The DOI matches its Crossref record; 101 of the 101 references it cites were found in a registry or an index.
ROLE OF TIGHT JUNCTIONS IN ESTABLISHING AND MAINTAINING CELL POLARITY
Abstract
▪ Abstract The tight junction (TJ) is not randomly located on the cell membrane, but occupies a precise position at the outermost edge of the intercellular space and, therefore, is itself considered a polarized structure. This article reviews the most common experimental approaches for studying this relationship. We then discuss three main topics. (a) The mechanisms of polarization that operate regardless of the presence of TJs: We explore a variety of polarization mechanisms that operate at stages of the cell cycle in which TJs may be already established. (b) TJs and polarity as partners in highly dynamic processes: Polarity and TJs are steady state situations that may be drastically changed by a variety of signaling events. (c) Polarized distribution of membrane molecules that depend on TJs: This refers to molecules (mainly lipids) whose polarized distribution, although not the direct result of TJs, depends on these structures to maintain such distribution.
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Citations
Cites
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Self-citationPolarized monolayers formed by epithelial cells on a permeable and translucent support
Cereijido, M., Robbins, E., Dolan, W., Rotunno, C., & Sabatini, D. (1978) · The Journal of cell biology · doi:10.1083/jcb.77.3.853 · Cited by 868
Self-citationGumbiner, B., Stevenson, B., & Grimaldi, A. (1988) · The Journal of cell biology · doi:10.1083/jcb.107.4.1575 · Cited by 799
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BIOLOGICAL PROPERTIES AND CLASSIFICATION OF THE CAULOBACTER GROUP
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The acetylcholine sensitivity of frog muscle fibres after complete or partial denervation
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Cited by
Itoh, M., Furuse, M., Morita, K., Kubota, K., Saitou, M., & Tsukita, S. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.147.6.1351 · Cited by 1,151
Physiology and function of the tight junction
Anderson, J. M., & Van Itallie, C. M. (2009) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a002584 · Cited by 1,059
A mammalian PAR-3–PAR-6 complex implicated in Cdc42/Rac1 and aPKC signalling and cell polarity
Lin, D., Edwards, A. S., Fawcett, J. P., Mbamalu, G., Scott, J. D., & Pawson, T. (2000) · Nature Cell Biology · doi:10.1038/35019582 · Cited by 743
Luissint, A.-C., Artus, C., Glacial, F., Ganeshamoorthy, K., & Couraud, P.-O. (2012) · Fluids and Barriers of the CNS · doi:10.1186/2045-8118-9-23 · Cited by 654
“TJs constitute the most apical intercellular junctional complex in polarized epithelium and endothelium, with three key biological functions: a barrier to paracellular diffusion of bloodborne polar substances [4], a fence preventing the lateral diffusion of lipids and integral membrane proteins, thus maintaining cell…”
Luissint, A.-C., Parkos, C. A., & Nusrat, A. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.07.008 · Cited by 555
Metadata
- Authors
- Cereijido, M., Valdés, J., Shoshani, L., & Contreras, R. G.
- Venue
- Annual Review of Physiology
- Publisher
- Annual Reviews
- Published
- 1998-10
- Volume
- 60
- Issue
- 1
- Pages
- 161-177
- ISSN
- 0066-4278 (ISSN-L)
- 1545-1585
- OpenAlex
- W2114895224
- Cited by
- 256
- References
- 101
- FWCI
- 1.23
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: ROLE OF TIGHT JUNCTIONS IN ESTABLISHING AND MAINTAINING CELL POLARITY. https://app.cochat.ai/papers/10.1146/annurev.physiol.60.1.161
- The paper
- Cereijido, M., Valdés, J., Shoshani, L., & Contreras, R. G. (1998). ROLE OF TIGHT JUNCTIONS IN ESTABLISHING AND MAINTAINING CELL POLARITY. Annual Review of Physiology. https://doi.org/10.1146/annurev.physiol.60.1.161
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
