Noninvasive detection of clinically occult lymph-node metastases in prostate cancer
Open accessAbstract
BACKGROUND: Accurate detection of lymph-node metastases in prostate cancer is an essential component of the approach to treatment. We investigated whether highly lymphotropic superparamagnetic nanoparticles, which gain access to lymph nodes by means of interstitial-lymphatic fluid transport, could be used in conjunction with high-resolution magnetic resonance imaging (MRI) to reveal small nodal metastases. METHODS: Eighty patients with presurgical clinical stage T1, T2, or T3 prostate cancer who underwent surgical lymph-node resection or biopsy were enrolled. All patients were examined by MRI before and 24 hours after the intravenous administration of lymphotropic superparamagnetic nanoparticles (2.6 mg of iron per kilogram of body weight). The imaging results were correlated with histopathological findings. RESULTS: Of the 334 lymph nodes that underwent resection or biopsy, 63 (18.9 percent) from 33 patients (41 percent) had histopathologically detected metastases. Of these 63 nodes, 45 (71.4 percent) did not fulfill the usual imaging criteria for malignancy. MRI with lymphotropic superparamagnetic nanoparticles correctly identified all patients with nodal metastases, and a node-by-node analysis had a significantly higher sensitivity than conventional MRI (90.5 percent vs. 35.4 percent, P<0.001) or nomograms. CONCLUSIONS: High-resolution MRI with magnetic nanoparticles allows the detection of small and otherwise undetectable lymph-node metastases in patients with prostate cancer.
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Ferumoxtran-enhanced MRI achieves significantly higher sensitivity for lymph node characterization in patients with prostate cancer than non-contrast-enhanced MRI.
“Significantly higher sensitivity for lymph node characterization in patients with prostate cancer, in which metastases detection with positron emission tomography (PET) is problematic, could be achieved by using ferumoxtran compared to non-contrast-enhanced MR imaging [160, 161].”
From Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications (2019) · cites this paper as [161]
Ferumoxtran-enhanced MRI achieves significantly higher sensitivity for lymph node characterization in patients with prostate cancer than non-contrast-enhanced MRI.
“Significantly higher sensitivity for lymph node characterization in patients with prostate cancer, in which metastases detection with positron emission tomography (PET) is problematic, could be achieved by using ferumoxtran compared to non-contrast-enhanced MR imaging [160, 161].”
From Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications (2019) · cites this paper as [160]
USPIO and contrast-enhanced MRI can distinguish micro-metastatic lymph nodes from healthy and inflammatory nodes more efficiently than standard size-based staging.
“By using USPIO and contrast-enhanced MRI, micro-metastatic lymph nodes can be distinguished much more efficiently from healthy and inflammatory nodes [161].”
From Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications (2019) · cites this paper as [161]
Cites
The Measurement of Observer Agreement for Categorical Data
Landis, J. R., & Koch, G. G. (1977) · Biometrics · doi:10.2307/2529310 · Cited by 81,148 · see citing works
Beneficial Effect of Carotid Endarterectomy in Symptomatic Patients with High-Grade Carotid Stenosis
(1991) · New England Journal of Medicine · doi:10.1056/nejm199108153250701 · Cited by 8,368 · see citing works
Stary, H. C., Chandler, A. B., Dinsmore, R. E., Fuster, V., Glagov, S. K., Insull, W., Rosenfeld, M. E., Schwartz, C. J., Wagner, W. D., & Wissler, R. W. (1995) · Circulation · doi:10.1161/01.cir.92.5.1355 · Cited by 3,506 · see citing works
Greenlee, R. T., Hill-Harmon, M. B., Murray, T., & Thun, M. J. (2001) · CA A Cancer Journal for Clinicians · doi:10.3322/canjclin.51.1.15 · Cited by 3,281 · see citing works
