The DOI matches its Crossref record; 118 of the 118 references it cites were found in a registry or an index.
Epithelial-Mesenchymal Interactions in the Developing Lung
Abstract
Classical experiments in embryology have shown that normal growth, morphogenetic patterning, and cellular differentiation in the developing lung depend on interactive signaling between the endodermal epithelium and mesenchyme derived from splanchnic mesoderm. These interactions are mediated by a myriad of diffusible factors that are precisely regulated in their temporal and spatial expression. In this review we first describe factors regulating formation of the embryonic foregut. We then discuss the experiments demonstrating the importance of tissue interactions in lung patterning and differentiation. Finally, we detail the roles that a few key signaling systems-fibroblast growth factors and their receptors, sonic hedgehog and Gli genes, Wnt genes and beta-catenin, and BMP4-play as mediators of epithelial-mesenchymal interactions in the developing lung.
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In the citing paper
“During the early developmental stages, epithelial-mesenchymal interactions (EMIs) trigger the development of various tissues and organs through specific signaling pathways and transcription factors.”
From Reprogramming of three-dimensional microenvironments for in vitro hair follicle induction (2022) · cites this paper as [3]
In the citing paper
“For example, EMIs drive stomach specification (1), duct patterning of the kidney (2) and lung (3), and bud formation of the lacrimal gland (4) and teeth (5).”
From Reprogramming of three-dimensional microenvironments for in vitro hair follicle induction (2022) · cites this paper as [3]
Citations
Cites
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Cited by
Sorted by citations
Role of Epithelial Cells in Idiopathic Pulmonary Fibrosis: From Innocent Targets to Serial Killers
Selman, M., & Pardo, A. (2006) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200601-003tk · Cited by 528
Transcriptional Control of Lung Morphogenesis
Maeda, Y., Davé, V., & Whitsett, J. A. (2007) · Physiological Reviews · doi:10.1152/physrev.00028.2006 · Cited by 471
Epithelial-Mesenchymal Interactions in Pulmonary Fibrosis
Chapman, H. A. (2011) · Annual Review of Physiology · doi:10.1146/annurev-physiol-012110-142225 · Cited by 418
LUNG VASCULAR DEVELOPMENT: Implications for the Pathogenesis of Bronchopulmonary Dysplasia
Stenmark, K. R., & Abman, S. H. (2004) · Annual Review of Physiology · doi:10.1146/annurev.physiol.67.040403.102229 · Cited by 378
Regulation of the Pulmonary Circulation in the Fetus and Newborn
Gao, Y., & Raj, J. U. (2010) · Physiological Reviews · doi:10.1152/physrev.00032.2009 · Cited by 357
Metadata
- Authors
- Shannon, J. M., & Hyatt, B. A.
- Affiliations
- Cincinnati Children's Hospital Medical Center (US)
- Venue
- Annual Review of Physiology
- Publisher
- Annual Reviews
- Published
- 2004-03-01
- Volume
- 66
- Issue
- 1
- Pages
- 625-645
- ISSN
- 0066-4278 (ISSN-L)
- 1545-1585
- OpenAlex
- W2137075665
- Semantic Scholar
- 44ca64a235304c55d005355606216882e6b05a45
- Cited by
- 321
- References
- 118
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 4 · 2023: 7 · 2022: 6 · 2021: 11 · 2020: 8 · 2019: 13 · 2018: 4 · 2017: 13 · 2016: 10 · 2015: 17 · 2014: 14 · 2013: 14 · 2012: 23
- FWCI
- 2.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Physiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01HL071898, P50-HL56387, P50HL056387)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Neonatal Respiratory Health Research
- Health Sciences › Medicine › Oncology › Renal and related cancers
- Keywords
- epithelial-mesenchymal interactions, lung development, lung morphogenesis, lung differentiation, fibroblast growth factor, Sonic hedgehog, Wnt signaling, β-catenin, BMP4, splanchnic mesoderm, endodermal epithelium, signaling molecules
- MeSH terms
- Animals, Embryo, Mammalian, Endoderm, Epithelium, Embryonic and Fetal Development, Humans, Lung, Mesoderm
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