Origin and steady-state turnover of class II MHC-bearing dendritic cells in the epithelium of the conducting airways.
Abstract
Recent studies have identified a contiguous network of class II MHC-bearing dendritic cells (DC) in the airway epithelium of several species, including humans. This network seems comparable to the epidermal Langerhans cell population, comprising up to 700 DC per mm2 of airway epithelium. Moreover, it accounts for virtually all local immunostaining for class II MHC, suggesting an important role in surveillance for inhaled Ag. This study examines the turnover of these airway DC using a radiation chimera model that uses congenic rats expressing different allotypic variants of CD45, detectable via mAbs. Steady-state bone marrow renewal of the airway DC population (which is continuously depleted by migration of mature cells to draining lymph nodes) was interrupted via x-irradiation or high-dose dexamethasone, after which the resident population declined by 85% over the ensuing 72 h. After transplantation with congenic bone marrow and an initial lag period for graft establishment, the airway DC population was rapidly restored to preirradiation levels. These findings indicate a half-life of < or = 2 days for airway epithelial DC. In contrast, epidermal Langerhans cell half-life was > or = 15 days. The only comparable (short) half-life previously reported for a peripheral tissue DC population, is that derived from the gut wall. This indicates that rapidly turning over DC populations are a unique feature of the major "mucosal" organ systems, which is consistent with these DC playing an important role in surveillance of mucosal tissues for incoming Ag.
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Many clinical studies have identified positive associations between levels of airway epithelial cell-derived inflammatory mediators and disease severity.
“Many clinical studies have identified positive associations between levels of airway epithelial cell-derived inflammatory mediators and disease severity.”
From The airway epithelium: soldier in the fight against respiratory viruses (2011) · cites this paper as [114]
Dose-related associations were found between several cytokines and chemokines (including IL-8/CXLC8, MIP-1α/CCL3, MCP-1/CCL2, and the IL-6/TNF-α ratio) in respiratory secretions and the severity of RSV bronchiolitis.
“For instance, dose-related associations were found between several cytokines and chemokines (including IL-8/CXLC8, MIP-1α/CCL3, MCP-1/CCL2, and the IL-6/TNF-α ratio) in respiratory secretions and the severity of RSV bronchiolitis (76, 114, 271)”
From The airway epithelium: soldier in the fight against respiratory viruses (2011) · cites this paper as [114]
The associations between inflammatory mediators and RSV bronchiolitis severity suggest a relationship between overly aggressive innate immune responses and disease following infection.
“suggesting a relationship between overly aggressive innate immune responses and disease following infection.”
From The airway epithelium: soldier in the fight against respiratory viruses (2011) · cites this paper as [114]
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Stumbles, P. A., Thomas, J. A., Pimm, C. L., Lee, P. T., Venaille, T. J., Proksch, S., & Holt, P. G. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.11.2019 · Cited by 464 · see citing works
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Jakubzick, C., Bogunovic, M., Bonito, A. J., Kuan, E. L., Mérad, M., & Randolph, G. J. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20081430 · Cited by 226 · see citing works
Jakubzick, C. V., Tacke, F., Ginhoux, F., Wagers, A., van Rooijen, N., Mack, M., Merad, M., & Randolph, G. (2008) · Journal of Immunology · doi:10.4049/jimmunol.180.5.3019 · Cited by 263 · see citing works
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Jahnsen, F. L., Strickland, D. H., Thomas, J. A., Tobagus, I. T., Napoli, S., Zosky, G. R., Turner, D. J., Sly, P. D., Stumbles, P. A., & Holt, P. G. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.9.5861 · Cited by 213 · see citing works
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Villadangos, J. A., & Heath, W. R. (2005) · Seminars in Immunology · doi:10.1016/j.smim.2005.05.015 · Cited by 171 · see citing works
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Xia, W., Carvalho-Pinto, C. E., & Kradin, R. L. (1995) · The Journal of Experimental Medicine · doi:10.1084/jem.181.4.1275 · Cited by 163 · see citing works
Nardelli‐Haefliger, D., Roden, R. B. S., Benyacoub, J., Sahli, R., Kraehenbühl, J. P., Schiller, J. T., Lachat, P., Potts, A., & Grandi, P. D. (1997) · Infection and Immunity · doi:10.1128/iai.65.8.3328-3336.1997 · Cited by 160 · see citing works
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Suri, H. S., Yi, E. S., Nowakowski, G. S., et al. (2012) · Orphanet Journal of Rare Diseases · doi:10.1186/1750-1172-7-16 · Cited by 157 · see citing works
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Cavanagh, L. L., & von Andrian, U. H. (2002) · Immunology and Cell Biology · doi:10.1046/j.1440-1711.2002.01119.x · Cited by 153 · see citing works
Rare diseases bullet 9: Adult pulmonary Langerhans' cell histiocytosis
Tazi, A. (2000) · Thorax · doi:10.1136/thorax.55.5.405 · Cited by 153 · see citing works
Hussell, T., Spender, L. C., Georgiou, A., et al. (1996) · Journal of General Virology · doi:10.1099/0022-1317-77-10-2447 · Cited by 153 · see citing works
Ishida, T., Oyama, T., Carbone, D. P., & Gabrilovich, D. I. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.9.4842 · Cited by 150 · see citing works
Characterization of Murine Lung Dendritic Cells Infected withMycobacterium tuberculosis
Juarrero, M. G., & Orme, I. M. (2001) · Infection and Immunity · doi:10.1128/iai.69.2.1127-1133.2001 · Cited by 150 · see citing works
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Lung defences: an overview: TABLE 1—
Nicod, L. P. (2005) · European Respiratory Review · doi:10.1183/09059180.05.00009501 · Cited by 139 · see citing works
Identification of a radio-resistant and cycling dermal dendritic cell population in mice and men
Bogunovic, M., Ginhoux, F., Wagers, A. J., Loubeau, M., Isola, L. M., Lubrano, L., Najfeld, V., Phelps, R. G., Grosskreutz, C. L., Scigliano, E., et al. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20060667 · Cited by 140 · see citing works
Lung dendritic cells and host immunity to infection
Lambrecht, B. N., Prins, J., & Hoogsteden, H. C. (2001) · European Respiratory Journal · doi:10.1183/09031936.01.18040692 · Cited by 140 · see citing works
“airways into the draining lymph nodes [6, 34].”
