The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Normal maturation of the neonatal and infant brain: MR imaging at 1.5 T.
Abstract
The pattern of normal white-matter maturation as demonstrated with high-field-strength magnetic resonance (MR) imaging was investigated. Eighty-two neurologically normal infants were examined with a 1.5-T unit with use of spin-echo T1-weighted and T2-weighted pulse sequences. The infants ranged in age from 4 days to 2 years. The images were assessed for qualitative changes of white matter relative to gray matter in 14 anatomic areas of the brain and correlated with the patient's age. The MR images showed that changes of brain maturation occur in an orderly manner, commencing in the brain stem and progressing to the cerebellum and the cerebrum. Changes caused by brain myelination were seen earlier on T1-weighted images than on T2-weighted images, possibly because of T1 shortening by the components of the developing myelin sheaths. The later changes on the T2-weighted images correlated best with the development of myelination as demonstrated with histochemical methods. T1-weighted images were most useful in the monitoring of normal brain development in the first 6-8 months of life; T2-weighted images were more useful after 6 months. The milestones in the MR appearance of normal maturation of the brain are presented. Persistent areas of long T2 relaxation times are seen superior and dorsal to the ventricular trigone in all infants examined and should not be mistaken for ischemic change.
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Cites
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Clinical NMR imaging of the brain in children: normal and neurologic disease
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Lipid and Fatty Acid Composition of Human Cerebral Myelin during Development
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Cited by
Brain development in children and adolescents: Insights from anatomical magnetic resonance imaging
Lenroot, R. K., & Giedd, J. N. (2006) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2006.06.001 · Cited by 1,863
Blümcke, I., Thom, M., Aronica, E., Armstrong, D. D., Vinters, H. V., Palmini, A., Jacques, T. S., Avanzini, G., Barkovich, A. J., Battaglia, G., et al. (2011) · Epilepsia · doi:10.1111/j.1528-1167.2010.02777.x · Cited by 1,743
Self-citationNormal development of brain circuits
Tau, G. Z., & Peterson, B. S. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.115 · Cited by 1,391
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Sowell, E. R., Thompson, P. M., Tessner, K. D., & Toga, A. W. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-22-08819.2001 · Cited by 983
“Regressive (i.e., synaptic pruning) and progressive (i.e., myelination) cellular events are known to occur simultaneously in the brain during childhood, adolescence, and young adulthood, both of which could result in the appearance of gray matter density reduction or cortical thinning on MRI.”
BackgroundInfluential
Metadata
- Authors
- Barkovich, A. J., Kjos, B. O., Jackson, D. E., & Norman, D.
- Venue
- Radiology
- Published
- 1988-01
- Volume
- 166
- Issue
- 1
- Pages
- 173-180
- ISSN
- 0033-8419 (ISSN-L)
- 1527-1315
- OpenAlex
- W2123421700
- Cited by
- 744
- References
- 6
- FWCI
- 26.54
- Type
- journal article
- Language
- en
- Open access
- closed
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- Barkovich, A. J., Kjos, B. O., Jackson, D. E., & Norman, D. (1988). Normal maturation of the neonatal and infant brain: MR imaging at 1.5 T. Radiology. https://doi.org/10.1148/radiology.166.1.3336675
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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