The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Regulation of TRP Channels via Lipid Second Messengers
Abstract
▪ Abstract In Drosophila photoreceptors, the light-sensitive current is mediated downstream of phospholipase C by TRP (transient receptor potential) channels. Recent evidence suggests that Drosophila TRP channels are activated by diacylglycerol (DAG) or its metabolites (polyunsaturated fatty acids), possibly in combination with the reduction in phosphatidyl inositol 4,5 bisphosphate (PIP 2). Consistent with this view, diacylglycerol kinase is identified as a key enzyme required for response termination. Signaling is critically dependent upon efficient PIP 2 synthesis; mutants of this pathway in combination with genetically targeted PIP 2 reporters provide unique insights into the kinetics and regulation of PIP 2 turnover. Recent evidence indicates that a growing number of mammalian TRP homologues are also regulated by lipid messengers, including DAG, arachidonic acid, and PIP 2.
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Cites
PIP2and Proteins: Interactions, Organization, and Information Flow
McLaughlin, S., Wang, J., Gambhir, A., & Murray, D. (2002) · Annual Review of Biophysics and Biomolecular Structure · doi:10.1146/annurev.biophys.31.082901.134259 · Cited by 837
Cited by
TRP channels as cellular sensors
Clapham, D. E. (2003) · Nature · doi:10.1038/nature02196 · Cited by 2,779
Phosphoinositides: Tiny Lipids With Giant Impact on Cell Regulation
Balla, T. (2013) · Physiological Reviews · doi:10.1152/physrev.00028.2012 · Cited by 1,638
Induction of photosensitivity by heterologous expression of melanopsin
Qiu, X., Kumbalasiri, T., Carlson, S. M., Wong, K. Y., Krishna, V., Provencio, I., & Berson, D. M. (2005) · Nature · doi:10.1038/nature03345 · Cited by 431
Lucas, P., Ukhanov, K., Leinders-Zufall, T., & Zufall, F. (2003) · Neuron · doi:10.1016/s0896-6273(03)00675-5 · Cited by 323
Fly photoreceptors demonstrate energy-information trade-offs in neural coding
Niven, J. E., Anderson, J. C., & Laughlin, S. B. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050116 · Cited by 272
Metadata
- Authors
- Hardie, R. C.
- Venue
- Annual Review of Physiology
- Publisher
- Annual Reviews
- Published
- 2003-03
- Volume
- 65
- Issue
- 1
- Pages
- 735-759
- ISSN
- 0066-4278 (ISSN-L)
- 1545-1585
- OpenAlex
- W2102305820
- Cited by
- 204
- References
- 1
- FWCI
- 1.80
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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