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Pharmacology of Cloned P2X Receptors
Abstract
There are seven P2X receptor cDNAs currently known. Six homomeric (P2X 1, P2X 2, P2X 3, P2X 4, P2X 5, P2X 7) and three heteromeric (P2X 2/P2X 3, P2X 4/P2X 6, P2X 1/P2X 5) P2X receptor channels have been characterized in heterologous expression systems. Homomeric P2X 1 and P2X 3 receptors are readily distinguishable by their rapid desensitization, the agonist action of αβmethyleneATP, and the block by 2′,3′-O-(2,4,6-trinitrophenyl)-ATP. P2X 2 receptors are unique among homomeric forms in their potentiation by low pH. Homomeric P2X 4 receptors are much less sensitive to antagonism by suramin and pyridoxal 5-phosphate-6-azo-2′,4′-disulfonic acid. Homomeric P2X 7 receptors are the only form in which 2′,3′-O-(4-benzoylbenzoyl)-ATP is more potent than ATP. The heteromeric P2X 2/P2X 3 receptor resembles P2X 2 in slow desensitization kinetics and potentiation by low pH and is similar to P2X 3 with respect to agonism by αβmethyleneATP and block by 2′,3′-O-(2,4,6-trinitrophenyl)-ATP. Other agonists, antagonists, and ions that can be used to differentiate among the receptors are discussed.
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Cites
Molecular cloning and characterization of the rat NMDA receptor
Moriyoshi, K., Masu, M., Ishii, T., Shigemoto, R., Mizuno, N., & Nakanishi, S. (1991) · Nature · doi:10.1038/354031a0 · Cited by 1,771
A Family of AMPA-Selective Glutamate Receptors
Keinänen, K., Wisden, W., Sommer, B., Werner, P., Herb, A., Verdoorn, T. A., Sakmann, B., & Seeburg, P. H. (1990) · Science · doi:10.1126/science.2166337 · Cited by 1,479
Cited by
Molecular Physiology of P2X Receptors
North, R. A. (2002) · Physiological Reviews · doi:10.1152/physrev.00015.2002 · Cited by 2,919
Self-citationP2X 7 Receptor-Mediated Release of Excitatory Amino Acids from Astrocytes
Duan, S., Anderson, C. M., Keung, E. C., Chen, Y., Chen, Y., & Swanson, R. A. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-04-01320.2003 · Cited by 489
Pattern recognition receptors and central nervous system repair
Kigerl, K. A., de Rivero Vaccari, J. P., Dietrich, W. D., Popovich, P. G., & Keane, R. W. (2014) · Experimental Neurology · doi:10.1016/j.expneurol.2014.01.001 · Cited by 490
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Suzuki, T., Hide, I., Ido, K., Kohsaka, S., Inoue, K., & Nakata, Y. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.3792-03.2004 · Cited by 394
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Khakh, B. S. (2001) · Nature Reviews Neuroscience · doi:10.1038/35058521 · Cited by 363
Metadata
- Authors
- North, R. A., & Surprenant, A.
- Venue
- Annual Review of Pharmacology and Toxicology
- Publisher
- Annual Reviews
- Published
- 2000-04
- Volume
- 40
- Issue
- 1
- Pages
- 563-580
- ISSN
- 0362-1642 (ISSN-L)
- 1545-4304
- OpenAlex
- W2140327830
- Cited by
- 701
- References
- 2
- FWCI
- 4.02
- Type
- journal article
- Language
- en
- Open access
- closed
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