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Initial clinical experience with dextran-coated superparamagnetic iron oxide for detection of lymph node metastases in patients with head and neck cancer.
Abstract
PURPOSE: To investigate the efficacy of magnetic resonance (MR) imaging with dextran-coated superparamagnetic iron oxide in the differentiation of metastatic and benign nodes in patients with head and neck cancer. MATERIALS AND METHODS: MR imaging was performed before and after intravenous administration of iron oxide in 12 patients. Ninety-one pathologically proved nodes were visually analyzed, and 66 lymph nodes were quantitatively analyzed by measuring signal intensity in visually selected regions of interest. RESULTS: Forty of 42 histologically proved metastatic nodes and 41 of 49 benign nodes were detected, yielding 95% sensitivity and 84% specificity. The signal intensity ratio of benign nodes was substantially lower than that of metastatic nodes, indicating better differentiation of metastatic and benign nodes. Furthermore, 13 of 14 normal-sized nodes were detected. CONCLUSION: MR imaging with iron oxide can enable specific differentiation of metastatic and benign nodes in patients with head and neck cancer. This agent may potentially enhance the detection of metastatic lymph nodes and deserves further investigation.
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Cited by
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Harisinghani, M. G., Barentsz, J., Hahn, P. F., Deserno, W. M., Tabatabaei, S., van de Kaa, C. H., de la Rosette, J., & Weissleder, R. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa022749 · Cited by 1,971
Wang, Y.-X. J., Hussain, S. M., & Krestin, G. P. (2001) · European Radiology · doi:10.1007/s003300100908 · Cited by 1,381
Villaraza, A. J. L., Bumb, A., & Brechbiel, M. W. (2010) · Chemical Reviews · doi:10.1021/cr900232t · Cited by 632
Heesakkers, R. A., Hövels, A. M., Jager, G. J., van den Bosch, H. C., Witjes, J. A., Raat, H. P., Severens, J. L., Adang, E. M., van der Kaa, C. H., Fütterer, J. J., et al. (2008) · The Lancet Oncology · doi:10.1016/s1470-2045(08)70203-1 · Cited by 307
Magnetite nanoparticles with tunable gold or silver shell
Mandal, M., Kundu, S., Ghosh, S. K., Panigrahi, S., Sau, T. K., Yusuf, S. M., & Pal, T. (2005) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2005.01.013 · Cited by 287
Metadata
- Authors
- Anzai, Y., Blackwell, K. E., Hirschowitz, S. L., Rogers, J. W., Sato, Y., Yuh, W. T., Runge, V. M., Morris, M. R., McLachlan, S. J., & Lufkin, R. B.
- Venue
- Radiology
- Published
- 1994-09
- Volume
- 192
- Issue
- 3
- Pages
- 709-715
- ISSN
- 0033-8419 (ISSN-L)
- 1527-1315
- OpenAlex
- W2073288904
- Cited by
- 220
- References
- 0
- FWCI
- 10.40
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Initial clinical experience with dextran-coated superparamagnetic iron oxide for detection of lymph node metastases in patients with head and neck cancer. https://app.cochat.ai/papers/10.1148/radiology.192.3.7520182
- The paper
- Anzai, Y., Blackwell, K. E., Hirschowitz, S. L., Rogers, J. W., Sato, Y., Yuh, W. T., Runge, V. M., Morris, M. R., McLachlan, S. J., & Lufkin, R. B. (1994). Initial clinical experience with dextran-coated superparamagnetic iron oxide for detection of lymph node metastases in patients with head and neck cancer. Radiology. https://doi.org/10.1148/radiology.192.3.7520182
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