Lewin, M., Carlesso, N., Tung, C., Tang, X. S., Cory, D. G., Scadden, D. T., & Weissleder, R. (2000) · Nature Biotechnology · doi:10.1038/74464 · Cited by 1,716 · see citing works
Self-citationROC Methodology in Radiologic Imaging
Metz, C. E. (1986) · Investigative Radiology · doi:10.1097/00004424-198609000-00009 · Cited by 1,628 · see citing works
Bolla, M., González, D., Warde, P. R., Dubois, J. B., Mirimanoff, R., Storme, G. A., Bernier, J., Kuten, A., Sternberg, C. N., Gil, T., et al. (1997) · New England Journal of Medicine · doi:10.1056/nejm199707313370502 · Cited by 1,547 · see citing works
Messing, E. M., Manola, J. B., Sarosdy, M., Wilding, G., Crawford, E. D., & Trump, D. L. (1999) · New England Journal of Medicine · doi:10.1056/nejm199912093412401 · Cited by 1,189 · see citing works
Magnetic relaxation switches capable of sensing molecular interactions
Pérez, J. M. S., Josephson, L., O'Loughlin, T., Högemann, D., & Weissleder, R. (2002) · Nature Biotechnology · doi:10.1038/nbt720 · Cited by 889 · see citing works
Self-citationBilateral orchiectomy with or without flutamide for metastatic prostate cancer.
Eisenberger, M. A., Blumenstein, B. A., Crawford, E. D., Miller, G., McLeod, D. G., Loehrer, P. J., Wilding, G., Sears, K., Culkin, D. J., Thompson, I. M., et al. (1998) · New England Journal of Medicine · doi:10.1056/nejm199810083391504 · Cited by 859 · see citing works
Variations in Morbidity after Radical Prostatectomy
Begg, C. B., Riedel, E., Bach, P. B., Kattan, M. W., Schrag, D., Warren, J. L., & Scardino, P. T. (2002) · New England Journal of Medicine · doi:10.1056/nejmsa011788 · Cited by 839 · see citing works
A Randomized Trial Comparing Radical Prostatectomy with Watchful Waiting in Early Prostate Cancer
Holmberg, L., Bill‐Axelson, A., Helgesen, F., Salo, J. O., Folmerz, P., Häggman, M., Andersson, S., Spångberg, A., Busch, C., Nordling, S., et al. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa012794 · Cited by 809 · see citing works
In vivo magnetic resonance imaging of transgene expression
Weissleder, R., Moore, A. V., Mahmood, U., Bhorade, R. M., Benveniste, H., Chiocca, E. A., & Basilion, J. P. (2000) · Nature Medicine · doi:10.1038/73219 · Cited by 776 · see citing works
Self-citationPamidronate to Prevent Bone Loss during Androgen-Deprivation Therapy for Prostate Cancer
Smith, M. R., McGovern, F. J., Zietman, A. L., Fallon, M. A., Hayden, D. L., Schoenfeld, D., Kantoff, P. W., & Finkelstein, J. S. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa010845 · Cited by 695 · see citing works
Ruehm, S. G., Corot, C., VOGT, P. R., Kolb, S., & Debatin, J. F. (2001) · Circulation · doi:10.1161/01.cir.103.3.415 · Cited by 600 · see citing works
Monocrystalline iron oxide nanocompounds (MION): Physicochemical properties
Shen, T. T., Weissleder, R., Papisov, M. I., Bogdanov, A. A., Jr., & Brady, T. J. (1993) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910290504 · Cited by 496 · see citing works
Self-citationWeissleder, R., Elizondo, G., WITTENBERG, J., Lee, A. S., Josephson, L., & Brady, T. J. (1990) · Radiology · doi:10.1148/radiology.175.2.2326475 · Cited by 491 · see citing works
Self-citationIn Vivo Detection of Macrophages in Human Carotid Atheroma
Trivedi, R. A., U-King-Im, J.-M., Graves, M. J., Cross, J., Horsley, J., Goddard, M. J., Skepper, J. N., Quartey, G., Warburton, E. A., Joubert, I., et al. (2004) · Stroke · doi:10.1161/01.str.0000131268.50418.b7 · Cited by 300 · see citing works
Clinical Utility of Proton Magnetic Resonance Spectroscopy in Characterizing Breast Lesions
Katz‐Brull, R. (2002) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/94.16.1197 · Cited by 268 · see citing works
Jager, G. J., Barentsz, J. O., Oosterhof, G. O. N., Witjes, J. A., & Ruijs, S. H. J. (1996) · American Journal of Roentgenology · doi:10.2214/ajr.167.6.8956585 · Cited by 256 · see citing works
Self-citationProstatic carcinoma: staging by clinical assessment, CT, and MR imaging.
