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Hepatocellular Carcinoma: Regional Therapy with a Magnetic Targeted Carrier Bound to Doxorubicin in a Dual MR Imaging/ Conventional Angiography Suite—Initial Experience with Four Patients
Abstract
Four patients with inoperable hepatocellular carcinoma were treated with a magnetic targeted carrier bound to doxorubicin (MTC-DOX) by using a joint magnetic resonance (MR) imaging/conventional angiography system consisting of a 1.5-T short-bore magnet connected to a C-arm angiography unit by a sliding tabletop. Selective transcatheter delivery of the MTC-DOX to the hepatic artery was monitored by using intraprocedural MR imaging, and interim catheter manipulation was performed with fluoroscopic guidance to optimize agent delivery to the tumor and minimize delivery to normal tissue. The final fraction of treated tumor volume ranged from 0.64 to 0.91. The fraction of affected normal liver volume ranged from 0.07 to 0.30. The dual MR imaging/conventional angiography system shows promise for directing magnetically targeted tumor therapies.
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“From a translational point of view, only one magnetically targeted nanocarrier (which was loaded with doxorubicin; MTC-DOX) has been evaluated in patients, but it did not produce convincing results, leading to termination of clinical development in phase II/III [232, 233].”
From Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications (2019) · cites this paper as [232]
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Metadata
- Authors
- Wilson, M. W., Kerlan, R. K., Fidelman, N. A., Venook, A. P., LaBerge, J. M., Koda, J., & Gordon, R. L.
- Affiliations
- University of California, San Francisco (US)
- Venue
- Radiology
- Published
- 2004-01
- Volume
- 230
- Issue
- 1
- Pages
- 287-293
- ISSN
- 0033-8419 (ISSN-L)
- 1527-1315
- OpenAlex
- W2169532237
- Cited by
- 190
- References
- 15
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 3 · 2023: 7 · 2022: 5 · 2021: 7 · 2020: 8 · 2019: 11 · 2018: 7 · 2017: 10 · 2016: 13 · 2015: 10 · 2014: 9 · 2013: 9 · 2012: 9
- FWCI
- 3.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Radiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hepatology › Hepatocellular Carcinoma Treatment and Prognosis
- Physical Sciences › Engineering › Biomedical Engineering › Ultrasound and Hyperthermia Applications
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- hepatocellular carcinoma, doxorubicin, hepatic artery, fluoroscopic guidance, tumor targeting, inoperable liver cancer
- MeSH terms
- Adult, Aged, Angiography, Antibiotics, Antineoplastic, Doxorubicin, Drug Carriers, Equipment Design, Female, Carcinoma, Hepatocellular, Humans, Liver Neoplasms, Magnetic Resonance Imaging, Magnetics, Male, Middle Aged
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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