The DOI matches its Crossref record.
Degenerative disk disease: assessment of changes in vertebral body marrow with MR imaging.
Abstract
The authors reviewed magnetic resonance (MR) images of 474 consecutive patients referred for lumbar spine MR imaging. Type 1 changes (decreased signal intensity on T1-weighted spin-echo images and increased signal intensity on T2-weighted images) were identified in 20 patients (4%) and type 2 (increased signal intensity on T1-weighted images and isointense or slightly increased signal intensity on T2-weighted images) in 77 patients (16%). In all cases there was evidence of associated degenerative disk disease at the level of involvement. Histopathologic sections in three cases of type 1 change demonstrated disruption and fissuring of the end plates and vascularized fibrous tissue, while in three cases of type 2 change they demonstrated yellow marrow replacement. In addition, 16 patients with end-plate changes documented with MR were studied longitudinally. Type 1 changes in five of six patients converted to a type 2 pattern in 14 months to 3 years. Type 2 changes in ten patients remained stable over a 2-3-year period. These signal intensity changes appear to reflect a spectrum of vertebral body marrow changes associated with degenerative disk disease.
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Citations
Cited by
Lumbar Degenerative Disk Disease
Modic, M. T., & Ross, J. S. (2007) · Radiology · doi:10.1148/radiol.2451051706 · Cited by 499
Self-citationJensen, T. S., Karppinen, J., Sorensen, J. S., Niinimäki, J., & Leboeuf-Yde, C. (2008) · European Spine Journal · doi:10.1007/s00586-008-0770-2 · Cited by 470
Modic changes and their associations with clinical findings
Kjaer, P., Korsholm, L., Bendix, T., Sorensen, J. S., & Leboeuf-Yde, C. (2006) · European Spine Journal · doi:10.1007/s00586-006-0185-x · Cited by 314
Nouri, A., Martin, A. R., Mikulis, D., & Fehlings, M. G. (2016) · Neurosurgical Focus · doi:10.3171/2016.3.focus1667 · Cited by 218
Hellum, C., Johnsen, L. G., Storheim, K., Nygaard, O. P., Brox, J. I., Rossvoll, I., Ro, M., Sandvik, L., Grundnes, O., & and the Norwegian Spine Study Group (2011) · BMJ · doi:10.1136/bmj.d2786 · Cited by 116
Metadata
- Authors
- Modic, M. T., Steinberg, P. M., Ross, J. S., Masaryk, T. J., & Carter, J. R.
- Venue
- Radiology
- Published
- 1988-01
- Volume
- 166
- Issue
- 1
- Pages
- 193-199
- ISSN
- 0033-8419 (ISSN-L)
- 1527-1315
- OpenAlex
- W2141302405
- Cited by
- 2,061
- References
- 0
- FWCI
- 8.36
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Degenerative disk disease: assessment of changes in vertebral body marrow with MR imaging. https://app.cochat.ai/papers/10.1148/radiology.166.1.3336678
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- Modic, M. T., Steinberg, P. M., Ross, J. S., Masaryk, T. J., & Carter, J. R. (1988). Degenerative disk disease: assessment of changes in vertebral body marrow with MR imaging. Radiology. https://doi.org/10.1148/radiology.166.1.3336678
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
