The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Comparison of 68Ga-FAPI and 18F-FDG Uptake in Gastric, Duodenal, and Colorectal Cancers
Open accessAbstract
Background: Accurate clinical staging is crucial to managing gastrointestinal cancer, but fluorine 18 ( 18 F) fluorodeoxyglucose (FDG) PET/CT has limitations.Targeting fibroblast-activation protein is a newer diagnostic approach for the visualization of tumor stroma, and gallium 68 ( 68 Ga)-labeled fibroblast-activation protein inhibitors (FAPIs), hereafter 68 Ga-FAPIs, present a promising alternative to 18 F-FDG.Purpose: To compare the diagnostic efficacy of 68 Ga-FAPI PET/CT in primary and metastatic lesions of gastrointestinal malignancies with that of 18 F-FDG PET/CT. Materials and Methods:Images from patients with gastric, duodenal, and colorectal cancers who underwent contemporaneous 18 F-FDG and 68 Ga-FAPI PET/CT between October 2019 through June 2020 were retrospectively analyzed.18 F-FDG and 68 Ga-FAPI uptakes were compared by using the Wilcoxon signed-rank test.The McNemar test was used to compare the diagnostic performance between the two techniques.Results: Thirty-five patients (median age, 64 years [interquartile range, 53-68 years]; 18 men) were evaluated.In treatment-naive patients (n = 19), 68 Ga-FAPI PET/CT led to upstaging of the clinical TNM stage in four (21%) patients compared with 18 F-FDG PET/CT.Tracer uptake was higher with 68 Ga-FAPI PET/CT than with 18 F-FDG PET/CT in primary lesions (gastric cancer: 12.7 vs 3.7, respectively, P = .003;colorectal cancer: 15.9 vs 7.9, P = .03),involved lymph nodes (6.7 vs 2.4, P , .001), and bone and visceral metastases (liver metastases: 9.7 vs 5.2, P , .001;peritoneal metastases: 8.4 vs 3.6, P , .001;bone metastases: 4.3 vs 2.2, P , .001;lung metastases: 4.4 vs 1.9, P = .01).In addition, the sensitivity of 68 Ga-FAPI PET/CT was higher than that of 18 F-FDG PET/CT in the detection of primary tumors (100% [19 of 19] vs 53% [10 of 19], respectively; P = .004),lymph nodes (79% [22 of 28] vs 54% [15 of 28], P , .001), and bone and visceral metastases (89% [31 of 35] vs 57% [20 of 35], P , .001).Conclusion: Gallium 68 fibroblast-activation protein inhibitor PET/CT was superior to fluorine 18 fluorodeoxyglucose PET/CT in the detection of primary and metastatic lesions in gastric, duodenal, and colorectal cancers, with higher tracer uptake in most primary and metastatic lesions.
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68Ga-FAPI PET/CT: Tracer Uptake in 28 Different Kinds of Cancer
Kratochwil, C., Flechsig, P., Lindner, T., Abderrahim, L., Altmann, A., Mier, W., Adeberg, S., Rathke, H., Röhrich, M., Winter, H., et al. (2019) · Journal of Nuclear Medicine · doi:10.2967/jnumed.119.227967 · Cited by 1,464
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Clinical Applications of PET in Oncology
Rohren, E. M., Turkington, T. G., & Coleman, R. E. (2004) · Radiology · doi:10.1148/radiol.2312021185 · Cited by 859
A Tumor-Imaging Method Targeting Cancer-Associated Fibroblasts
Loktev, A., Lindner, T., Mier, W., Debus, J., Altmann, A., Jäger, D., Giesel, F., Kratochwil, C., Barthe, P., Roumestand, C., et al. (2018) · Journal of Nuclear Medicine · doi:10.2967/jnumed.118.210435 · Cited by 777
Giesel, F. L., Kratochwil, C., Lindner, T., Marschalek, M. M., Loktev, A., Lehnert, W., Debus, J., Jäger, D., Flechsig, P., Altmann, A., et al. (2019) · Journal of Nuclear Medicine · doi:10.2967/jnumed.118.215913 · Cited by 740
Chen, H., Pang, Y., Wu, J., Zhao, L., Hao, B., Wu, J., Wei, J., Wu, S., Zhao, L., Luo, Z., et al. (2020) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-020-04769-z · Cited by 545
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Strating, E., Wassenaar, E., Verhagen, M., Rauwerdink, P., van Schelven, S., de Hingh, I., Rinkes, I. B., Boerma, D., Witkamp, A., Lacle, M., et al. (2022) · British Journal of Cancer · doi:10.1038/s41416-022-01748-z · Cited by 36
Metadata
- Authors
- Pang, Y., Zhao, L., Luo, Z., Hao, B., Wu, H., Lin, Q., Sun, L., & Chen, H.
- Venue
- Radiology
- Published
- 2021-02
- Volume
- 298
- Issue
- 2
- Pages
- 393-402
- ISSN
- 0033-8419 (ISSN-L)
- 1527-1315
- OpenAlex
- W3109525285
- Cited by
- 298
- References
- 20
- FWCI
- 13.55
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Pang, Y., Zhao, L., Luo, Z., Hao, B., Wu, H., Lin, Q., Sun, L., & Chen, H. (2021). Comparison of 68Ga-FAPI and 18F-FDG Uptake in Gastric, Duodenal, and Colorectal Cancers. Radiology. https://doi.org/10.1148/radiol.2020203275
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