The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Chronic Obstructive Pulmonary Disease Exacerbations in the COPDGene Study: Associated Radiologic Phenotypes
Open accessAbstract
PURPOSE: To test the hypothesis-given the increasing emphasis on quantitative computed tomographic (CT) phenotypes of chronic obstructive pulmonary disease (COPD)-that a relationship exists between COPD exacerbation frequency and quantitative CT measures of emphysema and airway disease. MATERIALS AND METHODS: This research protocol was approved by the institutional review board of each participating institution, and all participants provided written informed consent. One thousand two subjects who were enrolled in the COPDGene Study and met the GOLD (Global Initiative for Chronic Obstructive Lung Disease) criteria for COPD with quantitative CT analysis were included. Total lung emphysema percentage was measured by using the attenuation mask technique with a -950-HU threshold. An automated program measured the mean wall thickness and mean wall area percentage in six segmental bronchi. The frequency of COPD exacerbation in the prior year was determined by using a questionnaire. Statistical analysis was performed to examine the relationship of exacerbation frequency with lung function and quantitative CT measurements. RESULTS: In a multivariate analysis adjusted for lung function, bronchial wall thickness and total lung emphysema percentage were associated with COPD exacerbation frequency. Each 1-mm increase in bronchial wall thickness was associated with a 1.84-fold increase in annual exacerbation rate (P = .004). For patients with 35% or greater total emphysema, each 5% increase in emphysema was associated with a 1.18-fold increase in this rate (P = .047). CONCLUSION: Greater lung emphysema and airway wall thickness were associated with COPD exacerbations, independent of the severity of airflow obstruction. Quantitative CT can help identify subgroups of patients with COPD who experience exacerbations for targeted research and therapy development for individual phenotypes.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Vestbo, J., Hurd, S. S., Agustí, A. G., Jones, P. W., Vogelmeier, C., Anzueto, A., Barnes, P. J., Fabbri, L. M., Martinez, F. J., Nishimura, M., et al. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201204-0596pp · Cited by 15,983
Self-citationRabe, K. F., Hurd, S., Anzueto, A., Barnes, P. J., Buist, S. A., Calverley, P., Fukuchi, Y., Jenkins, C., Rodriguez-Roisin, R., van Weel, C., et al. (2007) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200703-456so · Cited by 4,925
Self-citationCelli, B. R., Cote, C. G., Marin, J. M., Casanova, C., Montes de Oca, M., Mendez, R. A., Pinto Plata, V., & Cabral, H. J. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa021322 · Cited by 4,015
Characterisation of COPD heterogeneity in the ECLIPSE cohort
the Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) investigators, Agusti, A., Calverley, P. M., Celli, B., Coxson, H. O., Edwards, L. D., Lomas, D. A., MacNee, W., Miller, B. E., Rennard, S., et al. (2010) · Respiratory Research · doi:10.1186/1465-9921-11-122 · Cited by 1,157
Self-citationSex Differences in Severe Pulmonary Emphysema
Martinez, F. J., Curtis, J. L., Sciurba, F., Mumford, J., Giardino, N. D., Weinmann, G., Kazerooni, E., Murray, S., Criner, G. J., Sin, D. D., et al. (2007) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200606-828oc · Cited by 365
Self-citation
Cited by
Vogelmeier, C. F., Criner, G. J., Martinez, F. J., Anzueto, A., Barnes, P. J., Bourbeau, J., Celli, B. R., Chen, R., Decramer, M., Fabbri, L. M., et al. (2017) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201701-0218pp · Cited by 3,187
Self-citationSchroeder, J. D., McKenzie, A. S., Zach, J. A., Wilson, C. G., Curran-Everett, D., Stinson, D. S., Newell, J. D., & Lynch, D. A. (2013) · American Journal of Roentgenology · doi:10.2214/ajr.12.10102 · Cited by 334
Self-citationHospitalized Exacerbations of COPD
Müllerova, H., Maselli, D. J., Locantore, N., Vestbo, J., Hurst, J. R., Wedzicha, J. A., Bakke, P., Agusti, A., & Anzueto, A. (2015) · Chest · doi:10.1378/chest.14-0655 · Cited by 320
Self-citationHan, M. K., Quibrera, P. M., Carretta, E. E., Barr, R. G., Bleecker, E. R., Bowler, R. P., Cooper, C. B., Comellas, A., Couper, D. J., Curtis, J. L., et al. (2017) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(17)30207-2 · Cited by 319
Self-citationGuía Española de la EPOC (GesEPOC). Tratamiento farmacológico de la EPOC estable
Miravitlles, M., Soler-Cataluña, J. J., Calle, M., Molina, J., Almagro, P., Quintano, J. A., Riesco, J. A., Trigueros, J. A., Piñera, P., Simón, A., et al. (2012) · Archivos de Bronconeumología · doi:10.1016/j.arbres.2012.04.001 · Cited by 257
Metadata
- Authors
- Han, M. K., Kazerooni, E. A., Lynch, D. A., Liu, L. X., Murray, S., Curtis, J. L., Criner, G. J., Kim, V., Bowler, R. P., Hanania, N. A., Anzueto, A. R., Make, B. J., Hokanson, J. E., Crapo, J. D., Silverman, E. K., Martinez, F. J., & Washko, G. R.
- Venue
- Radiology
- Published
- 2011-10
- Volume
- 261
- Issue
- 1
- Pages
- 274-282
- ISSN
- 0033-8419 (ISSN-L)
- 1527-1315
- OpenAlex
- W2020707691
- Cited by
- 453
- References
- 5
- FWCI
- 26.48
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Chronic Obstructive Pulmonary Disease Exacerbations in the COPDGene Study: Associated Radiologic Phenotypes. https://app.cochat.ai/papers/10.1148/radiol.11110173
- The paper
- Han, M. K., Kazerooni, E. A., Lynch, D. A., Liu, L. X., Murray, S., Curtis, J. L., Criner, G. J., Kim, V., Bowler, R. P., Hanania, N. A., Anzueto, A. R., Make, B. J., Hokanson, J. E., Crapo, J. D., Silverman, E. K., Martinez, F. J., & Washko, G. R. (2011). Chronic Obstructive Pulmonary Disease Exacerbations in the COPDGene Study: Associated Radiologic Phenotypes. Radiology. https://doi.org/10.1148/radiol.11110173
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