BackgroundDendritic cell subsets and immune regulation in the lung
de Heer, H. J., Hammad, H., Kool, M., & Lambrecht, B. N. (2005) · Seminars in Immunology · doi:10.1016/j.smim.2005.05.002 · Cited by 135 · see citing works
Tunon‐de‐Lara, J. M., Redington, A. E., Bradding, P. H., Church, M. K., Hartley, J. A., Semper, A. E., & Holgate, S. T. (1996) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.1996.tb00591.x · Cited by 138 · see citing works
Ontogeny and homeostasis of Langerhans cells
Ginhoux, F., & Mérad, M. (2010) · Immunology and Cell Biology · doi:10.1038/icb.2010.38 · Cited by 133 · see citing works
Lung dendritic cells at the innate-adaptive immune interface
Condon, T. V., Sawyer, R. T., Fenton, M. J., & Riches, D. W. H. (2011) · Journal of Leukocyte Biology · doi:10.1189/jlb.0311134 · Cited by 132 · see citing works
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BackgroundInfluentialvan Rijt, L. S., Prins, J., Leenen, P. J. M., Thielemans, K., de Vries, V. C., Hoogsteden, H. C., & Lambrecht, B. N. (2002) · Blood · doi:10.1182/blood-2002-03-0673 · Cited by 129 · see citing works
Byrne, S. N., Halliday, G. M., Johnston, L. J., et al. (2001) · Journal of Investigative Dermatology · doi:10.1046/j.0022-202x.2001.01454.x · Cited by 128 · see citing works
Three populations of mouse lymph node dendritic cells with different origins and dynamics
Salomon, B. L. (1997) · Immunology Letters · doi:10.1016/s0165-2478(97)87647-x · Cited by 126 · see citing works
Woltman, A. M., de Fijter, J. W., Zuidwijk, K., Veldhuis‐Vlug, A. G., Bajema, I. M., van der Kooij, S. W., van Ham, V., & van Kooten, C. (2007) · Kidney International · doi:10.1038/sj.ki.5002187 · Cited by 123 · see citing works
Dendritic cells and the replication of HIV-1
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Freeman, C. M., Martínez, F. J., Han, M. K., et al. (2009) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200904-0552oc · Cited by 121 · see citing works
Stumbles, P. A., Strickland, D. H., Pimm, C. L., Proksch, S., Marsh, A. M., McWilliam, A. S., Bosco, A., Tobagus, I. T., Thomas, J. A., Napoli, S., et al. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.1.228 · Cited by 121 · see citing works
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Badalian‐Very, G., Vergilio, J., Degar, B. A., Galindo, C. R., & Rollins, B. J. (2011) · British Journal of Haematology · doi:10.1111/j.1365-2141.2011.08915.x · Cited by 116 · see citing works
“After haematopoietic stem cell transplantation, donor cells efficiently replace recipient classical DCs including those that populate mucosal surfaces (Holt et al, 1994; Iijima et al, 2007; Liu et al, 2007, 2009).”
BackgroundDifferential Response of Respiratory Dendritic Cell Subsets to Influenza Virus Infection
Hao, X., Kim, T. S., & Braciale, T. J. (2008) · Journal of Virology · doi:10.1128/jvi.02367-07 · Cited by 116 · see citing works
“Since RDC are included among the CD45 CD11c cells found in the murine lungs (20), we identified CD45 CD11c cells as the initial step in characterizing their response to influenza virus infection.”
