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Gd-DOTA: characterization of a new paramagnetic complex.
Abstract
The relaxivity, biodistribution, and toxicity of the gadolinium-tetraazacyclododecanetetraacetic acid (Gd-DOTA) complex were evaluated. This cyclic complex has much greater in vitro stability (10(28)) than similar noncyclic complexes such as gadolinium-diethylenetriaminepentaacetic acid (Gd-DTPA) (10(23)) or gadolinium-ethylenediaminetetraacetic acid (Gd-EDTA) (10(17)). The T1 relaxivity of Gd-DOTA (meglumine salt) determined in saline and in liver tissue at 20 MHz was similar to the relaxivity of Gd-DTPA. Tissue proton relaxation enhancement (PRE) correlated closely with chemical measurement of tissue gadolinium concentration. In rats, the biodistribution of Gd-DOTA was similar to Gd-DTPA with a distribution half-life of 3 minutes and an elimination half-life of 18 minutes. The median lethal dose (LD50) in mice of Gd-DOTA was 93% higher than that of Gd-DTPA; the calculated safety factor (ratio of LD50 to effective dose) was 53 for Gd-DOTA and 28 for Gd-DTPA. The data suggest that in vitro stability correlates with in vivo safety.
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Cited by
Lanthanide induced shifts and relaxation rate enhancements
Peters, J. A., Huskens, J., & Raber, D. J. (1996) · Progress in Nuclear Magnetic Resonance Spectroscopy · doi:10.1016/0079-6565(95)01026-2 · Cited by 508
Laurent, S., Elst, L. V., & Muller, R. N. (2006) · Contrast Media & Molecular Imaging · doi:10.1002/cmmi.100 · Cited by 441
Lerat-Hardy, A., Coynel, A., Dutruch, L., Pereto, C., Bossy, C., Gil-Diaz, T., Capdeville, M.-J., Blanc, G., & Schäfer, J. (2019) · Science of The Total Environment · doi:10.1016/j.scitotenv.2018.11.343 · Cited by 113
Metadata
- Authors
- Bousquet, J. C., Saini, S., Stark, D. D., Hahn, P. F., Nigam, M., Wittenberg, J., & Ferrucci, J. T.
- Venue
- Radiology
- Published
- 1988-03
- Volume
- 166
- Issue
- 3
- Pages
- 693-698
- ISSN
- 0033-8419 (ISSN-L)
- 1527-1315
- OpenAlex
- W2090437724
- Cited by
- 257
- References
- 0
- FWCI
- 8.64
- Type
- journal article
- Language
- en
- Open access
- closed
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- Bousquet, J. C., Saini, S., Stark, D. D., Hahn, P. F., Nigam, M., Wittenberg, J., & Ferrucci, J. T. (1988). Gd-DOTA: characterization of a new paramagnetic complex. Radiology. https://doi.org/10.1148/radiology.166.3.3340763
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