PET/MRI: Paving the Way for the Next Generation of Clinical Multimodality Imaging Applications
Open accessAbstract
Multimodality imaging and, more specifically, the combination of PET and CT has matured into an important diagnostic tool. During the same period, concepts for PET scanners integrated into an MR tomograph have emerged. The excellent soft-tissue contrast of MRI and the multifunctional imaging options it offers, such as spectroscopy, functional MRI, and arterial spin labeling, complement the molecular information of PET. The development of a fully integrated PET/MRI system is technologically challenging. It requires not only significant modifications of the PET detector to make it compact and insensitive to magnetic fields but also a major redesign of the MRI hardware.
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Combining radiopharmaceutical techniques with other diagnostic methods, such as PET and MRI, provides complementary anatomical and functional information, improving diagnostic accuracy in neurological disorders.
“The integration of radiopharmaceutical techniques with other diagnostic methods, such as the combination of PET and MRI, provides complementary anatomical and functional information, improving diagnostic accuracy in neurological disorders [44].”
From Radiopharmaceuticals: navigating the frontier of precision medicine and therapeutic innovation (2024) · cites this paper as [44]
The Abstract says MRI’s soft-tissue contrast complements PET’s molecular information. In “Clinical Potential of PET/MRI” (page unavailable), the paper describes a brain-tumor case in which combining the images revealed disease extent that neither modality showed fully alone. It presents broader benefits for neurological disorders as expectations, rather than establishing a general improvement in diagnostic accuracy. (LLM, conf=0.85)
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Self-citation
- Authors
- Pichler, B. J., Kolb, A., Nägele, T., & Schlemmer, H.-P.
- Affiliations
- University of Tübingen (DE)
- Venue
- Journal of Nuclear Medicine
- Publisher
- Society of Nuclear Medicine
- Published
- 2010-02-11
- Volume
- 51
- Issue
- 3
- Pages
- 333-336
- ISSN
- 0161-5505 (ISSN-L)
- 2159-662X
- OpenAlex
- W2015447436
- Cited by
- 418
- References
- 25
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 10 · 2023: 13 · 2022: 16 · 2021: 12 · 2020: 18 · 2019: 18 · 2018: 26 · 2017: 32 · 2016: 34 · 2015: 42 · 2014: 47 · 2013: 55 · 2012: 39
- FWCI
- 36.91
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Nuclear Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft (PI771, SFB 773)
- National Institutes of Health
- National Institute of Biomedical Imaging and Bioengineering (R21EB004483)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
- Keywords
- PET/MRI, multimodal imaging, PET/CT, PET detector design, magnetic field insensitivity, soft tissue contrast, functional MRI, arterial spin labeling, MRI spectroscopy, molecular imaging
- MeSH terms
- Adult, Aged, Brain Neoplasms, Female, Humans, Liver Neoplasms, Magnetic Resonance Imaging, Meningioma, Middle Aged, Ovarian Neoplasms, Positron-Emission Tomography, Whole Body Imaging
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