mild deficits in spatial and contextual learning
Abeliovich, A., Paylor, R. E., Chen, C., Kim, J. J., Wehner, J. M., & Tonegawa, S. (1993) · Cell · doi:10.1016/0092-8674(93)90614-v · Cited by 535 · see citing works
Modified hippocampal long-term potentiation in PKCγ-mutant mice
Abeliovich, A., Chen, C., Goda, Y., Silva, A. J., Stevens, C. F., & Tonegawa, S. (1993) · Cell · doi:10.1016/0092-8674(93)90613-u · Cited by 524 · see citing works
Postsynaptic induction and presynaptic expression of hippocampal long-term depression.
Bolshakov, V., & Siegelbaum, S. (1994) · Science · doi:10.1126/science.7909958 · Cited by 489 · see citing works
Agonists at metabotropic glutamate receptors presynaptically inhibit EPSCs in neonatal rat hippocampus.
Baskys, A., & Malenka, R. C. (1991) · The Journal of Physiology · doi:10.1113/jphysiol.1991.sp018901 · Cited by 429 · see citing works
A molecular switch activated by metabotropic glutamate receptors regulates induction of long-term potentiation
Bortolotto, Z. A., Bashir, Z. I., Davies, C. H., & Collingridge, G. L. (1994) · Nature · doi:10.1038/368740a0 · Cited by 426 · see citing works
Locally Distributed Synaptic Potentiation in the Hippocampus
Schuman, E. M., & Madison, D. V. (1994) · Science · doi:10.1126/science.8290963 · Cited by 352 · see citing works
Role of a metabotropic glutamate receptor in synaptic modulation in the accessory olfactory bulb
Hayashi, Y., Momiyama, A., Takahashi, T., Ohishi, H., Ogawa-Meguro, R., Shigemoto, R., Mizuno, N., & Nakanishi, S. (1993) · Nature · doi:10.1038/366687a0 · Cited by 350 · see citing works
Analysis of agonist and antagonist activities of phenylglycine derivatives for different cloned metabotropic glutamate receptor subtypes
Hayashi, Y., Sekiyama, N., Nakanishi, S., Jane, D., SUNTER, D., Birse, E. F., UDVARHELYI, P., & Watkins, J. C. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-05-03370.1994 · Cited by 320 · see citing works
N-methyl-D-aspartate receptor antagonist APV blocks acquisition but not expression of fear conditioning.
Kim, J. J., DeCola, J. P., Landeira-Fernández, J., & Fanselow, M. S. (1991) · Behavioral Neuroscience · doi:10.1037/0735-7044.105.1.126 · Cited by 295 · see citing works
Putative Single Quantum and Single Fibre Excitatory Postsynaptic Currents Show Similar Amplitude Range and Variability in Rat Hippocampal Slices
Raastad, M., Storm, J. F., & Andersen, P. N. (1992) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1992.tb00114.x · Cited by 250 · see citing works
Differential localization of phosphoinositide-linked metabotropic glutamate receptor (mGluR1) and the inositol 1,4,5-trisphosphate receptor in rat brain
Fotuhi, M., Sharp, A., Glatt, C., Hwang, P. M., von Krosigk, M., Snyder, S. H., & Dawson, T. M. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-05-02001.1993 · Cited by 247 · see citing works
Presynaptic glutamate receptors depress excitatory monosynaptic transmission between mouse hippocampal neurones.
