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Focal pulmonary abnormalities: evaluation with F-18 fluorodeoxyglucose PET scanning.
Abstract
The authors assessed the role of positron emission tomography (PET) with fluorine-18 fluorodeoxyglucose (FDG) in differentiation of benign from malignant focal pulmonary abnormalities seen on chest radiographs. Fifty-one patients underwent FDG PET scanning. Focal abnormalities at radiography included solitary pulmonary nodules (n = 38), pulmonary masses (n = 5), and poorly marginated infiltrates or opacities (n = 8). Proof of diagnosis was obtained by means of transbronchial biopsy (n = 21), open lung biopsy (n = 14), percutaneous needle biopsy (n = 14), or cytologic evaluation of sputum (n = 1). A nodule in one patient had been radiographically stable for at least 8 years. Quantitative analysis was performed by calculation of a standardized uptake ratio (SUR). Thirty-three malignant lesions had a mean SUR (+/- 1 standard deviation) of 6.5 +/- 2.9. Eighteen benign lesions had a mean SUR of 1.7 +/- 1.2. For a benign lesion with SUR of 2.5 or less, specificity of FDG PET was 100%, while sensitivity was 89%. These results suggest that FDG PET is accurate in differentiation of benign from malignant focal pulmonary abnormalities.
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Citations
Cited by
(2001) · PubMed · Cited by 943
Zhuang, H., & Alavi, A. (2002) · Seminars in Nuclear Medicine · doi:10.1053/snuc.2002.29278 · Cited by 524
Evaluation of Patients With Pulmonary Nodules: When Is It Lung Cancer?
Gould, M. K., Fletcher, J., Iannettoni, M. D., Lynch, W. R., Midthun, D. E., Naidich, D. P., & Ost, D. E. (2007) · Chest · doi:10.1378/chest.07-1353 · Cited by 503
Antoch, G., Saoudi, N., Kuehl, H., Dahmen, G., Mueller, S. P., Beyer, T., Bockisch, A., Debatin, J. F., & Freudenberg, L. S. (2004) · Journal of Clinical Oncology · doi:10.1200/jco.2004.08.120 · Cited by 435
Staging Non-Small Cell Lung Cancer with Whole-Body PET
Marom, E. M., McAdams, H. P., Erasmus, J. J., Goodman, P. C., Culhane, D. K., Coleman, R. E., Herndon, J. E., & Patz, E. F. (1999) · Radiology · doi:10.1148/radiology.212.3.r99se21803 · Cited by 384
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Metadata
- Authors
- Patz, E. F., Lowe, V. J., Hoffman, J. M., Paine, S. S., Burrowes, P., Coleman, R. E., & Goodman, P. C.
- Venue
- Radiology
- Published
- 1993-08
- Volume
- 188
- Issue
- 2
- Pages
- 487-490
- ISSN
- 0033-8419 (ISSN-L)
- 1527-1315
- OpenAlex
- W1988873933
- Cited by
- 511
- References
- 0
- FWCI
- 16.14
- Type
- journal article
- Language
- en
- Open access
- closed
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- Patz, E. F., Lowe, V. J., Hoffman, J. M., Paine, S. S., Burrowes, P., Coleman, R. E., & Goodman, P. C. (1993). Focal pulmonary abnormalities: evaluation with F-18 fluorodeoxyglucose PET scanning. Radiology. https://doi.org/10.1148/radiology.188.2.8327702
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