Hricak, H., Dooms, G., Jeffrey, R. B., Avallone, A. N., Jacobs, D., Benton, W. K., Narayan, P. A., & Tanagho, E. A. (1987) · Radiology · doi:10.1148/radiology.162.2.3797645 · Cited by 243 · see citing works
Billotey, C., Wilhelm, C., Devaud, M., Bacri, J.-C., Bittoun, J., & Gazeau, F. (2003) · Magnetic Resonance in Medicine · doi:10.1002/mrm.10418 · Cited by 233 · see citing works
Corot, C., Petry, K. G., Trivedi, R. A., Saleh, A., Jonkmanns, C., Bas, J. L., Blezer, E. L. A., Rausch, M., Brochet, B., Foster‐Gareau, P., et al. (2004) · Investigative Radiology · doi:10.1097/01.rli.0000135980.08491.33 · Cited by 229 · see citing works
Anzai, Y., Blackwell, K. E., Hirschowitz, S. L., Rogers, J. W., Satō, Y., Yuh, W. T. C., Runge, V. M., Morris, M. R., McLachlan, S. J., & Lufkin, R. B. (1994) · Radiology · doi:10.1148/radiology.192.3.7520182 · Cited by 218 · see citing works
Michel, S. C. A., Keller, T. M., Froehlich, J. M., Fink, D. A., Caduff, R. F., Seifert, B., Marinček, B., & Huch, R. (2002) · Radiology · doi:10.1148/radiol.2252011605 · Cited by 204 · see citing works
Harisinghani, M. G., Saini, S., Weissleder, R., Hahn, P. F., Yantiss, R. K., Tempany, C. M., Wood, B. J., & Müeller, P. R. (1999) · American Journal of Roentgenology · doi:10.2214/ajr.172.5.10227514 · Cited by 173 · see citing works
Self-citationTHE PROSTATE: MR IMAGING AND SPECTROSCOPY
Kurhanewicz, J. V., Vigneron, D. B., Males, R. G., Swanson, M. G., Yu, K. K., & Hricak, H. (2000) · Radiologic Clinics of North America · doi:10.1016/s0033-8389(05)70152-4 · Cited by 172 · see citing works
Visualization of Prostate Cancer with 11C-Choline Positron Emission Tomography
de Jong, I. J., Pruim, J., Elsinga, P. H., Vaalburg, W., & Mensink, H. J. A. (2002) · European Urology · doi:10.1016/s0302-2838(02)00129-x · Cited by 157 · see citing works
Advances in Biomedical Imaging
Tempany, C. M. (2001) · JAMA · doi:10.1001/jama.285.5.562 · Cited by 154 · see citing works
Cancer Volume of Lymph Node Metastasis Predicts Progression in Prostate Cancer
Liang Cheng, C., Bergstralh, E. J., Cheville, J. C., Slezak, J. M., Corica, F. A., Zincke, H., Blute, M. L., & Bostwick, D. G. (1998) · The American Journal of Surgical Pathology · doi:10.1097/00000478-199812000-00006 · Cited by 132 · see citing works
Open pelvic lymph node dissection for prostate cancer: a reassessment
Campbell, S. C., Klein, E. A., Levin, H. S., & PIEDMONTE, M. R. (1995) · Urology · doi:10.1016/s0090-4295(99)80219-2 · Cited by 92 · see citing works
MR imaging of mediastinal lymph nodes: Evaluation using a superparamagnetic contrast agent
Pannu, H. K., Wang, K.-P., Borman, T. L., & Bluemke, D. A. (2000) · Journal of Magnetic Resonance Imaging · doi:10.1002/1522-2586(200012)12:6 · Cited by 84 · see citing works
Detection of lymph node metastases by contrast‐enhanced MRI in an experimental model
Wunderbaldinger, P., Josephson, L., Bremer, C., Moore, A. V., & Weissleder, R. (2002) · Magnetic Resonance in Medicine · doi:10.1002/mrm.10068 · Cited by 80 · see citing works
Self-citationSurgery and the Reduction of Mortality from Prostate Cancer