Forsythe, I. D., & Clements, J. D. (1990) · The Journal of Physiology · doi:10.1113/jphysiol.1990.sp018240 · Cited by 247 · see citing works
Ca2+ Entry via postsynaptic voltage-sensitive Ca2+ channels can transiently potentiate excitatory synaptic transmission in the hippocampus
Kullmann, D. M., Perkei, D. J., Manabe, T., & Nicoll, R. A. (1992) · Neuron · doi:10.1016/0896-6273(92)90075-o · Cited by 237 · see citing works
Quisqualate receptor-mediated depression of calcium currents in hippocampal neurons
Lester, R. A. J., & Jahr, C. E. (1990) · Neuron · doi:10.1016/0896-6273(90)90200-y · Cited by 182 · see citing works
MCPG Antagonizes Metabotropic Glutamate Receptors but not Long‐term Potentiation in the Hippocampus
Manzoni, O. J. J., Weisskopf, M. G., & Nicoll, R. A. (1994) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1994.tb00599.x · Cited by 182 · see citing works
Excitatory effects of ACPD receptor activation in the hippocampus are mediated by direct effects on pyramidal cells and blockade of synaptic inhibition
Desai, M. A., & Conn, P. J. (1991) · Journal of Neurophysiology · doi:10.1152/jn.1991.66.1.40 · Cited by 168 · see citing works
Inhibition of calcium channels in rat CA3 pyramidal neurons by a metabotropic glutamate receptor
Swartz, K., & Bean, B. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-11-04358.1992 · Cited by 163 · see citing works
Phenylglycine derivatives as new pharmacological tools for investigating the role of metabotropic glutamate receptors in the central nervous system
Birse, E. F., Eaton, S. A., Jane, D. E., Jones, P. L., Porter, R. H. P., Pook, P. C. K., Sunter, D. C., Udvarhelyi, P. M., Wharton, B., Roberts‎, P., et al. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90400-a · Cited by 143 · see citing works
Metabotropic glutamate receptors contribute to the induction of long-term depression in the CA1 region of the hippocampus
Bashir, Z. I., Jane, D. E., Sunter, D. C., Watkins, J. C., & Collingridge, G. L. (1993) · European Journal of Pharmacology · doi:10.1016/0014-2999(93)91009-c · Cited by 134 · see citing works
Rundown of N‐methyl‐D‐aspartate channels during whole‐cell recording in rat hippocampal neurons: role of Ca2+ and ATP.
Rosenmund, C., & Westbrook, G. L. (1993) · The Journal of Physiology · doi:10.1113/jphysiol.1993.sp019884 · Cited by 133 · see citing works
Glutamate mediates a slow synaptic response in hippocampal slice cultures
Charpak, S., & Gähwiler, B. H. (1991) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.1991.0035 · Cited by 133 · see citing works
Modulation of calcium currents by a metabotropic glutamate receptor involves fast and slow kinetic components in cultured hippocampal neurons
Sahara, Y., & Westbrook, G. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-07-03041.1993 · Cited by 122 · see citing works
(RS)-alpha-methyl-4-carboxyphenylglycine neither prevents induction of LTP nor antagonizes metabotropic glutamate receptors in CA1 hippocampal neurons
Chinestra, P., Aniksztejn, L., Diabira, D., & Ben‐Ari, Y. (1993) · Journal of Neurophysiology · doi:10.1152/jn.1993.70.6.2684 · Cited by 115 · see citing works
A rise in postsynaptic Ca 2+ potentiates miniature excitatory postsynaptic currents and AMPA responses in hippocampal neurons
Wyllie, D. J. A., Manabe, T., & Nicoll, R. A. (1994) · Neuron · doi:10.1016/0896-6273(94)90158-9 · Cited by 112 · see citing works
Metabotropic glutamate receptor-mediated suppression of L-type calcium current in acutely isolated neocortical neurons
Sayer, R. J., Schwindt, P. C., & Crill, W. E. (1992) · Journal of Neurophysiology · doi:10.1152/jn.1992.68.3.833 · Cited by 107 · see citing works
Glutamate receptor update
Westbrook, G. L. (1994) · Current Opinion in Neurobiology · doi:10.1016/0959-4388(94)90094-9 · Cited by 93 · see citing works
(R,S)-α-Methyl-4-carboxyphenylglycine (MCPG) blocks spatial learning in rats and long-term potentiation in the dentate gyrus in vivo
Riedel, G., Wetzel, W., & Reymann, K. G. (1994) · Neuroscience Letters · doi:10.1016/0304-3940(94)91047-2 · Cited by 76 · see citing works
Glutamate iontophoresis induces long-term potentiation in the absence of evoked presynaptic activity.
