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Simultaneous MR/PET Imaging of the Human Brain: Feasibility Study
Abstract
The purpose of this study was to apply a magnetic resonance (MR) imaging-compatible positron emission tomographic (PET) detector technology for simultaneous MR/PET imaging of the human brain and skull base. The PET detector ring consists of lutetium oxyorthosilicate (LSO) scintillation crystals in combination with avalanche photodiodes (APDs) mounted in a clinical 3-T MR imager with use of the birdcage transmit/receive head coil. Following phantom studies, two patients were simultaneously examined by using fluorine 18 fluorodeoxyglucose (FDG) PET and MR imaging and spectroscopy. MR/PET data enabled accurate coregistration of morphologic and multifunctional information. Simultaneous MR/PET imaging is feasible in humans, opening up new possibilities for the emerging field of molecular imaging.
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Cited by
Drzezga, A., Souvatzoglou, M., Eiber, M., Beer, A. J., Fürst, S., Martinez-Möller, A., Nekolla, S. G., Ziegler, S., Ganter, C., Rummeny, E. J., et al. (2012) · Journal of Nuclear Medicine · doi:10.2967/jnumed.111.098608 · Cited by 508
Nanoparticles as contrast agents for in-vivo bioimaging: current status and future perspectives
Hahn, M. A., Singh, A. K., Sharma, P., Brown, S. C., & Moudgil, B. M. (2011) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-010-4207-5 · Cited by 485
PET/MRI: Paving the Way for the Next Generation of Clinical Multimodality Imaging Applications
Pichler, B. J., Kolb, A., Nägele, T., & Schlemmer, H.-P. (2010) · Journal of Nuclear Medicine · doi:10.2967/jnumed.109.061853 · Cited by 418
Self-citationBerker, Y., Franke, J., Salomon, A., Palmowski, M., Donker, H. C. W., Temur, Y., Mottaghy, F. M., Kuhl, C., Izquierdo-Garcia, D., Fayad, Z. A., et al. (2012) · Journal of Nuclear Medicine · doi:10.2967/jnumed.111.092577 · Cited by 344
Johansson, A., Karlsson, M., & Nyholm, T. (2011) · Medical Physics · doi:10.1118/1.3578928 · Cited by 324
Metadata
- Authors
- Schlemmer, H.-P. W., Pichler, B. J., Schmand, M., Burbar, Z., Michel, C., Ladebeck, R., Jattke, K., Townsend, D., Nahmias, C., Jacob, P. K., Heiss, W.-D., & Claussen, C. D.
- Venue
- Radiology
- Published
- 2008-09
- Volume
- 248
- Issue
- 3
- Pages
- 1028-1035
- ISSN
- 0033-8419 (ISSN-L)
- 1527-1315
- OpenAlex
- W2105254502
- Cited by
- 474
- References
- 0
- FWCI
- 30.34
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Simultaneous MR/PET Imaging of the Human Brain: Feasibility Study. https://app.cochat.ai/papers/10.1148/radiol.2483071927
- The paper
- Schlemmer, H.-P. W., Pichler, B. J., Schmand, M., Burbar, Z., Michel, C., Ladebeck, R., Jattke, K., Townsend, D., Nahmias, C., Jacob, P. K., Heiss, W.-D., & Claussen, C. D. (2008). Simultaneous MR/PET Imaging of the Human Brain: Feasibility Study. Radiology. https://doi.org/10.1148/radiol.2483071927
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