Walsh, P. C. (2002) · New England Journal of Medicine · doi:10.1056/nejme020089 · Cited by 71 · see citing works
Axillary lymph node metastases: A statistical analysis of various parameters in MRI with USPIO
Stets, C., Brandt, S., Wallis, F., Buchmann, J., Gilbert, F. J., & Heywang-Köbrunner, S. H. (2002) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.10134 · Cited by 70 · see citing works
INDICATIONS FOR PELVIC LYMPHADENECTOMY IN PROSTATE CANCER
Link, R. E., & Morton, R. A. (2001) · Urologic Clinics of North America · doi:10.1016/s0094-0143(05)70157-9 · Cited by 61 · see citing works
Prostate cancer schemes for androgen escape
Brinkmann, A. O., & Trapman, J. (2000) · Nature Medicine · doi:10.1038/76194 · Cited by 60 · see citing works
Kothari, P. S., Scardino, P. T., Ohori, M., Kattan, M. W., & Wheeler, T. M. (2001) · The American Journal of Surgical Pathology · doi:10.1097/00000478-200111000-00012 · Cited by 59 · see citing works
MRI-Guided Diagnosis and Treatment of Prostate Cancer
D'Amico, A. V., Cormack, R. A., & Tempany, C. M. (2001) · New England Journal of Medicine · doi:10.1056/nejm200103083441017 · Cited by 37 · see citing works
Beissner, R. S., Stricker, J. B., Speights, V. O., Coffield, K. S., Spiekerman, A. M., & Riggs, M. W. (2002) · Urology · doi:10.1016/s0090-4295(02)01531-5 · Cited by 24 · see citing works
Imaging macrophage activity in the brain by using ultrasmall particles of iron oxide.
Bulte, J. W. M., & Frank, J. A. (2000) · PubMed Central · Cited by 16 · see citing works
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Self-Assembled Monolayers of Thiolates on Metals as a Form of Nanotechnology
Love, J. C., Estroff, L. A., Kriebel, J. K., Nuzzo, R. G., & Whitesides, G. M. (2005) · Chemical Reviews · doi:10.1021/cr0300789 · Cited by 8,279 · see citing works
Cancer nanotechnology: opportunities and challenges
Ferrari, M. (2005) · Nature Reviews Cancer · doi:10.1038/nrc1566 · Cited by 4,558 · see citing works
Nanomaterials and nanoparticles: Sources and toxicity
Buzea, C., Pacheco, I. I., & Robbie, K. (2007) · Biointerphases · doi:10.1116/1.2815690 · Cited by 3,789 · see citing works
Bertrand, N., Wu, J., Xu, X., Kamaly, N., & Farokhzad, O. C. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2013.11.009 · Cited by 2,865 · see citing works
Magnetic nanoparticles in MR imaging and drug delivery
Sun, C., Lee, J. S. H., & Zhang, M. (2008) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2008.03.018 · Cited by 2,595 · see citing works
Applications of Magnetic Nanoparticles in Biomedicine
Bárcena, C., Sra, A. K., & Gao, J. (2009) · Springer eBooks · doi:10.1007/978-0-387-85600-1_20 · Cited by 2,566 · see citing works
Imaging in the era of molecular oncology
Weissleder, R., & Pittet, M. J. (2008) · Nature · doi:10.1038/nature06917 · Cited by 2,365 · see citing works
Self-citationIn vivo tumor targeting and spectroscopic detection with surface-enhanced Raman nanoparticle tags
