The DOI matches its Crossref record; 67 of the 67 references it cites were found in a registry or an index.
Lumbar Degenerative Disk Disease
Abstract
The sequelae of disk degeneration are among the leading causes of functional incapacity in both sexes and are a common source of chronic disability in the working years. Disk degeneration involves structural disruption and cell-mediated changes in composition. Mechanical, traumatic, nutritional, and genetic factors all may play a role in the cascade of disk degeneration, albeit to variable degree in different individuals. The presence of degenerative change is by no means an indicator of symptoms, and there is a very high prevalence in asymptomatic individuals. The etiology of pain as the symptom of degenerative disease is complex and appears to be a combination of mechanical deformation and the presence of inflammatory mediators. The role of imaging is to provide accurate morphologic information and influence therapeutic decision making. A necessary component, which connects these two purposes, is accurate natural history data. Understanding the relationship of etiologic factors, the morphologic alterations, which can be characterized with imaging, and the mechanisms of pain production and their interactions in the production of symptoms will require more accurate and reproducible stratification of patient cohorts.
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Citations
Cites
Magnetic Resonance Classification of Lumbar Intervertebral Disc Degeneration
Pfirrmann, C. W. A., Metzdorf, A., Zanetti, M., Hodler, J., & Boos, N. (2001) · Spine · doi:10.1097/00007632-200109010-00011 · Cited by 4,012
Boden, S. D., McCowin, P. R., Davis, D. O., Dina, T. S., Mark, A. S., & Wiesel, S. (1990) · The Journal of Bone & Joint Surgery · doi:10.2106/00004623-199072080-00008 · Cited by 2,708
Magnetic Resonance Imaging of the Lumbar Spine in People without Back Pain
Jensen, M. C., Brant-Zawadzki, M. N., Obuchowski, N., Modic, M. T., Malkasian, D., & Ross, J. S. (1994) · New England Journal of Medicine · doi:10.1056/nejm199407143310201 · Cited by 2,402
Self-citationBoden, S. D., Davis, D. O., Dina, T. S., Patronas, N. J., & Wiesel, S. W. (1990) · The Journal of Bone & Joint Surgery · doi:10.2106/00004623-199072030-00013 · Cited by 2,115
Degenerative disk disease: assessment of changes in vertebral body marrow with MR imaging.
Modic, M. T., Steinberg, P. M., Ross, J. S., Masaryk, T. J., & Carter, J. R. (1988) · Radiology · doi:10.1148/radiology.166.1.3336678 · Cited by 2,061
Self-citationRupture of the Intervertebral Disc with Involvement of the Spinal Canal
MIXTER, W. J., & BARR, J. S. (1934) · New England Journal of Medicine · doi:10.1056/nejm193408022110506 · Cited by 1,907
Nerve ingrowth into diseased intervertebral disc in chronic back pain
Freemont, A., Peacock, T., Goupille, P., Hoyland, J., O'Brien, J., & Jayson, M. (1997) · The Lancet · doi:10.1016/s0140-6736(97)02135-1 · Cited by 989
Abnormal Magnetic-Resonance Scans of the Lumbar Spine in Asymptomatic Subjects
Boden, S. D., Dina, T. S., Patronas, N. J., & Wiesel, S. W. (1990) · Cited by 770
WIESEL, S. W., TSOURMAS, N., FEFFER, H. L., CITRIN, C. M., & PATRONAS, N. (1984) · Spine · doi:10.1097/00007632-198409000-00003 · Cited by 720
Katz, J. N., & Harris, M. B. (2008) · New England Journal of Medicine · doi:10.1056/nejmcp0708097 · Cited by 704
Cited by
Prevention and management of chronic back pain
Weiner, S. S., & Nordin, M. (2010) · Best Practice & Research Clinical Rheumatology · doi:10.1016/j.berh.2009.12.001 · Cited by 119
The Chimera of Low Back Pain Etiology: A Clinical Rehabilitation Perspective
Negrini, S., & Zaina, F. (2013) · American Journal of Physical Medicine & Rehabilitation · doi:10.1097/phm.0b013e31827df8f5 · Cited by 33
Metadata
- Authors
- Modic, M. T., & Ross, J. S.
- Venue
- Radiology
- Published
- 2007-10
- Volume
- 245
- Issue
- 1
- Pages
- 43-61
- ISSN
- 0033-8419 (ISSN-L)
- 1527-1315
- OpenAlex
- W2136377548
- Cited by
- 499
- References
- 67
- FWCI
- 10.98
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
