The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Effects of Nonionic Intravenous Contrast Agents at PET/CT Imaging: Phantom and Canine Studies
Abstract
Purpose To investigate the effects of intravenous contrast agents on quantitative values obtained with a combined positron emission tomographic (PET) and computed tomographic (CT) scanner by using several phantoms and a dog. Materials and methods Fluorine 18 fluorodeoxyglucose (FDG) was mixed with different concentrations of contrast agent with the same syringe (phantom 1), and the phantom was scanned. After image reconstruction with various attenuation maps, radioactivity concentrations were compared. Then, FDG solutions with (phantom 2) or surrounded by (phantom 3) various concentrations of contrast agent were scanned repeatedly, and radioactivity concentration was compared. Finally, PET and CT with and without contrast agent were performed in a dog. PET images were reconstructed by using different attenuation maps, and radioactivity concentrations were compared. The radioactivity concentration on germanium 68 (68Ge)-based corrected images was regarded as standard, and percentage bias, defined as difference divided by measured activity of 68Ge-based corrected images, was assessed. The relationship between the concentration of contrast agent and the percentage bias was assessed with the Pearson coefficient r, and the significance of correlations was evaluated with the Fisher z test. Results All phantom studies demonstrated that presence of a contrast agent resulted in overestimation of emission data. CT numbers showed a strong positive correlation with the percentage bias in…
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“However, in organs with a particularly high concentration of the contrast agent (e.g., the liver, kidney, or blood vessels), these deviations can be higher [116,120,121].”
From Influences on PET Quantification and Interpretation (2022) · cites this paper as [120]
Citations
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Metadata
- Authors
- Nakamoto, Y., Chin, B. B., Kraitchman, D. L., Lawler, L. P., Marshall, L. T., & Wahl, R. L.
- Affiliations
- Johns Hopkins Medicine (US)
- Johns Hopkins University (US)
- Venue
- Radiology
- Published
- 2003-06
- Volume
- 227
- Issue
- 3
- Pages
- 817-824
- ISSN
- 0033-8419 (ISSN-L)
- 1527-1315
- OpenAlex
- W1995453959
- Cited by
- 111
- References
- 17
- Citations by year
- 2024: 1 · 2022: 1 · 2020: 1 · 2019: 2 · 2018: 4 · 2017: 3 · 2016: 1 · 2015: 3 · 2014: 3 · 2013: 6 · 2012: 7
- FWCI
- 10.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Radiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
- Physical Sciences › Engineering › Biomedical Engineering › Advanced X-ray and CT Imaging
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
- Keywords
- PET/CT, fluorodeoxyglucose, attenuation correction, attenuation map, Hounsfield units, phantom study, canine model, PET quantification
- MeSH terms
- Animals, Contrast Media, Dogs, Humans, Image Processing, Computer-Assisted, Injections, Intravenous, Tomography, Emission-Computed, Tomography, X-Ray Computed, Phantoms, Imaging, Radiopharmaceuticals, Fluorodeoxyglucose F18
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