Cormier, R., Mauk, M., & Kelly, P. T. (1993) · Neuron · doi:10.1016/0896-6273(93)90206-7 · Cited by 47 · see citing works
Modified Hebbian Rule for Synaptic Enhancement in the Hippocampus and the Visual CortexPreprint
Bonhoeffer, T., Kossel, A. H., Bolz, J., & Aertsen, A. (1990) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1990.055.01.017 · Cited by 13 · see citing works

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Niswender, C. M., & Conn, P. J. (2010) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.011008.145533 · Cited by 1,889 · see citing works
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Tsien, J. Z., Huerta, P. T., & Tonegawa, S. (1996) · Cell · doi:10.1016/s0092-8674(00)81827-9 · Cited by 1,782 · see citing works
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Ozawa, S., Kamiya, H., & Tsuzuki, K. (1998) · Progress in Neurobiology · doi:10.1016/s0301-0082(97)00085-3 · Cited by 1,120 · see citing works
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Shigemoto, R., Kinoshita, A., Wada, E., Nomura, S., Ohishi, H., Takada, M., Flor, P. J., Neki, A., Abe, T., Nakanishi, S., et al. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-19-07503.1997 · Cited by 1,116 · see citing works
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Riedel, G. (2003) · Behavioural Brain Research · doi:10.1016/s0166-4328(02)00272-3 · Cited by 964 · see citing works
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Aiba, A., Kano, M., Chen, C., Stanton, M. E., Fox, G. D., Herrup, K., Zwingman, T. A., & Tonegawa, S. (1994) · Cell · doi:10.1016/0092-8674(94)90205-4 · Cited by 930 · see citing works
Self-citation
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Gerlai, R. (1996) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)20020-7 · Cited by 881 · see citing works
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Tu, J. C., Xiao, B., Yuan, J. P., Lanahan, A. A., Leoffert, K., Li, M., Linden, D. J., & Worley, P. F. (1998) · Neuron · doi:10.1016/s0896-6273(00)80589-9 · Cited by 862 · see citing works
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Anwyl, R. (1999) · Brain Research Reviews · doi:10.1016/s0165-0173(98)00050-2 · Cited by 776 · see citing works
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Fanselow, M. S., & Poulos, A. M. (2005) · Annual Review of Psychology · doi:10.1146/annurev.psych.56.091103.070213 · Cited by 683 · see citing works
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Pin, J.-P., Galvez, T., & Prézeau, L. (2003) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(03)00038-x · Cited by 662 · see citing works
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Matsumoto, M., Nakagawa, T., Inoue, T., Nagata, E., Tanaka, K., Takano, H., Kuno, J., Sakakibara, S., Yamada, M., Yoneshima, H., et al. (1996) · Nature · doi:10.1038/379168a0 · Cited by 485 · see citing works
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Zeeuw, C. I. D., Hoebeek, F. E., Bosman, L. W. J., Schonewille, M., Witter, L., & Koekkoek, S. K. E. (2011) · Nature reviews. Neuroscience · doi:10.1038/nrn3011 · Cited by 411 · see citing works
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Watase, K., Hashimoto, K., Kano, M., Yamada, K., Watanabe, M., Inoue, Y., Okuyama, S., Sakagawa, T., Ogawa, S., Kawashima, N., et al. (1998) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1998.00108.x · Cited by 408 · see citing works
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Self-citation
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Hermans, E., & Challiss, R. A. J. (2001) · Biochemical Journal · doi:10.1042/0264-6021:3590465 · Cited by 402 · see citing works
Hippocampal lesions cause learning deficits in inbred mice in the Morris water maze and conditioned-fear task
Logue, S. F., Paylor, R., & Wehner, J. M. (1997) · Behavioral Neuroscience · doi:10.1037/0735-7044.111.1.104 · Cited by 385 · see citing works
Hippocampal lesions cause learning deficits in inbred mice in the Morris water maze and conditioned-fear task.
