The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Molecular Aspects of Renal Anionic Drug Transport
Abstract
▪ Abstract Multiple organic anion transporters in the proximal tubule of the kidney are involved in the secretion of drugs, toxic compounds, and their metabolites. Many of these compounds are potentially hazardous on accumulation, and it is therefore not surprising that the proximal tubule is also an important target for toxicity. In the past few years, considerable progress has been made in the cloning of these transporters and their functional characterization following heterologous expression. Members of the organic anion transporter (OAT), organic anion transporting polypeptide (OATP), multidrug resistance protein (MRP), sodium-phosphate transporter (NPT), and peptide transporter (PEPT) families have been identified in the kidney. In this review, we summarize our current knowledge on their localization, molecular and functional characteristics, and substrate and inhibitor specificity. A major challenge for the future will be to understand how these transporters work in concert to accomplish the renal secretion of specific anionic substrates.
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Cites
Overexpression of a Transporter Gene in a Multidrug-Resistant Human Lung Cancer Cell Line
Cole, S. P. C., Bhardwaj, G., Gerlach, J. H., Mackie, J. E., Grant, C. E., Almquist, K. C., Stewart, A. J., Kurz, E. U., Duncan, A. M. V., & Deeley, R. G. (1992) · Science · doi:10.1126/science.1360704 · Cited by 3,037
Cited by
Ochratoxin A: An overview on toxicity and carcinogenicity in animals and humans
Pfohl‐Leszkowicz, A., & Manderville, R. A. (2007) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200600137 · Cited by 1,017
Impact of Drug Transporter Studies on Drug Discovery and Development
Mizuno, N., Niwa, T., Yotsumoto, Y., & Sugiyama, Y. (2003) · Pharmacological Reviews · doi:10.1124/pr.55.3.1 · Cited by 490
Matherly, L. H., & Goldman, I. D. (2003) · Vitamins & Hormones · doi:10.1016/s0083-6729(03)01012-4 · Cited by 386
RUSSEL, F., KOENDERINK, J., & MASEREEUW, R. (2008) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2008.01.006 · Cited by 383
Self-citationRizwan, A. N., & Burckhardt, G. (2007) · Pharmaceutical Research · doi:10.1007/s11095-006-9181-4 · Cited by 275
Metadata
- Authors
- Russel, F. G. M., Masereeuw, R., & van Aubel, R. A. M. H.
- Venue
- Annual Review of Physiology
- Publisher
- Annual Reviews
- Published
- 2002-03
- Volume
- 64
- Issue
- 1
- Pages
- 563-594
- ISSN
- 0066-4278 (ISSN-L)
- 1545-1585
- OpenAlex
- W2165860016
- Cited by
- 221
- References
- 1
- FWCI
- 1.25
- Type
- journal article
- Language
- en
- Open access
- closed
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- Russel, F. G. M., Masereeuw, R., & van Aubel, R. A. M. H. (2002). Molecular Aspects of Renal Anionic Drug Transport. Annual Review of Physiology. https://doi.org/10.1146/annurev.physiol.64.081501.155913
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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