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Cited by 601

The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.

Regulated expression of claudin-4 decreases paracellular conductance through a selective decrease in sodium permeability

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Van Itallie, Christina, Rahner, Christoph, Anderson, James Melvin·2001·Journal of Clinical Investigation
DOI 10.1172/jci12464
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Abstract

Tight junctions regulate paracellular conductance and ionic selectivity. These properties vary among epithelia but the molecular basis of this variation remains unknown. To test whether members of the claudin family of tight junction proteins influence paracellular ionic selectivity, we expressed human claudin-4 in cultured MDCK cells using an inducible promoter. Overexpression increased the complexity of tight junction strands visible by freeze-fracture microscopy without affecting the levels of claudin-1, -2, or -3, occludin, or ZO-1. A decrease in conductance correlated directly with the kinetics of claudin-4 induction. Dilution potentials revealed that the decrease in paracellular conductance resulted from a selective decrease in Na(+) permeability without a significant effect on Cl(-) permeability. Flux for an uncharged solute, mannitol, and the rank order of permeabilities for the alkali metal cations were unchanged. A paracellular site for these effects was supported by the lack of apical/basal directionality of the dilution potentials, the linearity of current-voltage relationships, and the lack of influence of inhibitors of major transcellular transporters. These results provide, to our knowledge, the first direct demonstration of the ability of a claudin to influence paracellular ion selectivity and support a role for the claudins in creating selective channels through the tight-junction barrier.

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Metadata

Authors
Van Itallie, C., Rahner, C., & Anderson, J. M.
Venue
Journal of Clinical Investigation
Publisher
American Society for Clinical Investigation
Published
2001-05-15
Volume
107
Issue
10
Pages
1319-1327
ISSN
0021-9738 (ISSN-L)
DOI
10.1172/jci12464
OpenAlex
W2128616002
Cited by
601
References
34
FWCI
14.41
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Regulated expression of claudin-4 decreases paracellular conductance through a selective decrease in sodium permeability. https://app.cochat.ai/papers/10.1172/jci12464
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Van Itallie, C., Rahner, C., & Anderson, J. M. (2001). Regulated expression of claudin-4 decreases paracellular conductance through a selective decrease in sodium permeability. Journal of Clinical Investigation. https://doi.org/10.1172/jci12464

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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.