Logue, S. F., Paylor, R. E., & Wehner, J. M. (1997) · Behavioral Neuroscience · doi:10.1037//0735-7044.111.1.104 · Cited by 379 · see citing works
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Functional breakdown of the lipid bilayer of the myelin membrane in central and peripheral nervous system by disrupted galactocerebroside synthesis
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Kim, S. J., Kim, Y. S., Yuan, J. P., Petralia, R. S., Worley, P. F., & Linden, D. J. (2003) · Nature · doi:10.1038/nature02162 · Cited by 343 · see citing works
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Miyazaki, T., Fukaya, M., Shimizu, H., & Watanabe, M. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02698.x · Cited by 310 · see citing works
Phospholipase C isozymes selectively couple to specific neurotransmitter receptors
Kim, D., Jun, K. S., Lee, S. B., Kang, N.-G., Min, D. S., Kim, Y.-H., Ryu, S. H., Suh, P.-G., & Shin, H.-S. (1997) · Nature · doi:10.1038/38508 · Cited by 305 · see citing works
Biased Receptor Signaling in Drug Discovery
Kenakin, T. (2019) · Pharmacological Reviews · doi:10.1124/pr.118.016790 · Cited by 302 · see citing works
Persistent Multiple Climbing Fiber Innervationof Cerebellar Purkinje Cellsin Mice Lacking mGluR1
Kano, M., Hashimoto, K., Kurihara, H., Watanabe, M., Inoue, Y., Aiba, A., & Tonegawa, S. (1997) · Neuron · doi:10.1016/s0896-6273(01)80047-7 · Cited by 302 · see citing works
Self-citation
Melanoma mouse model implicates metabotropic glutamate signaling in melanocytic neoplasia
Pollock, P. M., Cohen-Solal, K., Sood, R. B., Namkoong, J., Martino, J. J., Koganti, A., Zhu, H., Robbins, C. M., Makałowska, I., Shin, S., et al. (2003) · Nature Genetics · doi:10.1038/ng1148 · Cited by 301 · see citing works
Molecular genetic analysis of synaptic plasticity, activity-dependent neural development, learning, and memory in the mammalian brain
Chen, C., & Tonegawa, S. (1997) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.20.1.157 · Cited by 300 · see citing works
Group I metabotropic glutamate receptors: implications for brain diseases
Bordi, F., & Ugolini, A. (1999) · Progress in Neurobiology · doi:10.1016/s0301-0082(98)00095-1 · Cited by 294 · see citing works
Memory systems in the brain and localization of a memory
Thompson, R. F., & Kim, J. J. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.24.13438 · Cited by 291 · see citing works
The molecular organization of cerebellar long-term depression
Ito, M. (2002) · Nature reviews. Neuroscience · doi:10.1038/nrn962 · Cited by 288 · see citing works
PI3 kinase enhancer–Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis
Rong, R., Ahn, J.-Y., Huang, H., Nagata, E., Kalman, D., Kapp, J. A., Tu, J., Worley, P. F., Snyder, S. H., & Ye, K. (2003) · Nature Neuroscience · doi:10.1038/nn1134 · Cited by 281 · see citing works
Complex interactions between mGluRs, intracellular Ca2+ stores and ion channels in neurons
Fagni, L., Chavis, P., Ango, F., & Bockaert, J. (2000) · Trends in Neurosciences · doi:10.1016/s0166-2236(99)01492-7 · Cited by 279 · see citing works
staggerer phenotype in retinoid-related orphan receptor α-deficient mice
Steinmayr, M., André, É., Conquet, F., Rondi‐Reig, L., Delhaye‐Bouchaud, N., Auclair, N., Daniel, H., Crépel, F., Mariani, J., Sotelo, C., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.7.3960 · Cited by 273 · see citing works
Nicotinic Stimulation Produces Multiple Forms of Increased Glutamatergic Synaptic Transmission
Radcliffe, K. A., & Dani, J. A. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-18-07075.1998 · Cited by 271 · see citing works
Impaired motor coordination and persistent multiple climbing fiber innervation of cerebellar Purkinje cells in mice lacking Gαq
Offermanns, S., Hashimoto, K., Watanabe, M., Sun, W. Y., Kurihara, H., Thompson, R. F., Inoue, Y., Kano, M., & Simon, M. I. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.25.14089 · Cited by 265 · see citing works
On climbing fiber signals and their consequence(s)