Qian, X., Peng, X.-H., Ansari, D. O., Yin-Goen, Q., Chen, G. Z., Shin, D. M., Yang, L., Young, A. N., Wang, M. D., & Nie, S. (2008) · Nature Biotechnology · doi:10.1038/nbt1377 · Cited by 2,201 · see citing works
Nanomedicine: current status and future prospects
Moghimi, S. M., Hunter, A. C., & Murray, J. C. (2005) · The FASEB Journal · doi:10.1096/fj.04-2747rev · Cited by 2,029 · see citing works
Design and fabrication of magnetic nanoparticles for targeted drug delivery and imaging
Omid Veiseh, A., Gunn, J., & Zhang, M. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.11.002 · Cited by 1,826 · see citing works
Inorganic Nanoparticles for MRI Contrast Agents
Na, H. B., Song, I. C., & Hyeon, T. (2009) · Advanced Materials · doi:10.1002/adma.200802366 · Cited by 1,776 · see citing works
Chemistry of MRI Contrast Agents: Current Challenges and New Frontiers
Wahsner, J., Gale, E. M., Rodríguez‐Rodríguez, A., & Caravan, P. D. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00363 · Cited by 1,615 · see citing works
Iron oxide MR contrast agents for molecular and cellular imaging
Bulte, J. W. M., & Kraitchman, D. L. (2004) · NMR in Biomedicine · doi:10.1002/nbm.924 · Cited by 1,500 · see citing works
Prabhakar, U., Maeda, H., Jain, R. K., Sevick-Muraca, E. M., Zamboni, W. C., Farokhzad, O. C., Barry, S. T., Gabizón, A., Grodzinski, P. A., & Blakey, D. C. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-4561 · Cited by 1,493 · see citing works
Recent advances in iron oxide nanocrystal technology for medical imaging☆
Corot, C., Robert, P., Idée, J., & Port, M. (2006) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2006.09.013 · Cited by 1,461 · see citing works
Nanoparticle-based theranostic agents
Xie, J., Lee, S., & Chen, X. S. (2010) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2010.07.009 · Cited by 1,423 · see citing works
Targeted drug delivery strategies for precision medicines
Manzari, M. T., Shamay, Y., Kiguchi, H., Rosen, N. X., Scaltriti, M., & Heller, D. A. (2021) · Nature Reviews Materials · doi:10.1038/s41578-020-00269-6 · Cited by 1,201 · see citing works
Bioconjugated quantum dots for in vivo molecular and cellular imaging☆
SMITH, A., Duan, H., Mohs, A. M., & Nie, S. (2008) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2008.03.015 · Cited by 1,196 · see citing works
Peeters, K. C. M. J., Marijnen, C. A. M., Nagtegaal, I. D., Kranenbarg, E. K., Putter, H., Wiggers, T., Rutten, H., Pahlman, L., Glimelius, B., Leer, J. W., et al. (2007) · Annals of Surgery · doi:10.1097/01.sla.0000257358.56863.ce · Cited by 1,191 · see citing works
Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications
Dadfar, S. M., Roemhild, K., Drude, N. I., von Stillfried, S., Knüchel, R., Kiessling, F., & Lammers, T. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2019.01.005 · Cited by 1,181 · see citing works
Treating metastatic cancer with nanotechnology
Schroeder, A., Heller, D. A., Winslow, M. M., Dahlman, J. E., Pratt, G. W., Langer, R., Jacks, T., & Anderson, D. G. (2011) · Nature reviews. Cancer · doi:10.1038/nrc3180 · Cited by 1,154 · see citing works
