The DOI matches its Crossref record; 116 of the 116 references it cites were found in a registry or an index.
Chloride Secretion by the Intestinal Epithelium: Molecular Basis and Regulatory Aspects
Abstract
▪ Abstract Chloride secretion is the major determinant of mucosal hydration thoughout the gastrointestinal tract, and chloride transport is also pivotal in the regulation of fluid secretion by organs that drain into the intestine. Moreover, there are pathological consequences if chloride secretion is either reduced or increased such as in cystic fibrosis and secretory diarrhea, respectively. With the molecular cloning of many of the proteins and regulatory factors that make up the chloride secretory mechanism, there have been significant advances in our understanding of this process at the cellular level. Similarly, emerging data have clarified the intercellular relationships that govern the extent of chloride secretion. The goal of our article is to review this area of investigation, with an emphasis on recent developments and their implications for the physiology and pathophysiology of chloride transport.
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Cites
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Cited by
Electrolyte transport in the mammalian colon: mechanisms and implications for disease
Kunzelmann, K., & Mall, M. (2002) · Physiological Reviews · doi:10.1152/physrev.00026.2001 · Cited by 655
Chloride channels as drug targets
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Camilleri, M., Bharucha, A. E., Ueno, R., Burton, D., Thomforde, G. M., Baxter, K., McKinzie, S., & Zinsmeister, A. R. (2006) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00264.2005 · Cited by 253
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Tight junctions as targets and effectors of mucosal immune homeostasis
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Metadata
- Authors
- Barrett, K. E., & Keely, S. J.
- Venue
- Annual Review of Physiology
- Publisher
- Annual Reviews
- Published
- 2000-03
- Volume
- 62
- Issue
- 1
- Pages
- 535-572
- ISSN
- 0066-4278 (ISSN-L)
- 1545-1585
- OpenAlex
- W2170372540
- Cited by
- 489
- References
- 116
- FWCI
- 0.97
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Chloride Secretion by the Intestinal Epithelium: Molecular Basis and Regulatory Aspects. https://app.cochat.ai/papers/10.1146/annurev.physiol.62.1.535
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- Barrett, K. E., & Keely, S. J. (2000). Chloride Secretion by the Intestinal Epithelium: Molecular Basis and Regulatory Aspects. Annual Review of Physiology. https://doi.org/10.1146/annurev.physiol.62.1.535
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
