The DOI matches its Crossref record; 124 of the 124 references it cites were found in a registry or an index.
CYCLINS AND CELL CYCLE CHECKPOINTS
Abstract
▪ Abstract The eucaryotic cell cycle is regulated by the periodic synthesis and destruction of cyclins that associate with and activate cyclin-dependent kinases. Cyclin-dependent kinase inhibitors, such as p21 and p16, also play important roles in cell cycle control by coordinating internal and external signals and impeding proliferation at several key checkpoints. Understanding how these proteins interact to regulate the cell cycle has become increasingly important to researchers and clinicians with the discovery that many of the genes that encode cell cycle regulatory activities are targets for alterations that underlie the development of cancer. Several therapeutic agents, such as DNA-damaging drugs, microtubule inhibitors, antimetabolites, and topoisomerase inhibitors, take advantage of this disruption in normal cell cycle regulation to target checkpoint controls and ultimately induce growth arrest or apoptosis of neoplastic cells. Other therapeutic drugs being developed, such as UCN-01, specifically inhibit cell cycle regulatory proteins.
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Cites
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A cell cycle regulator potentially involved in genesis of many tumor types
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BackgroundG1 phase progression: Cycling on cue
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Cited by
Intrinsically unstructured proteins: re-assessing the protein structure-function paradigm
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Extensive and coordinated transcription of noncoding RNAs within cell-cycle promoters
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Immunity, inflammation and cancer: a leading role for adenosine
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Denison, M. S., Soshilov, A. A., He, G., DeGroot, D. E., & Zhao, B. (2011) · Toxicological Sciences · doi:10.1093/toxsci/kfr218 · Cited by 748
Common markers of proliferation
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Metadata
- Authors
- Johnson, D. G., & Walker, C. L.
- Venue
- Annual Review of Pharmacology and Toxicology
- Publisher
- Annual Reviews
- Published
- 1999-04
- Volume
- 39
- Issue
- 1
- Pages
- 295-312
- ISSN
- 0362-1642 (ISSN-L)
- 1545-4304
- OpenAlex
- W2111420633
- Cited by
- 719
- References
- 124
- FWCI
- 2.47
- Type
- journal article
- Language
- en
- Open access
- closed
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- Johnson, D. G., & Walker, C. L. (1999). CYCLINS AND CELL CYCLE CHECKPOINTS. Annual Review of Pharmacology and Toxicology. https://doi.org/10.1146/annurev.pharmtox.39.1.295
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