Simpson, J. I., WYLIE, D. R. W., & Zeeuw, C. I. D. (1996) · Behavioral and Brain Sciences · doi:10.1017/s0140525x00081486 · Cited by 247 · see citing works
Disruption of the Oxysterol 7α-Hydroxylase Gene in Mice
Li-Hawkins, J., Lund, E. G., Turley, S. D., & Russell, D. W. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001811200 · Cited by 241 · see citing works
Group 1 and 2 Metabotropic Glutamate Receptors Play Differential Roles in Hippocampal Long-Term Depression and Long-Term Potentiation in Freely Moving Rats
Manahan‐Vaughan, D. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-09-03303.1997 · Cited by 235 · see citing works
Disruption of Cholesterol 7α-Hydroxylase Gene in Mice
Ishibashi, S., Schwarz, M., Frykman, P. K., Herz, J., & Russell, D. W. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.30.18017 · Cited by 233 · see citing works
Selective Abolition of the NMDA Component of Long-Term Potentiation in Mice Lacking mGluR5Preprint
Jia, Z., Lu, Y., Henderson, J., Taverna, F. A., Romano, C., Abramow-Newerly, W., Wojtowicz, J. M., & Roder, J. (1998) · Learning & Memory · doi:10.1101/lm.5.4.331 · Cited by 233 · see citing works
Allosteric Modulation of GPCRs: New Insights and Potential Utility for Treatment of Schizophrenia and Other CNS Disorders
Foster, D. J., & Conn, P. J. (2017) · Neuron · doi:10.1016/j.neuron.2017.03.016 · Cited by 227 · see citing works
Stores Not Just for Storage
Rose, C. R., & Konnerth, A. (2001) · Neuron · doi:10.1016/s0896-6273(01)00402-0 · Cited by 225 · see citing works
A point mutation in TRPC3 causes abnormal Purkinje cell development and cerebellar ataxia in moonwalker mice
Becker, E. B. E., Oliver, P. L., Glitsch, M. D., Banks, G. T., Achilli, F., Hardy, A., Nolan, P. M., Fisher, E., & Davies, K. E. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810599106 · Cited by 223 · see citing works
Metabotropic Glutamate Receptor 1-Induced Upregulation of NMDA Receptor Current: Mediation through the Pyk2/Src-Family Kinase Pathway in Cortical Neurons
Heidinger, V., Manzerra, P., Wang, X. Q., Strasser, U., Yu, S. P., Choi, D. W., & Behrens, M. M. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-13-05452.2002 · Cited by 221 · see citing works
Patterned expression of Purkinje cell glutamate transporters controls synaptic plasticity
Wadiche, J. I., & Jahr, C. E. (2005) · Nature Neuroscience · doi:10.1038/nn1539 · Cited by 220 · see citing works
Metabotropic glutamate receptor ligands as possible anxiolytic and antidepressant drugs
Pałucha-Poniewiera, A., & Pilc, A. (2007) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2007.04.007 · Cited by 220 · see citing works
LONG-TERM POTENTIATION AND LEARNING
Martinez, J. L., & Derrick, B. E. (1996) · Annual Review of Psychology · doi:10.1146/annurev.psych.47.1.173 · Cited by 215 · see citing works
PLC-β1, activated via mGluRs, mediates activity-dependent differentiation in cerebral cortex
Hannan, A. J., Blakemore, C. B., Katsnelson, A., Vitalis, T., Huber, K. M., Bear, M. F., Roder, J., Kim, D., Shin, H., & Kind, P. C. (2001) · Nature Neuroscience · doi:10.1038/85132 · Cited by 214 · see citing works
Metabotropic Glutamate 1 Receptor: Current Concepts and Perspectives
Ferraguti, F., Crepaldi, L., & Nicoletti, F. (2008) · Pharmacological Reviews · doi:10.1124/pr.108.000166 · Cited by 212 · see citing works
Structural Basis for a Ca 2+ -Sensing Function of the Metabotropic Glutamate Receptors
Kubo, Y., Miyashita, T., & Murata, Y. (1998) · Science · doi:10.1126/science.279.5357.1722 · Cited by 212 · see citing works
Reexamination of the effects of MCPG on hippocampal LTP, LTD, and depotentiation
Selig, D. K., Lee, H., Bear, M. F., & Malenka, R. C. (1995) · Journal of Neurophysiology · doi:10.1152/jn.1995.74.3.1075 · Cited by 210 · see citing works
Regulation of metabotropic glutamate receptor signaling, desensitization and endocytosis
Dhami, G. K., & Ferguson, S. S. G. (2006) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2005.01.008 · Cited by 208 · see citing works