Kim, B. Y. S., Rutka, J. T., & Chan, W. C. W. (2010) · New England Journal of Medicine · doi:10.1056/nejmra0912273 · Cited by 1,153 · see citing works
Nanotechnology Applications in Cancer
Nie, S., Xing, Y., Gloria, K., & Simons, J. W. (2007) · Annual Review of Biomedical Engineering · doi:10.1146/annurev.bioeng.9.060906.152025 · Cited by 1,125 · see citing works
Weissleder, R. (2006) · Science · doi:10.1126/science.1125949 · Cited by 1,107 · see citing works
Self-citationNanomaterials for In Vivo Imaging
Smith, B. R., & Gambhir, S. S. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.6b00073 · Cited by 1,076 · see citing works
Gold nanoparticles as novel agents for cancer therapy
Jain, S., Hirst, D. G., & O’Sullivan, J. M. (2012) · British Journal of Radiology · doi:10.1259/bjr/59448833 · Cited by 1,070 · see citing works
Jia Liu, B., Sun, Z., Deng, Y., Zou, Y. Q., Li, C., Guo, X., Xiong, L., Gao, Y., Li, F., & Zhao, D. (2009) · Angewandte Chemie International Edition · doi:10.1002/anie.200901566 · Cited by 1,058 · see citing works
Kaufman, D. S., Shipley, W. U., & Feldman, A. S. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60491-8 · Cited by 1,025 · see citing works
Iron Oxide Based Nanoparticles for Multimodal Imaging and Magnetoresponsive Therapy
Lee, N., Yoo, D., Ling, D., Cho, M. H., Hyeon, T., & Cheon, J. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00112 · Cited by 1,007 · see citing works
Eiber, M. J., Maurer, T., Souvatzoglou, M., Beer, A. J., Ruffani, A., Haller, B., Graner, F.-P., Kübler, H. R., Haberhorn, U., Eisenhut, M., et al. (2015) · Journal of Nuclear Medicine · doi:10.2967/jnumed.115.154153 · Cited by 995 · see citing works
Hövels, A. M., Heesakkers, R. A. M., Adang, E., Jager, G. J., Strum, S. B., Hoogeveen, Y. L., Severens, J. L., & Barentsz, J. O. (2008) · Clinical Radiology · doi:10.1016/j.crad.2007.05.022 · Cited by 956 · see citing works
Self-citationCell-specific targeting of nanoparticles by multivalent attachment of small molecules
Weissleder, R., Kelly, K., Sun, E. Y., Shtatland, T., & Josephson, L. (2005) · Nature Biotechnology · doi:10.1038/nbt1159 · Cited by 898 · see citing works
Self-citationMultifunctional magnetic nanoparticles for targeted imaging and therapy
MCCARTHY, J., & WEISSLEDER, R. (2008) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2008.03.014 · Cited by 892 · see citing works
Self-citationHeidenreich, A., Joaquim Bellmunt, B., Bolla, M., Joniau, S., Matveev, V. B., Mottet, N., Wiegel, T., & Zattoni, F. (2013) · Cited by 869 · see citing works
Nanoscaling Laws of Magnetic Nanoparticles and Their Applicabilities in Biomedical Sciences
Jun, Y., Seo, J.-W., & Cheon, J. (2008) · Accounts of Chemical Research · doi:10.1021/ar700121f · Cited by 866 · see citing works
Silica-Coated Nanocomposites of Magnetic Nanoparticles and Quantum Dots
Yi, D. K., Selvan, S. T., Lee, S. S., Papaefthymiou, G. C., Kundaliya, D. C., & Ying, J. Y. (2005) · Journal of the American Chemical Society · doi:10.1021/ja0428863 · Cited by 849 · see citing works
The 'right' size in nanobiotechnology
Whitesides, G. M. (2003) · Nature Biotechnology · doi:10.1038/nbt872 · Cited by 847 · see citing works
