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REGULATION OF THE MOVEMENT OF SOLUTES ACROSS TIGHT JUNCTIONS
Abstract
▪ Abstract The intercellular tight junction is the rate-limiting barrier in the paracellular pathway for permeation by ions and larger solutes. A variety of widely used electrical and flux approaches are used in the analyses of solute permeation through this pathway; however, each has limitations in practice. It is now clear that solute permeation across tight junctions is dynamically regulated by intracellular events with a common effector mechanism apparently tied to the cytoskeleton. These pathways, which regulate tight junction solute permeability, are targets that produce epithelial barrier dysfunction in a variety of disease states. However, regulation of solute permeation across the junctional barrier may also represent a potential means to improve bioavailability of orally administered bioactive solutes.
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Cited by
Itoh, M., Furuse, M., Morita, K., Kubota, K., Saitou, M., & Tsukita, S. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.147.6.1351 · Cited by 1,151
Kelly, J. R., Kennedy, P. J., Cryan, J. F., Dinan, T. G., Clarke, G., & Hyland, N. P. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00392 · Cited by 1,110
The blood-brain barrier: an engineering perspective
Wong, A. D., Ye, M., Levy, A. F., Rothstein, J. D., Bergles, D. E., & Searson, P. C. (2013) · Frontiers in Neuroengineering · doi:10.3389/fneng.2013.00007 · Cited by 662
Skin hydration: A review on its molecular mechanisms
Verdier‐Sévrain, S., & Bonté, F. (2007) · Journal of Cosmetic Dermatology · doi:10.1111/j.1473-2165.2007.00300.x · Cited by 605
Van Itallie, C., Rahner, C., & Anderson, J. M. (2001) · Journal of Clinical Investigation · doi:10.1172/jci12464 · Cited by 601
Metadata
- Authors
- Madara, J. L.
- Venue
- Annual Review of Physiology
- Publisher
- Annual Reviews
- Published
- 1998-10
- Volume
- 60
- Issue
- 1
- Pages
- 143-159
- ISSN
- 0066-4278 (ISSN-L)
- 1545-1585
- OpenAlex
- W2118762743
- Cited by
- 523
- References
- 0
- FWCI
- 2.85
- Type
- journal article
- Language
- en
- Open access
- closed
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- Madara, J. L. (1998). REGULATION OF THE MOVEMENT OF SOLUTES ACROSS TIGHT JUNCTIONS. Annual Review of Physiology. https://doi.org/10.1146/annurev.physiol.60.1.143
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