Metabotropic Glutamate Receptor Ligands as Potential Therapeutics for Addiction
Olive, M. F. (2009) · Current Drug Abuse Reviews · doi:10.2174/1874473710902010083 · Cited by 201 · see citing works
The Memory-Enhancing Effects of Hippocampal Estrogen Receptor Activation Involve Metabotropic Glutamate Receptor Signaling
Boulware, M. I., Heisler, J. D., & Frick, K. M. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.1716-13.2013 · Cited by 196 · see citing works
Regional distribution of neurotrophin receptors in the developing auditory brainstem
Hafidi, A., Moore, T., & Sanes, D. H. (1996) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19960408)367:3 · Cited by 51 · see citing works
Phospholipase Cβ4 is specifically involved in climbing fiber synapse elimination in the developing cerebellum
Kano, M., Hashimoto, K., Watanabe, M., Kurihara, H., Offermanns, S., Jiang, H., Wu, Y., Jun, K., Shin, H., Inoue, Y., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.26.15724 · Cited by 192 · see citing works
Roles of metabotropic glutamate receptors in LTP and LTD in
Bortolotto, Z. A., Fitzjohn, S. M., & Collingridge, G. L. (1999) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(99)80044-0 · Cited by 192 · see citing works
Brain dystrophin, neurogenetics and mental retardation
Mehler, M. F. (2000) · Brain Research Reviews · doi:10.1016/s0165-0173(99)00090-9 · Cited by 190 · see citing works
SIB-1757 and SIB-1893: Selective, Noncompetitive Antagonists of Metabotropic Glutamate Receptor Type 5
Varney, M. A., Cosford, N. D. P., Jachec, C., Rao, S. P., Sacaan, A. I., Lin, F., Bleicher, L. S., Santori, E. M., Flor, P. J., Allgeier, H., et al. (1999) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)34881-5 · Cited by 189 · see citing works
Synaptic plasticity and cell cycle activation in neurons are alternative effector pathways: the 'Dr. Jekyll and Mr. Hyde concept' of Alzheimer's disease or the yin and yang of neuroplasticity
Arendt, T. (2003) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2003.09.007 · Cited by 188 · see citing works
Toward a Molecular Explanation for Long-Term PotentiationPreprint
Sweatt, J. D. (1999) · Learning & Memory · doi:10.1101/lm.6.5.399 · Cited by 188 · see citing works
Using Knockout and Transgenic Mice to Study Neurophysiology and Behavior
Picciotto, M. R., & Wickman, K. (1998) · Physiological Reviews · doi:10.1152/physrev.1998.78.4.1131 · Cited by 185 · see citing works
Mechanisms underlying cerebellar motor deficits due to mGluR1‐autoantibodies
Coesmans, M., Smitt, P. A. E. S., Linden, D. J., Shigemoto, R., Hirano, T., Yamakawa, Y., van Alphen, A. M., Luo, C., van der Geest, J. N., Kros, J. M., et al. (2002) · Annals of Neurology · doi:10.1002/ana.10451 · Cited by 184 · see citing works
Phenylglycine derivatives discriminate between mGluR1- and mGluR5-mediated responses
Brabet, I., Mary, S., Bockaert, J., & Pin, J. (1995) · Neuropharmacology · doi:10.1016/0028-3908(95)00079-l · Cited by 177 · see citing works
Insight into the function of Group I and Group II metabotropic glutamate (mGlu) receptors: behavioural characterization and implications for the treatment of CNS disorders
Spooren, W. P. J. M., Ballard, T. M., Gasparini, F., Amalric, M., Mutel, V., & Schreiber, R. (2003) · Behavioural Pharmacology · doi:10.1097/01.fbp.0000081783.35927.8f · Cited by 177 · see citing works
Pharmacological Characterization of 1-Aminoindan-1,5-dicarboxylic Acid, a Potent mGluR1 Antagonist
Moroni, F., Lombardi, G., Thomsen, C., Leonardi, P., Attucci, S., Peruginelli, F., Albani-Torregrossa, S., Pellegrini-Giampietro, D. E., Luneia, R., & Pellicciari, R. (1997) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)36672-8 · Cited by 177 · see citing works
Cerebellar long-term depression might normalize excitation of Purkinje cells: a hypothesis
Schutter, E. D. (1995) · Trends in Neurosciences · doi:10.1016/0166-2236(95)93916-l · Cited by 168 · see citing works
Impaired hippocampal plasticity in mice lacking the Cbeta1 catalytic subunit of cAMP-dependent protein kinase.
