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Ferrite particles: a superparamagnetic MR contrast agent for the reticuloendothelial system.
Abstract
The potential of superparamagnetic ferrite particles as a contrast agent for magnetic resonance (MR) imaging was studied by in vitro MR spectroscopy and in vivo MR imaging in laboratory animals. After aqueous preparations of ferrite particles were administered intravenously, MR spectroscopy showed greatly decreased T2 relaxation times of liver and spleen, with only minimally altered T1, and no changes in lung, kidney, or muscle. Effects occurred within 30 minutes of injection and persisted for more than 6 months. MR imaging with pulse sequences that provide T2-dependent contrast demonstrated that ferrite produced profound signal loss from liver, spleen, and bone marrow. Sequestration of ferrite particles in hepatic reticuloendothelial cells was confirmed by means of light and electron microscopy. Because ferrite has a potent effect on MR signal and exhibits tissue-specific localization, it warrants further study as a contrast agent for MR imaging of the reticuloendothelial system (i.e., liver, spleen, and bone marrow).
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Cited by
Imaging iron stores in the brain using magnetic resonance imaging
Haacke, E. M., Cheng, N. Y. C., House, M. J., Liu, Q., Neelavalli, J., Ogg, R. J., Khan, A., Ayaz, M., Kirsch, W., & Obenaus, A. (2005) · Magnetic Resonance Imaging · doi:10.1016/j.mri.2004.10.001 · Cited by 995
Villaraza, A. J. L., Bumb, A., & Brechbiel, M. W. (2010) · Chemical Reviews · doi:10.1021/cr900232t · Cited by 632
Long-circulating iron oxides for MR imaging
Weissleder, R., Bogdanov, A., Neuwelt, E. A., & Papisov, M. (1995) · Advanced Drug Delivery Reviews · doi:10.1016/0169-409x(95)00033-4 · Cited by 398
Cell-penetrating peptides as delivery vehicles for biology and medicine
Stewart, K. M., Horton, K. L., & Kelley, S. O. (2008) · Organic & Biomolecular Chemistry · doi:10.1039/b719950c · Cited by 381
Gillis, P., & Koenig, S. H. (1987) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910050404 · Cited by 353
Metadata
- Authors
- Saini, S., Stark, D. D., Hahn, P. F., Wittenberg, J., Brady, T. J., & Ferrucci, J. T.
- Venue
- Radiology
- Published
- 1987-01
- Volume
- 162
- Issue
- 1
- Pages
- 211-216
- ISSN
- 0033-8419 (ISSN-L)
- 1527-1315
- OpenAlex
- W2149874407
- Cited by
- 230
- References
- 0
- FWCI
- 11.04
- Type
- journal article
- Language
- en
- Open access
- closed
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- Saini, S., Stark, D. D., Hahn, P. F., Wittenberg, J., Brady, T. J., & Ferrucci, J. T. (1987). Ferrite particles: a superparamagnetic MR contrast agent for the reticuloendothelial system. Radiology. https://doi.org/10.1148/radiology.162.1.3786765
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