Cited by 1,771Neuroscience and Neuropharmacology ResearchAmino Acid Enzymes and MetabolismReceptor Mechanisms and Signaling

Molecular cloning and characterization of the rat NMDA receptor

Moriyoshi, Koki, Masu, Masayuki, Ishii, Takahiro, Shigemoto, Ryuichi, Mizuno, Noboru, Nakanishi, Shigetada·1991·Nature

Abstract

A complementary DNA encoding the rat NMDA receptor has been cloned and characterized. The single protein encoded by the cDNA forms a receptor-channel complex that has electrophysiological and pharmacological properties characteristic of the NMDA receptor. This protein has a significant sequence similarity to the AMPA/kainate receptors and contains four putative transmembrane segments following a large extracellular domain. The NMDA receptor messenger RNA is expressed in neuronal cells throughout the brain regions, particularly in the hippocampus, cerebral cortex and cerebellum.

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Crossref · 10.1038/354031a0

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Authors
Moriyoshi, K., Masu, M., Ishii, T., Shigemoto, R., Mizuno, N., & Nakanishi, S.
Affiliations
Kyoto University (JP)
Venue
Nature
Published
1991-11-07
Volume
354
Issue
6348
Pages
31-37
ISSN
  • 0028-0836 (ISSN-L)
  • 1476-4687
OpenAlex
W2059334396
Cited by
1,771
References
0
Citations by year
2026: 4 · 2025: 3 · 2024: 7 · 2023: 19 · 2022: 15 · 2021: 12 · 2020: 21 · 2019: 22 · 2018: 22 · 2017: 20 · 2016: 14 · 2015: 26 · 2014: 28 · 2013: 18 · 2012: 27
FWCI
53.95
Type
journal article
Language
en
Open access
closed
Locations
  • Nature (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
Keywords
NMDA receptor, rats, cDNA cloning, transmembrane helices, extracellular domain, mRNA expression, hippocampus, cerebral cortex, cerebellum, neurons
MeSH terms
Amino Acid Sequence, Animals, Base Sequence, Brain, Cloning, Molecular, Electrophysiology, Ibotenic Acid, Kainic Acid, Molecular Sequence Data, RNA, Messenger, Xenopus, Molecular Structure, Receptors, N-Methyl-D-Aspartate, alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid, Rats

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