BackgroundThe distribution of immune cells in the uveal tract of the normal eye
McMenamin, P. G. (1997) · Eye · doi:10.1038/eye.1997.49 · Cited by 115 · see citing works
Rugtveit, J., Bakka, A. O., & Brandtzaeg, P. (1997) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.1997.5071404.x · Cited by 129 · see citing works
In vivo maturation and migration of dendritic cells
Flores‐Romo, L. (2001) · Immunology · doi:10.1046/j.1365-2567.2001.01204.x · Cited by 115 · see citing works
Cooke, K. R., & Yanik, G. A. (2004) · Bone Marrow Transplantation · doi:10.1038/sj.bmt.1704629 · Cited by 113 · see citing works
Hammad, H., Lambrecht, B. N., Pochard, P., et al. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.3.1524 · Cited by 112 · see citing works
“This rapid migration of airway DCs is also reflected by their short half-life within the airway mucosa (22).”
BackgroundThe Distinctive Features of Influenza Virus Infection of Dendritic Cells
Bender, A., Albert, M. L., Reddy, A., et al. (1998) · Immunobiology · doi:10.1016/s0171-2985(98)80078-8 · Cited by 111 · see citing works
Antigen Presentation in the Lung
Holt, P. G. (2000) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.162.supplement_3.15tac2 · Cited by 109 · see citing works
Self-citationMaturation and Migration of Cutaneous Dendritic Cells
Hoffman, L. A., Pope, M., & Steinman, R. M. (1995) · Journal of Investigative Dermatology · doi:10.1038/jid.1995.2 · Cited by 111 · see citing works
Lagranderie, M., Nahori, M., Balazuc, A., Kiefer‐Biasizzo, H., Silva, J. R. L. E., Milon, G., Marchal, G., & Vargaftig, B. B. (2003) · Immunology · doi:10.1046/j.1365-2567.2003.01609.x · Cited by 109 · see citing works
Holt, P. G., & Stumbles, P. A. (2000) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2000.105010 · Cited by 106 · see citing works
Self-citationThree Populations of Mouse Lymph Node Dendritic Cells with Different Origins and Dynamics
Salomon, B. L., Cohen, J. L., Masurier, C., & Klatzmann, D. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.160.2.708 · Cited by 100 · see citing works
Bracke, K. R., Cataldo, D. D., Maes, T., Gueders, M. M., Noël, A., Foidart, J., Brusselle, G., & PAUWELS, R. A. (2005) · International Archives of Allergy and Immunology · doi:10.1159/000088439 · Cited by 99 · see citing works
Smed‐Sörensen, A., Chalouni, C. M., Chatterjee, B., Cohn, L. B., Blattmann, P., Nakamura, N., Delamarre, L., & Mellman, I. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002572 · Cited by 99 · see citing works
“DCs reside in the epithelia of the upper respiratory tract, the site of entry for IAV, and are also rapidly mobilized to this site following inhalation of microbial agents [8–9].”
BackgroundChanging Paradigms in Cutaneous Immunology: Adapting with Dendritic Cells
Larregina, A. T., & Falo, L. D. (2005) · Journal of Investigative Dermatology · doi:10.1111/j.1523-1747.2004.23554.x · Cited by 95 · see citing works
Nicod, L. P. (1999) · Respiration · doi:10.1159/000029329 · Cited by 95 · see citing works
Maturation and Migration of Cutaneous Dendritic Cells.
Steinman, R. M., Hoffman, L. A., & Pope, M. (1995) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12315162 · Cited by 93 · see citing works
Osterholzer, J. J., Ames, T. M., Polak, T., Sonstein, J., Moore, B. B., Chensue, S. W., Toews, G. B., & Curtis, J. L. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.2.874 · Cited by 89 · see citing works
“Within unperturbed lungs, immature DC (iDC) reside in airway epithelium, alveolar septae, and the connective tissue surrounding pulmonary vessels (4), but are rarely found within the alveolar spaces.”
BackgroundAngéli, V., Hammad, H., Staels, B., Capron, M., Lambrecht, B. N., & Trottein, F. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.10.5295 · Cited by 90 · see citing works
“We next studied the possibility that PPAR activation could also play a role in the spontaneous migration of intramucosal DCs (59) after intratracheal injection of FITC-OVA.”
Background
- Authors
- Holt, P. G., Haining, S., Nelson, D. J., & Sedgwick, J. D.
- Affiliations
- The Kids Research Institute Australia (AU)
- Centenary Institute (AU)
- ORCID
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1994-07-01
- Volume
- 153
- Issue
- 1
- Pages
- 256-261
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1675056235
- Cited by
- 347
- References
- 0
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 6 · 2023: 6 · 2022: 2 · 2020: 5 · 2019: 1 · 2018: 3 · 2017: 11 · 2016: 3 · 2015: 6 · 2014: 7 · 2013: 5 · 2012: 14
- FWCI
- 6.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Immunology (publishedVersion)
- PubMed (publishedVersion)
- UWA Profiles and Research Repository (UWA) (submittedVersion)
- Funders
- Wellcome Trust
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- airway epithelium, radiation chimeras, Langerhans cells, mucosal immunity, X-ray irradiation
- MeSH terms
- Animals, Histocompatibility Antigens Class II, Dendritic Cells, Dexamethasone, Epithelial Cells, Langerhans Cells, Lung, Radiation Chimera, Trachea, X-Rays, Rats
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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