The DOI matches its Crossref record; 85 of the 85 references it cites were found in a registry or an index.
Regulation of Mammalian Ciliary Beating
Abstract
Recent advances in our understanding of the structure-function relationship of motile cilia with the 9 + 2 microtubular arrangement have helped explain some of the mechanisms of ciliary beat regulation by intracellular second messengers. These second messengers include cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) as well as calcium and pH. cAMP activates protein kinase A (PKA), which is localized to the axoneme. The cAMP-dependent phosphorylation of PKA's main target, originally described as p29 in Paramecium, seems to increase ciliary beat frequency (CBF) directly. The mechanism by which cGMP increases CBF is less well defined but involves protein kinase G and possibly PKA. Protein kinase C inhibits ciliary beating. The regulation mechanisms of CBF by calcium remain somewhat controversial, favoring an immediate, direct action of calcium on ciliary beating and a second cyclic nucleotide–dependent phase. Finally, intracellular pH likely affects CBF through direct influences on dynein arms.
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Cited by
When cilia go bad: cilia defects and ciliopathies
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Overview of Structure and Function of Mammalian Cilia
Satir, P., & Christensen, S. T. (2007) · Annual Review of Physiology · doi:10.1146/annurev.physiol.69.040705.141236 · Cited by 1,142
Mechanisms of sperm chemotaxis
Kaupp, U. B., Kashikar, N. D., & Weyand, I. (2008) · Annual Review of Physiology · doi:10.1146/annurev.physiol.70.113006.100654 · Cited by 284
Masyuk, A. I., Gradilone, S. A., Banales, J. M., Huang, B. Q., Masyuk, T. V., Lee, S.-O., Splinter, P. L., Stroope, A. J., & LaRusso, N. F. (2008) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.90265.2008 · Cited by 170
Currie, K. W., & Pearson, B. J. (2013) · Development · doi:10.1242/dev.098590 · Cited by 131
Metadata
- Authors
- Salathe, M.
- Venue
- Annual Review of Physiology
- Publisher
- Annual Reviews
- Published
- 2007-03-01
- Volume
- 69
- Issue
- 1
- Pages
- 401-422
- ISSN
- 0066-4278 (ISSN-L)
- 1545-1585
- OpenAlex
- W2150028083
- Cited by
- 401
- References
- 85
- FWCI
- 1.33
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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