The DOI matches its Crossref record; 139 of the 139 references it cites were found in a registry or an index.
Sex-Based Cardiac Physiology
Abstract
Biological sex plays an important role in normal cardiac physiology as well as in the heart's response to cardiac disease. Women generally have better cardiac function and survival than do men in the face of cardiac disease; however, this sex difference is lost when comparing postmenopausal women with age-matched men. Animal models of cardiac disease mirror what is seen in humans. Sex steroid hormones contribute significantly to sex-based differences in cardiac disease outcomes. Estrogen is generally considered to be cardioprotective, whereas testosterone is thought to be detrimental to heart function. Environmental estrogen-like molecules, such as phytoestrogens, can also affect cardiac physiology in both a positive and a negative manner.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Likewise, sex hormones are thought to play an important role in the development of cardiovascular diseases [19–21].”
From Intestinal Microbiota Is Influenced by Gender and Body Mass Index (2016) · cites this paper as [21]
Citations
Cites
Writing Group for the Women's Health Initiative Investigators (2002) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.288.3.321 · Cited by 15,889
Lamb, J., Crawford, E. D., Peck, D., Modell, J. W., Blat, I. C., Wrobel, M. J., Lerner, J., Brunet, J.-P., Subramanian, A., Ross, K. N., et al. (2006) · Science · doi:10.1126/science.1132939 · Cited by 5,257
Therapeutic potential of resveratrol: the in vivo evidence
Baur, J. A., & Sinclair, D. A. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd2060 · Cited by 3,958
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
Howitz, K. T., Bitterman, K. J., Cohen, H. Y., Lamming, D. W., Lavu, S., Wood, J. G., Zipkin, R. E., Chung, P., Kisielewski, A., Zhang, L.-L., et al. (2003) · Nature · doi:10.1038/nature01960 · Cited by 3,796
Elevated Circulating Levels of Tumor Necrosis Factor in Severe Chronic Heart Failure
Levine, B., Kalman, J., Mayer, L., Fillit, H. M., & Packer, M. (1990) · New England Journal of Medicine · doi:10.1056/nejm199007263230405 · Cited by 2,582
Estrogen Receptor Null Mice: What Have We Learned and Where Will They Lead Us?
Couse, J. F., & Korach, K. S. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.3.0370 · Cited by 2,045
Survival after the onset of congestive heart failure in Framingham Heart Study subjects.
Ho, K. K. L., Anderson, K. M., Kannel, W. B., Grossman, W., & Levy, D. A. (1993) · Circulation · doi:10.1161/01.cir.88.1.107 · Cited by 1,865
Biological effects of resveratrol
Frémont, L. (2000) · Life Sciences · doi:10.1016/s0024-3205(99)00410-5 · Cited by 1,663
Geisterfer-Lowrance, A. A. T., Kass, S., Tanigawa, G., Vosberg, H.-P., McKenna, W., Seidman, C. E., & Seidman, J. G. (1990) · Cell · doi:10.1016/0092-8674(90)90274-i · Cited by 1,380
Sex-Based Differences in Early Mortality after Myocardial Infarction
Vaccarino, V., Parsons, L. S., Every, N. R., Barron, H. V., & Krumholz, H. M. (1999) · New England Journal of Medicine · doi:10.1056/nejm199907223410401 · Cited by 1,301
Research works printed but not linked: 5
- Zak R, 1974, Circ. Res., 35, 17
- Fernandez-Sola J, 2002, J. Gend. Specif. Med., 5, 41
- Mole PA, 1978, Am. J. Physiol., 234, H421
- 10.1210/jc.80.7.2163 · DOI
- Thigpen JE, 1999, Lab. Anim. Sci., 49, 530
Cited by
Sorted by citations
Bernardo, B. C., Weeks, K. L., Pretorius, L., & McMullen, J. R. (2010) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2010.04.005 · Cited by 920
Intestinal Microbiota Is Influenced by Gender and Body Mass Index
Haro, C., Rangel-Zúñiga, O. A., Alcalá-Díaz, J. F., Gómez-Delgado, F., Pérez-Martínez, P., Delgado-Lista, J., Quintana-Navarro, G. M., Landa, B. B., Navas-Cortés, J. A., Tena-Sempere, M., et al. (2016) · PLOS ONE · doi:10.1371/journal.pone.0154090 · Cited by 671
Liu, C., Liu, Y.-C., Wu, C. O., Armstrong, A. D. C., Volpe, G. J., van der Geest, R. J., Liu, Y., Hundley, W. G., Gomes, A. S., Liu, S., et al. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.05.078 · Cited by 349
Molecular Mechanisms Underlying Cardiac Adaptation to Exercise
Vega, R. B., Konhilas, J. P., Kelly, D. P., & Leinwand, L. A. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.04.025 · Cited by 312
Sex and gender differences in control of blood pressure
Maranon, R. O., & Reckelhoff, J. F. (2013) · Clinical Science · doi:10.1042/cs20130140 · Cited by 267
Metadata
- Authors
- Luczak, E. D., & Leinwand, L. A.
- Affiliations
- University of Colorado Boulder (US)
- Venue
- Annual Review of Physiology
- Publisher
- Annual Reviews
- Published
- 2009-03-01
- Volume
- 71
- Issue
- 1
- Pages
- 1-18
- ISSN
- 0066-4278 (ISSN-L)
- 1545-1585
- OpenAlex
- W2107190331
- Cited by
- 143
- References
- 135
- Citations by year
- 2026: 5 · 2025: 3 · 2024: 8 · 2023: 10 · 2022: 5 · 2021: 12 · 2020: 7 · 2019: 10 · 2018: 4 · 2017: 10 · 2016: 8 · 2015: 12 · 2014: 8 · 2013: 13 · 2012: 8
- FWCI
- 1.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Physiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Sex and Gender in Healthcare
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Keywords
- sex differences, cardiac physiology, sex hormones, estrogen, testosterone, phytoestrogens, postmenopausal women, heart disease, cardioprotection
- MeSH terms
- Animals, Disease Models, Animal, Estrogens, Female, Heart, Heart Diseases, Humans, Male, Sex Characteristics, Testosterone, Phytoestrogens, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