Qi, M., Zhuo, M., Skålhegg, B. S., Brandon, E. P., Kandel, E. R., McKnight, G. S., & Idzerda, R. L. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.4.1571 · Cited by 167 · see citing works
Quantitative trait locus analysis of contextual fear conditioning in mice
Wehner, J. M., Radcliffe, R. A., Rosmann, S. T., Christensen, S. C., Rasmussen, D. L., Fulker, D. W., & Wiles, M. (1997) · Nature Genetics · doi:10.1038/ng1197-331 · Cited by 163 · see citing works
Ligand-induced rearrangement of the dimeric metabotropic glutamate receptor 1α
Tateyama, M., Abe, H., Nakata, H., Saito, O., & Kubo, Y. (2004) · Nature Structural & Molecular Biology · doi:10.1038/nsmb770 · Cited by 162 · see citing works
Diacylglycerol kinase ɛ regulates seizure susceptibility and long-term potentiation through arachidonoyl– inositol lipid signaling
Turco, E., Tang, W., Topham, M. K., Sakane, F., Marcheselli, V. L., Chen, C., Taketomi, A., Prescott, S. M., & Bazan, N. G. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.081536298 · Cited by 160 · see citing works
GABABReceptors, Monoamine Receptors, and Postsynaptic Inositol Trisphosphate-Induced Ca2+Release Are Involved in the Induction of Long-Term Potentiation at Visual Cortical Inhibitory Synapses
Komatsu, Y. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-20-06342.1996 · Cited by 159 · see citing works
The potent mGlu receptor antagonist LY341495 identifies roles for both cloned and novel mGlu receptors in hippocampal synaptic plasticity
Fitzjohn, S. M., Bortolotto, Z. A., Palmer, M. J., Doherty, A., Ornstein, P. L., Schoepp, D. D., Kingston, A. E., Lodge, D., & Collingridge, G. L. (1998) · Neuropharmacology · doi:10.1016/s0028-3908(98)00145-2 · Cited by 159 · see citing works
Regulation by Metabotropic Glutamate Receptor 5 of LTP in the Dentate Gyrus of Freely Moving Rats: Relevance for Learning and Memory Formation
Naie, K. (2003) · Cerebral Cortex · doi:10.1093/cercor/bhg118 · Cited by 158 · see citing works
Cerebellar plasticity and motor learning deficits in a copy-number variation mouse model of autism
Piochon, C., Kloth, A. D., Grasselli, G., Titley, H. K., Nakayama, H., Hashimoto, K., Wan, V., Simmons, D. H., Eissa, T. L., Nakatani, J., et al. (2014) · Nature Communications · doi:10.1038/ncomms6586 · Cited by 157 · see citing works
Application of an optogenetic byway for perturbing neuronal activity via glial photostimulation
Sasaki, T., Beppu, K., Tanaka, K. F., Fukazawa, Y., Shigemoto, R., & Matsui, K. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1213458109 · Cited by 156 · see citing works
Long-Term Depression: A Cellular Basis for Learning?
Braunewell, K., & Manahan‐Vaughan, D. (2001) · Reviews in the Neurosciences · doi:10.1515/revneuro.2001.12.2.121 · Cited by 157 · see citing works
Get receptive to metabotropic glutamate receptors
Pin, J., & Bockaert, J. (1995) · Current Opinion in Neurobiology · doi:10.1016/0959-4388(95)80047-6 · Cited by 153 · see citing works
Differential Roles for Group 1 mGluR Subtypes in Induction and Expression of Chemically Induced Hippocampal Long-Term Depression
Volk, L. J., Daly, C. A., & Huber, K. M. (2006) · Journal of Neurophysiology · doi:10.1152/jn.00383.2005 · Cited by 150 · see citing works
Quantitative trait loci analysis affecting contextual conditioning in mice
Caldarone, B. J., Saavedra, C., Tartaglia, K., Wehner, J. M., Dudek, B. C., & Flaherty, L. A. (1997) · Nature Genetics · doi:10.1038/ng1197-335 · Cited by 148 · see citing works
Role of metabotropic glutamate receptors in persistent forms of hippocampal plasticity and learning
Mukherjee, S., & Manahan‐Vaughan, D. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.06.005 · Cited by 146 · see citing works
Book Review: Metabotropic Glutamate Receptors: Electrical and Chemical Signaling Properties
Coutinho, V., & Knöpfel, T. (2002) · The Neuroscientist · doi:10.1177/1073858402238514 · Cited by 144 · see citing works
Overexpression of a calcium-binding protein, S100 beta, in astrocytes alters synaptic plasticity and impairs spatial learning in transgenic mice.Preprint
Gerlai, R. T., Wojtowicz, J. M., Marks, A., & Roder, J. (1995) · Learning & Memory · doi:10.1101/lm.2.1.26 · Cited by 143 · see citing works
Metabotropic glutamate receptor 1 (mGluR1) and 5 (mGluR5) regulate late phases of LTP and LTD in the hippocampal CA1 region in vitro
Neyman, S., & Manahan‐Vaughan, D. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06109.x · Cited by 142 · see citing works
Hippocampal lesions impair contextual fear conditioning in two strains of mice.
