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Epithelial-Mesenchymal Interactions in the Developing Lung
Abstract
Classical experiments in embryology have shown that normal growth, morphogenetic patterning, and cellular differentiation in the developing lung depend on interactive signaling between the endodermal epithelium and mesenchyme derived from splanchnic mesoderm. These interactions are mediated by a myriad of diffusible factors that are precisely regulated in their temporal and spatial expression. In this review we first describe factors regulating formation of the embryonic foregut. We then discuss the experiments demonstrating the importance of tissue interactions in lung patterning and differentiation. Finally, we detail the roles that a few key signaling systems-fibroblast growth factors and their receptors, sonic hedgehog and Gli genes, Wnt genes and beta-catenin, and BMP4-play as mediators of epithelial-mesenchymal interactions in the developing lung.
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“During the early developmental stages, epithelial-mesenchymal interactions (EMIs) trigger the development of various tissues and organs through specific signaling pathways and transcription factors.”
From Reprogramming of three-dimensional microenvironments for in vitro hair follicle induction (2022) · cites this paper as [3]
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“For example, EMIs drive stomach specification (1), duct patterning of the kidney (2) and lung (3), and bud formation of the lacrimal gland (4) and teeth (5).”
From Reprogramming of three-dimensional microenvironments for in vitro hair follicle induction (2022) · cites this paper as [3]
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Cites
Hedgehog signaling in animal development: paradigms and principlesPreprint
Ingham, P. W., & McMahon, A. P. (2001) · Genes & Development · doi:10.1101/gad.938601 · Cited by 3,025
MECHANISMS OF WNT SIGNALING IN DEVELOPMENT
Wodarz, A., & Nusse, R. (1998) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.14.1.59 · Cited by 2,030
Bone morphogenetic proteins: multifunctional regulators of vertebrate development.Preprint
Hogan, B. L. M. (1996) · Genes & Development · doi:10.1101/gad.10.13.1580 · Cited by 1,964
Fgf10 is essential for limb and lung formation
Sekine, K., Ohuchi, H., Fujiwara, M., Yamasaki, M., Yoshizawa, T., Sato, T., Yagishita, N., Matsui, D., Koga, Y., Itoh, N., et al. (1999) · Nature Genetics · doi:10.1038/5096 · Cited by 1,283
Structural Characterization and Biological Functions of Fibroblast Growth Factor
Gospodarowicz, D., Ferrara, N., Schweigerer, L., & Neufeld, G. (1987) · Endocrine Reviews · doi:10.1210/edrv-8-2-95 · Cited by 1,273
Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis.Preprint
Molkentin, J. D., Lin, Q., Duncan, S. A., & Olson, E. N. (1997) · Genes & Development · doi:10.1101/gad.11.8.1061 · Cited by 1,137
GATA4 transcription factor is required for ventral morphogenesis and heart tube formation.Preprint
Kuo, C. T., Morrisey, E. E., Anandappa, R. T., Sigrist, K. S., Lu, M. M., Parmacek, M. S., Soudais, C., & Leiden, J. M. (1997) · Genes & Development · doi:10.1101/gad.11.8.1048 · Cited by 1,029
Fibroblast Growth Factor 10 (FGF10) and branching morphogenesis in the embryonic mouse lung
Bellusci, S., Grindley, J. C., Emoto, H., Itoh, N., & Hogan, B. L. M. (1997) · Development · doi:10.1242/dev.124.23.4867 · Cited by 1,006
Min, H.-S., Danilenko, D., Scully, S., Bolon, B., Ring, B., Tarpley, J., Derose, M., & Simonet, W. (1998) · Genes & Development · doi:10.1101/gad.12.20.3156 · Cited by 928
Dual Roles for Patched in Sequestering and Transducing Hedgehog
Chen, Y., & Struhl, G. (1996) · Cell · doi:10.1016/s0092-8674(00)81374-4 · Cited by 902
Research works printed but not linked: 7
- Crapo JD, 1982, Am. Rev. Respir. Dis., 125, 332
- Dameron F, 1961, C. R. Acad. Sci., 262, 1642
- Sampaolo G, 1959, C. R. Assoc. Anat., 45, 707
- Lawson KA, 1972, J. Embryol. Exp. Morphol., 27, 497
- Lawson KA, 1974, J. Embryol. Exp. Morphol., 32, 469
- Adamson I, 1984, Am. Rev. Respir. Dis., 129, 130
- 10.1097/00000441-199812000-00003 · DOI
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Self-citation
Metadata
- Authors
- Shannon, J. M., & Hyatt, B. A.
- Affiliations
- Cincinnati Children's Hospital Medical Center (US)
- Venue
- Annual Review of Physiology
- Publisher
- Annual Reviews
- Published
- 2004-03-01
- Volume
- 66
- Issue
- 1
- Pages
- 625-645
- ISSN
- 0066-4278 (ISSN-L)
- 1545-1585
- OpenAlex
- W2137075665
- Semantic Scholar
- 44ca64a235304c55d005355606216882e6b05a45
- Cited by
- 321
- References
- 118
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 4 · 2023: 7 · 2022: 6 · 2021: 11 · 2020: 8 · 2019: 13 · 2018: 4 · 2017: 13 · 2016: 10 · 2015: 17 · 2014: 14 · 2013: 14 · 2012: 23
- FWCI
- 2.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Physiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01HL071898, P50-HL56387, P50HL056387)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Neonatal Respiratory Health Research
- Health Sciences › Medicine › Oncology › Renal and related cancers
- Keywords
- epithelial-mesenchymal interactions, lung development, lung morphogenesis, lung differentiation, fibroblast growth factor, Sonic hedgehog, Wnt signaling, β-catenin, BMP4, splanchnic mesoderm, endodermal epithelium, signaling molecules
- MeSH terms
- Animals, Embryo, Mammalian, Endoderm, Epithelium, Embryonic and Fetal Development, Humans, Lung, Mesoderm
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