The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Localization of Voltage-Gated Ion Channels IN Mammalian Brain
Abstract
▪ Abstract The intrinsic electrical properties of neurons are shaped in large part by the action of voltage-gated ion channels. Molecular cloning studies have revealed a large family of ion channel genes, many of which are expressed in mammalian brain. Much recent effort has focused on determining the contribution of the protein products of these genes to neuronal function. This requires knowledge of the abundance and distribution of the constituent subunits of the channels in specific mammalian central neurons. Here we review progress made in recent studies aimed at localizing specific ion channel subunits using in situ hybridization and immunohistochemistry. We then discuss the implications of these results in terms of neuronal physiology and neuronal mechanisms underlying the observed patterns of expression.
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Citations
Cites
Structure and Regulation of Voltage-Gated Ca 2+ Channels
Catterall, W. A. (2000) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.16.1.521 · Cited by 2,344
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Sodium channel Na v 1.6 is localized at nodes of Ranvier, dendrites, and synapses
Caldwell, J. H., Schaller, K. L., Lasher, R. S., Peles, E., & Levinson, S. R. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.090034797 · Cited by 649
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KChIPs and Kv4 α Subunits as Integral Components of A-Type Potassium Channels in Mammalian Brain
Rhodes, K. J., Carroll, K. I., Sung, M. A., Doliveira, L. C., Monaghan, M. M., Burke, S. L., Strassle, B. W., Buchwalder, L., Menegola, M., Cao, J., et al. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.0776-04.2004 · Cited by 243
Self-citationGasparini, S., Kasyanov, A. M., Pietrobon, D., Voronin, L. L., & Cherubini, E. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-22-08715.2001 · Cited by 114
Cited by
Irani, S. R., Alexander, S., Waters, P., Kleopa, K. A., Pettingill, P., Zuliani, L., Peles, E., Buckley, C., Lang, B., & Vincent, A. (2010) · Brain · doi:10.1093/brain/awq213 · Cited by 1,359
Mechanisms of action of currently used antiseizure drugs
Sills, G. J., & Rogawski, M. A. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.107966 · Cited by 489
Localization and Targeting of Voltage-Dependent Ion Channels in Mammalian Central Neurons
Vacher, H., Mohapatra, D. P., & Trimmer, J. S. (2008) · Physiological Reviews · doi:10.1152/physrev.00002.2008 · Cited by 488
Self-citationThe roles of sodium channels in nociception: Implications for mechanisms of pain
Cummins, T. R., Sheets, P. L., & Waxman, S. G. (2007) · Pain · doi:10.1016/j.pain.2007.07.026 · Cited by 485
The distribution and targeting of neuronal voltage-gated ion channels
Lai, H. C., & Jan, L. Y. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1938 · Cited by 468
Metadata
- Authors
- Trimmer, J. S., & Rhodes, K. J.
- Venue
- Annual Review of Physiology
- Publisher
- Annual Reviews
- Published
- 2004-03-01
- Volume
- 66
- Issue
- 1
- Pages
- 477-519
- ISSN
- 0066-4278 (ISSN-L)
- 1545-1585
- OpenAlex
- W2151312529
- Cited by
- 442
- References
- 7
- FWCI
- 1.84
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
