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Focal pulmonary abnormalities: evaluation with F-18 fluorodeoxyglucose PET scanning.

Patz, E F, Lowe, V J, Hoffman, J M, Paine, S S, Burrowes, P, Coleman, R E, Goodman, P C·1993·Radiology

Abstract

The authors assessed the role of positron emission tomography (PET) with fluorine-18 fluorodeoxyglucose (FDG) in differentiation of benign from malignant focal pulmonary abnormalities seen on chest radiographs. Fifty-one patients underwent FDG PET scanning. Focal abnormalities at radiography included solitary pulmonary nodules (n = 38), pulmonary masses (n = 5), and poorly marginated infiltrates or opacities (n = 8). Proof of diagnosis was obtained by means of transbronchial biopsy (n = 21), open lung biopsy (n = 14), percutaneous needle biopsy (n = 14), or cytologic evaluation of sputum (n = 1). A nodule in one patient had been radiographically stable for at least 8 years. Quantitative analysis was performed by calculation of a standardized uptake ratio (SUR). Thirty-three malignant lesions had a mean SUR (+/- 1 standard deviation) of 6.5 +/- 2.9. Eighteen benign lesions had a mean SUR of 1.7 +/- 1.2. For a benign lesion with SUR of 2.5 or less, specificity of FDG PET was 100%, while sensitivity was 89%. These results suggest that FDG PET is accurate in differentiation of benign from malignant focal pulmonary abnormalities.

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Metadata

Authors
Patz, E. F., Lowe, V. J., Hoffman, J. M., Paine, S. S., Burrowes, P., Coleman, R. E., & Goodman, P. C.
Venue
Radiology
Published
1993-08
Volume
188
Issue
2
Pages
487-490
ISSN
  • 0033-8419 (ISSN-L)
  • 1527-1315
OpenAlex
W1988873933
Cited by
511
References
0
FWCI
16.14
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Focal pulmonary abnormalities: evaluation with F-18 fluorodeoxyglucose PET scanning. https://app.cochat.ai/papers/10.1148/radiology.188.2.8327702
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Patz, E. F., Lowe, V. J., Hoffman, J. M., Paine, S. S., Burrowes, P., Coleman, R. E., & Goodman, P. C. (1993). Focal pulmonary abnormalities: evaluation with F-18 fluorodeoxyglucose PET scanning. Radiology. https://doi.org/10.1148/radiology.188.2.8327702

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