Sugiyama, Yuichi

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME

Godoy, P., Hewitt, N. J., Albrecht, U., Andersen, M. E., Ansari, N., Bhattacharya, S., Bode, J. G., Bolleyn, J., Borner, C., Böttger, J., et al. (2013) · Archives of Toxicology

Drug-Induced Hepatotoxicity and ProtectionLiver physiology and pathology

Cited by 1,280

Prediction of in vivo drug metabolism in the human liver from in vitro metabolism data

Iwatsubo, T., Hirota, N., Ooie, T., Suzuki, H., Shimada, N., Chiba, K., Ishizaki, T., Green, C. E., Tyson, C. A., & Sugiyama, Y. (1997) · Pharmacology & Therapeutics

Pharmacogenetics and Drug MetabolismDrug-Induced Hepatotoxicity and Protection

Cited by 479

Involvement of organic cation transporter 1 in hepatic and intestinal distribution of metformin

Wang, D.-S., Jonker, J. W., Kato, Y., Kusuhara, H., Schinkel, A. H., & Sugiyama, Y. (2002) · The Journal of Pharmacology and Experimental Therapeutics

Drug Transport and Resistance MechanismsPharmacogenetics and Drug Metabolism

Cited by 441

EVALUATION OF DRUG-DRUG INTERACTION IN THE HEPATOBILIARY AND RENAL TRANSPORT OF DRUGS

Shitara, Y., Sato, H., & Sugiyama, Y. (2005) · Annual Review of Pharmacology and Toxicology

Drug Transport and Resistance MechanismsPharmacogenetics and Drug Metabolism

Cited by 336

Functional Characterization of Rat Brain-specific Organic Anion Transporter (Oatp14) at the Blood-Brain Barrier

Sugiyama, D., Kusuhara, H., Taniguchi, H., Ishikawa, S., Nozaki, Y., Aburatani, H., & Sugiyama, Y. (2003) · Journal of Biological Chemistry

Drug Transport and Resistance MechanismsBarrier Structure and Function Studies

Cited by 283

Apical/Basolateral Surface Expression of Drug Transporters and its Role in Vectorial Drug Transport

Ito, K., Suzuki, H., Horie, T., & Sugiyama, Y. (2005) · Pharmaceutical Research

Drug Transport and Resistance MechanismsPharmacogenetics and Drug Metabolism

Cited by 174

Functional Characterization of Mouse Organic Anion Transporting Peptide 1a4 in the Uptake and Efflux of Drugs Across the Blood-Brain Barrier

Ose, A., Kusuhara, H., Endo, C., Tohyama, K., Miyajima, M., Kitamura, S., & Sugiyama, Y. (2010) · Drug Metabolism and Disposition

Drug Transport and Resistance MechanismsBarrier Structure and Function Studies

Cited by 148

Bezafibrate stimulates canalicular localization of NBD-labeled PC in HepG2 cells by PPARα-mediated redistribution of ABCB4

Shoda, J., Inada, Y., Tsuji, A., Kusama, H., Ueda, T., Ikegami, T., Suzuki, H., Sugiyama, Y., Cohen, D. E., & Tanaka, N. (2004) · Journal of Lipid Research

Drug Transport and Resistance MechanismsCholesterol and Lipid Metabolism

Cited by 58

Comparison of Methods for Estimating Unbound Intracellular-to-Medium Concentration Ratios in Rat and Human Hepatocytes Using Statins

Yoshikado, T., Toshimoto, K., Nakada, T., Ikejiri, K., Kusuhara, H., Maeda, K., & Sugiyama, Y. (2017) · Drug Metabolism and Disposition

Drug Transport and Resistance MechanismsPharmacogenetics and Drug Metabolism

Cited by 54

High-Affinity Efflux Transport System for Glutathione Conjugates on the Luminal Membrane of a Mouse Brain Capillary Endothelial Cell Line (MBEC4)

Homma, M., Suzuki, H., Kusuhara, H., Naito, M., Tsuruo, T., & Sugiyama, Y. (1999) · The Journal of Pharmacology and Experimental Therapeutics

Drug Transport and Resistance MechanismsBarrier Structure and Function Studies

Cited by 44

Estimation of the Interindividual Variability of Cytochrome 2D6 Activity from Urinary Metabolic Ratios in the Literature

Ito, T., Kato, M., Chiba, K., Okazaki, O., & Sugiyama, Y. (2010) · Drug Metabolism and Pharmacokinetics

Pharmacogenetics and Drug MetabolismDrug Transport and Resistance Mechanisms

Cited by 23

Phase 0, including microdosing approaches: applying the three Rs and increasing the efficiency of human drug development

Burt, T., Vuong, L. T., Baker, E., Young, G. C., McCartt, A. D., Bergstrom, M., Sugiyama, Y., & Combes, R. (2018) · Alternatives to Laboratory Animals

Statistical Methods in Clinical TrialsPharmaceutical studies and practices

Cited by 18