Chen, C., Kim, J. J., Thompson, R. F., & Tonegawa, S. (1996) · Behavioral Neuroscience · doi:10.1037//0735-7044.110.5.1177 · Cited by 142 · see citing works
Behavioural performance in three substrains of mouse strain 129
Montkowski, A., Poettig, M., Mederer, A., & Holsboer, F. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00370-3 · Cited by 142 · see citing works

Involvement of the mGluR1 Receptor in Hippocampal Synaptic Plasticity and Associative Learning in Behaving Mice
Gil, C., Delgado-García, J. M., Fairén, A. G., & Gruart, A. (2007) · Cerebral Cortex · doi:10.1093/cercor/bhm193 · Cited by 61 · see citing works
Motor deficit and impairment of synaptic plasticity in mice lacking mGluR1
Conquet, F., Bashir, Z. I., Davies, C. H., Daniel, H., Ferraguti, F., Bordi, F., Franz-Bacon, K., Reggiani, A., Matarese, V., Condé, F., et al. (1994) · Nature · doi:10.1038/372237a0 · Cited by 743 · see citing works
Mice Lacking Metabotropic Glutamate Receptor 5 Show Impaired Learning and Reduced CA1 Long-Term Potentiation (LTP) But Normal CA3 LTP
Lu, Y.-M., Jia, Z., Janus, C., Henderson, J. T., Gerlai, R., Wojtowicz, J. M., & Roder, J. C. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-13-05196.1997 · Cited by 634 · see citing works
Pharmacological antagonism of metabotropic glutamate receptor 1 regulates long‐term potentiation and spatial reference memory in the dentate gyrus of freely moving rats via N‐methyl‐ d ‐aspartate and metabotropic glutamate receptor‐dependent mechanisms
Naie, K., & Manahan‐Vaughan, D. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.03864.x · Cited by 72 · see citing works
Deficient cerebellar long-term depression and impaired motor learning in mGluR1 mutant mice
Aiba, A., Kano, M., Chen, C., Stanton, M. E., Fox, G. D., Herrup, K., Zwingman, T. A., & Tonegawa, S. (1994) · Cell · doi:10.1016/0092-8674(94)90205-4 · Cited by 930 · see citing works
Self-citation

Authors: Aiba, A.
Affiliations: Howard Hughes Medical Institute (US)
Corresponding author: Aiba, A
ORCID: Aiba, A
Venue: Cell
Publisher: Elsevier BV
Published: 1994-10-21
Volume: 79
Issue: 2
Pages: 365-375
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/0092-8674(94)90204-6
OpenAlex: W1983956991
Cited by: 614
References: 49
Citations by year: 2026: 3 · 2025: 2 · 2024: 1 · 2023: 7 · 2022: 10 · 2021: 13 · 2020: 14 · 2019: 11 · 2018: 5 · 2017: 9 · 2016: 14 · 2015: 14 · 2014: 13 · 2013: 12 · 2012: 21
FWCI: 16.15
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
Rare & Special e-Zone (The Hong Kong University of Science and Technology) (submittedVersion)
Funders: National Institute of Neurological Disorders and Stroke (R01 NS32925, R01NS020591, NS20591, R01NS032925)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Keywords: metabotropic glutamate receptor 1, hippocampal long-term potentiation, hippocampal CA1, synaptic plasticity, long-term depression, short-term potentiation, excitatory synaptic transmission, learning disabilities
MeSH terms: Animals, Base Sequence, Electric Stimulation, Female, Genes, Hippocampus, Male, Mice, Inbred C57BL, Molecular Sequence Data, Synaptic Transmission, Neuronal Plasticity, Restriction Mapping, Receptors, Glutamate, Long-Term Potentiation, DNA Primers, Mice, Knockout, Mice, In Vitro Techniques

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Reduced hippocampal long-term potentiation and context-specific deficit in associative learning in mGluR1 mutant mice.

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