The DOI matches its Crossref record; 199 of the 199 references it cites were found in a registry or an index.
EVALUATION OF DRUG-DRUG INTERACTION IN THE HEPATOBILIARY AND RENAL TRANSPORT OF DRUGS
Abstract
Recent studies have revealed the import role played by transporters in the renal and hepatobiliary excretion of many drugs. These transporters exhibit a broad substrate specificity with a degree of overlap, suggesting the possibility of transporter-mediated drug-drug interactions with other substrates. This review is an overview of the roles of transporters and the possibility of transporter-mediated drug-drug interactions. Among the large number of transporters, we compare the Ki values of inhibitors for organic anion transporting polypeptides (OATPs) and organic anion transporters (OATs) and their therapeutic unbound concentrations. Among them, cephalosporins and probenecid have the potential to produce clinically relevant OAT-mediated drug-drug interactions, whereas cyclosporin A and rifampicin may trigger OATP-mediated ones. These drugs have been reported to cause drug-drug interactions in vivo with OATs or OATP substrates, suggesting the possibility of transporter-mediated drug-drug interactions. To avoid adverse consequences of such transporter-mediated drug-drug interactions, we need to be more aware of the role played by drug transporters as well as those caused by drug metabolizing enzymes.
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“In the disposition process, transporters and enzymes play a key role by interacting with each other [86].”
From Interpretation of Non-Clinical Data for Prediction of Human Pharmacokinetic Parameters: In Vitro-In Vivo Extrapolation and Allometric Scaling (2019) · cites this paper as [86]
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Metadata
- Authors
- Shitara, Y., Sato, H., & Sugiyama, Y.
- Affiliations
- SHOWA Medical University (JP)
- The University of Tokyo (JP)
- Venue
- Annual Review of Pharmacology and Toxicology
- Publisher
- Annual Reviews
- Published
- 2005-09-22
- Volume
- 45
- Issue
- 1
- Pages
- 689-723
- ISSN
- 0362-1642 (ISSN-L)
- 1545-4304
- OpenAlex
- W2066382275
- Cited by
- 336
- References
- 199
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 4 · 2023: 5 · 2022: 5 · 2021: 11 · 2020: 8 · 2019: 7 · 2018: 9 · 2017: 14 · 2016: 15 · 2015: 12 · 2014: 14 · 2013: 23 · 2012: 25
- FWCI
- 2.12
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Annual Review of Pharmacology and Toxicology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Interaction Studies and Fluorescence Analysis
- Keywords
- drug-drug interactions, drug transporters, renal drug excretion, organic anion transporting polypeptides, organic anion transporters, transporter inhibitors, Ki values, substrate specificity, probenecid, cephalosporins, cyclosporine, rifampicin, drug-metabolizing enzymes
- MeSH terms
- Animals, Biliary Tract, Biological Transport, Drug Evaluation, Drug Interactions, Pharmaceutical Preparations, Humans, Kidney, Liver
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