Biomedical Nanomagnetics: A Spin Through Possibilities in Imaging, Diagnostics, and Therapy
Krishnan, K. M. (2010) · IEEE Transactions on Magnetics · doi:10.1109/tmag.2010.2046907 · Cited by 831 · see citing works
In vivo delivery, pharmacokinetics, biodistribution and toxicity of iron oxide nanoparticles
Arami, H., Khandhar, A., Liggitt, D., & Krishnan, K. M. (2015) · Chemical Society Reviews · doi:10.1039/c5cs00541h · Cited by 830 · see citing works
de Vries, I. J. M., Lesterhuis, W. J., Barentsz, J. O., Verdijk, P., van Krieken, J. H., Boerman, O. C., Oyen, W. J. G., Bonenkamp, J. J., Boezeman, J. B., Adema, G. J., et al. (2005) · Nature Biotechnology · doi:10.1038/nbt1154 · Cited by 821 · see citing works
Self-citationFass, L. (2008) · Molecular Oncology · doi:10.1016/j.molonc.2008.04.001 · Cited by 821 · see citing works
Imaging macrophages with nanoparticles
Weissleder, R., Nahrendorf, M., & Pittet, M. J. (2014) · Nature Materials · doi:10.1038/nmat3780 · Cited by 809 · see citing works
Self-citationKim, C., Favazza, C. P., & Wang, L. V. (2010) · Chemical Reviews · doi:10.1021/cr900266s · Cited by 807 · see citing works
Nanomedicine: Developing smarter therapeutic and diagnostic modalities☆
Farokhzad, O. C., & Langer, R. (2006) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2006.09.011 · Cited by 802 · see citing works
Clinical Translation of Nanomedicine
Min, Y., Caster, J. M., Eblan, M. J., & Wang, A. Z. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00116 · Cited by 795 · see citing works
Superparamagnetic Iron Oxide Nanoparticle Probes for Molecular Imaging
Thorek, D. L. J., Chen, A. K., Czupryna, J., & Tsourkas, A. (2006) · Annals of Biomedical Engineering · doi:10.1007/s10439-005-9002-7 · Cited by 770 · see citing works
Design considerations for tumour-targeted nanoparticles
Choi, H. S., Liu, W., Liu, F., Nasr, K., Misra, P., Bawendi, M. G., & Frangioni, J. V. (2010) · Nature Nanotechnology · doi:10.1038/nnano.2009.314 · Cited by 754 · see citing works
Advances in Magnetic Nanoparticles for Biomedical Applications
Cardoso, V. F., Francesko, A., Ribeiro, C., Bañobre‐López, M., Martins, P., & Lanceros-Méndez, S. (2017) · Advanced Healthcare Materials · doi:10.1002/adhm.201700845 · Cited by 727 · see citing works
Gupta, A. K., Naregalkar, R. R., Vaidya, V. D., & Gupta, M. (2007) · Nanomedicine · doi:10.2217/17435889.2.1.23 · Cited by 708 · see citing works
Surface-Charge-Dependent Cell Localization and Cytotoxicity of Cerium Oxide Nanoparticles
Asati, A., Santra, S., Kaittanis, C., & Perez, J. M. (2010) · ACS Nano · doi:10.1021/nn100816s · Cited by 702 · see citing works
Application of Nanotechnology in Cancer Therapy and Imaging
Wang, X., Yang, L., Chen, Z., & Shin, D. M. (2008) · CA A Cancer Journal for Clinicians · doi:10.3322/ca.2007.0003 · Cited by 696 · see citing works
Superparamagnetic iron oxide nanoparticles: from preparations to in vivo MRI applications
Qiao, R., Yang, C., & Gao, M. (2009) · Journal of Materials Chemistry · doi:10.1039/b902394a · Cited by 685 · see citing works
