The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
CHOLECYSTOKININ CELLS
Abstract
▪ Abstract Cholecystokinin (CCK) is an important hormonal regulator of the digestive process. CCK cells are concentrated in the proximal small intestine, and hormone is secreted into the blood upon the ingestion of food. The physiological actions of CCK include stimulation of pancreatic secretion and gallbladder contraction, regulation of gastric emptying, and induction of satiety. Therefore, in a highly coordinated manner, CCK regulates the ingestion, digestion, and absorption of nutrients. CCK is produced by two separate cell types: endocrine cells of the small intestine and various neurons in the gastrointestinal tract and central nervous system. Accordingly, CCK can function as either a hormone or a neuropeptide. This review focuses on the physiology of the CCK cell in the intestine and, in particular, on how the CCK cell is regulated to secrete its hormone product. The effects of ingested nutrients on the CCK cell and the intracellular messenger systems involved in controlling secretion are reviewed. A summary is provided of recent studies examining the electrophysiological properties of CCK cells and newly discovered proteins that act as releasing factors for CCK, which mediate feedback pathways critical for regulated secretion in the intact organism.
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Citations
Cites
Cholecystokinin decreases food intake in rats.
Gibbs, J., Young, R. C., & Smith, G. P. (1973) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0034870 · Cited by 1,491
Rehfeld, J. F. (1978) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)34793-2 · Cited by 807
Liddle, R. A., Goldfine, I. D., Rosen, M. S., Taplitz, R. A., & Williams, J. A. (1985) · Journal of Clinical Investigation · doi:10.1172/jci111809 · Cited by 745
Self-citationA HORMONE MECHANISM FOR GALL-BLADDER CONTRACTION AND EVACUATION
Ivy, A. C., & Oldberg, E. (1928) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1928.86.3.599 · Cited by 691
Larsson, L.-I., & Rehfeld, J. F. (1979) · Brain Research · doi:10.1016/0006-8993(79)90554-7 · Cited by 663
Expression cloning and characterization of the canine parietal cell gastrin receptor.
Kopin, A. S., Lee, Y. M., McBride, E. W., Miller, L. J., Lu, M., Lin, H. Y., Kolakowski, L. F., & Beinborn, M. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.8.3605 · Cited by 508
Structure of Porcine Cholecystokinin‐Pancreozymin: 1. Cleavage with Thrombin and with Trypsin
Mutt, V., & Jorpes, J. E. (1968) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1968.tb00433.x · Cited by 504
Pancreozymin, a stimulant of the secretion of pancreatic enzymes in extracts of the small intestine
Harper, A. A., & Raper, H. S. (1943) · The Journal of Physiology · doi:10.1113/jphysiol.1943.sp004021 · Cited by 450
Bioassay of plasma cholecystokinin in rats: Effects of food, trypsin inhibitor, and alcohol
Liddle, R. A., Goldfine, I. D., & Williams, J. A. (1984) · Gastroenterology · doi:10.1016/0016-5085(84)90524-9 · Cited by 410
Self-citationWank, S. A., Harkins, R., Jensen, R. T., Shapira, H., de Weerth, A., & Slattery, T. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.7.3125 · Cited by 403
Cited by
Steinert, R. E., Feinle-Bisset, C., Asarian, L., Horowitz, M., Beglinger, C., & Geary, N. (2017) · Physiological Reviews · doi:10.1152/physrev.00031.2014 · Cited by 578
Sulfonation and molecular action
Strott, C. A. (2002) · Endocrine Reviews · doi:10.1210/er.2001-0040 · Cited by 487
DIETARY FIBER AND BODY-WEIGHT REGULATION
Pereira, M. A., & Ludwig, D. S. (2001) · Pediatric Clinics of North America · doi:10.1016/s0031-3955(05)70351-5 · Cited by 372
Protective mechanisms of the Mediterranean diet in obesity and type 2 diabetes
Schröder, H. (2007) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2006.05.006 · Cited by 337
Egerod, K. L., Engelstoft, M. S., Grunddal, K. V., Nøhr, M. K., Secher, A., Sakata, I., Pedersen, J., Windeløv, J. A., Füchtbauer, E.-M., Olsen, J., et al. (2012) · Endocrinology · doi:10.1210/en.2012-1595 · Cited by 334
Metadata
- Authors
- Liddle, R. A.
- Venue
- Annual Review of Physiology
- Publisher
- Annual Reviews
- Published
- 1997-10
- Volume
- 59
- Issue
- 1
- Pages
- 221-242
- ISSN
- 0066-4278 (ISSN-L)
- 1545-1585
- OpenAlex
- W4254656354
- Cited by
- 280
- References
- 49
- FWCI
- 0.43
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
