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The Phenomenon of Reoxygenation and Its Implications for Fractionated Radiotherapy
Abstract
The radiobiological oxygen effect is critical in radiotherapy, as all experimental tumors that have been tested contain large proportions (approximately 1–50%) of severely hypoxic cells, and many human tumors are partially hypoxic on histopathological grounds. In designing fractionated dose regimens, it is essential to recognize the special importance of the reoxygenation of preferentially surviving hypoxic cells. Most animal tumors have been shown to reoxygenate rapidly enough that the hypoxic fraction is restored to the preirradiated level within approximately 24 hours. Different tumors may reoxygenate at different rates. It is presently impossible to identify the mechanism(s) responsible for reoxygenation.
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Cited by
Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors
Moeller, B. J., Cao, Y., Li, C. Y., & Dewhirst, M. W. (2004) · Cancer Cell · doi:10.1016/s1535-6108(04)00115-1 · Cited by 996
Teicher, B. A. (1994) · Cancer and Metastasis Reviews · doi:10.1007/bf00689633 · Cited by 563
Tumor hypoxia: its impact on cancer therapy
Moulder, J. E., & Rockwell, S. (1987) · Cancer and Metastasis Reviews · doi:10.1007/bf00055376 · Cited by 414
Microenvironment-induced cancer metastasis
Rofstad, E. K. (2000) · International Journal of Radiation Biology · doi:10.1080/095530000138259 · Cited by 329
Hypoxia Increases Androgen Receptor Activity in Prostate Cancer Cells
Park, S.-Y., Kim, Y.-J., Gao, A. C., Mohler, J. L., Onate, S. A., Hidalgo, A. A., Ip, C., Park, E.-M., Yoon, S. Y., & Park, Y.-M. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-1341 · Cited by 81
Metadata
- Authors
- Kallman, R. F.
- Venue
- Radiology
- Published
- 1972-10
- Volume
- 105
- Issue
- 1
- Pages
- 135-142
- ISSN
- 0033-8419 (ISSN-L)
- 1527-1315
- OpenAlex
- W2031307716
- Cited by
- 294
- References
- 0
- FWCI
- 4.72
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kallman, R. F. (1972). The Phenomenon of Reoxygenation and Its Implications for Fractionated Radiotherapy. Radiology. https://doi.org/10.1148/105.1.135
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