The DOI matches its Crossref record; 192 of the 192 references it cites were found in a registry or an index.
Inflammation and the Intestinal Barrier: Leukocyte–Epithelial Cell Interactions, Cell Junction Remodeling, and Mucosal Repair
Open accessAbstract
The intestinal tract is lined by a single layer of columnar epithelial cells that forms a dynamic, permeable barrier allowing for selective absorption of nutrients, while restricting access to pathogens and food-borne antigens. Precise regulation of epithelial barrier function is therefore required for maintaining mucosal homeostasis and depends, in part, on barrier-forming elements within the epithelium and a balance between pro- and anti-inflammatory factors in the mucosa. Pathologic states, such as inflammatory bowel disease, are associated with a leaky epithelial barrier, resulting in excessive exposure to microbial antigens, recruitment of leukocytes, release of soluble mediators, and ultimately mucosal damage. An inflammatory microenvironment affects epithelial barrier properties and mucosal homeostasis by altering the structure and function of epithelial intercellular junctions through direct and indirect mechanisms. We review our current understanding of complex interactions between the intestinal epithelium and immune cells, with a focus on pathologic mucosal inflammation and mechanisms of epithelial repair. We discuss leukocyte–epithelial interactions, as well as inflammatory mediators that affect the epithelial barrier and mucosal repair. Increased knowledge of communication networks between the epithelium and immune system will lead to tissue-specific strategies for treating pathologic intestinal inflammation.
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Garcia‐Hernandez, V., Quiros, M., & Nusrat, A. (2017) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13360 · Cited by 445
Self-citationGut Microbial Dysbiosis in the Pathogenesis of Gastrointestinal Dysmotility and Metabolic Disorders
Singh, R., Zogg, H., Wei, L., Bartlett, A., Ghoshal, U. C., Rajender, S., & Ro, S. (2021) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm20149 · Cited by 259
Zhang, C., Yan, J., Xiao, Y., Shen, Y., Wang, J., Ge, W., & Chen, Y. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18010157 · Cited by 76
Yin, M., Yan, X., Weng, W., Yang, Y., Gao, R., Liu, M., Pan, C., Zhu, Q., Li, H., Wei, Q., et al. (2018) · Cellular Physiology and Biochemistry · doi:10.1159/000487027 · Cited by 58
Yin, J., Zhao, Z., Huang, J., Xiao, Y., Rehmutulla, M., Zhang, B., Zhang, Z., Xiang, M., Tong, Q., & Zhang, Y. (2023) · Cell Discovery · doi:10.1038/s41421-023-00578-4 · Cited by 24
Metadata
- Authors
- Luissint, A.-C., Parkos, C. A., & Nusrat, A.
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 2016-10
- Volume
- 151
- Issue
- 4
- Pages
- 616-632
- ISSN
- 0016-5085 (ISSN-L)
- OpenAlex
- W2486949243
- Cited by
- 555
- References
- 192
- FWCI
- 21.28
- Type
- journal article
- Language
- en
- Open access
- green
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- Luissint, A.-C., Parkos, C. A., & Nusrat, A. (2016). Inflammation and the Intestinal Barrier: Leukocyte–Epithelial Cell Interactions, Cell Junction Remodeling, and Mucosal Repair. Gastroenterology. https://doi.org/10.1053/j.gastro.2016.07.008
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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