Toxicology and clinical potential of nanoparticles
Yildirimer, L., Thanh, N. T. K., Loizidou, M., & Seifalian, A. M. (2011) · Nano Today · doi:10.1016/j.nantod.2011.10.001 · Cited by 675 · see citing works
Semiconductor Quantum Dots for Bioimaging and Biodiagnostic Applications
Kairdolf, B. A., Smith, A. M., Stokes, T. H., Wang, M. D., Young, A. N., & Nie, S. (2013) · Annual Review of Analytical Chemistry · doi:10.1146/annurev-anchem-060908-155136 · Cited by 674 · see citing works
Progress and Promise of FDG-PET Imaging for Cancer Patient Management and Oncologic Drug Development
Kelloff, G. J., Hoffman, J. M., Johnson, B. E., Scher, H. I., Siegel, B. A., Cheng, E. Y., Cheson, B. D., O’Shaughnessy, J., Guyton, K. Z., Mankoff, D. A., et al. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-2626 · Cited by 672 · see citing works
Tassa, C., Shaw, S. Y., & Weissleder, R. (2011) · Accounts of Chemical Research · doi:10.1021/ar200084x · Cited by 653 · see citing works
Self-citationNanotechnology for the biologist
McNeil, S. E. (2005) · Journal of Leukocyte Biology · doi:10.1189/jlb.0205074 · Cited by 622 · see citing works
Liu, Y., Miyoshi, H., & Nakamura, M. (2007) · International Journal of Cancer · doi:10.1002/ijc.22709 · Cited by 620 · see citing works
Inorganic nanoparticles for cancer imaging and therapy
Huang, H., Barua, S., Sharma, G., Dey, S. K., & Rege, K. (2011) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.06.004 · Cited by 620 · see citing works
Development of a T1 Contrast Agent for Magnetic Resonance Imaging Using MnO Nanoparticles
Na, H. B., Lee, J. H., An, K., Park, Y. I., Park, M., Lee, I. S., Nam, D., Kim, S. T., Kim, S., Kim, S., et al. (2007) · Angewandte Chemie International Edition · doi:10.1002/anie.200604775 · Cited by 615 · see citing works
Nahrendorf, M., Jaffer, F. A., Kelly, K. A., Sosnovik, D. E., Aikawa, E., Libby, P., & Weissleder, R. (2006) · Circulation · doi:10.1161/circulationaha.106.646380 · Cited by 602 · see citing works
Self-citationImaging Prostate Cancer: A Multidisciplinary Perspective
Hricak, H., Choyke, P. L., Eberhardt, S. C., Leibel, S. A., & Scardino, P. T. (2007) · Radiology · doi:10.1148/radiol.2431030580 · Cited by 592 · see citing works
Applications and potential toxicity of magnetic iron oxide nanoparticles
Liu, G., Gao, J., Ai, H., & Chen, X. (2013) · Small · doi:10.1002/smll.201201531 · Cited by 570 · see citing works
Molecular imaging: current status and emerging strategies
Pysz, M. A., Gambhir, S. S., & Willmann, J. K. (2010) · Clinical Radiology · doi:10.1016/j.crad.2010.03.011 · Cited by 570 · see citing works
Nucleic Acid Based Molecular Devices
Krishnan, Y., & Simmel, F. C. (2011) · Angewandte Chemie International Edition · doi:10.1002/anie.200907223 · Cited by 569 · see citing works
Nanoplatforms for Targeted Molecular Imaging in Living Subjects
Cai, W., & Chen, X. S. (2007) · Small · doi:10.1002/smll.200700351 · Cited by 564 · see citing works
Nanoparticle PET-CT Imaging of Macrophages in Inflammatory Atherosclerosis
Nahrendorf, M., Zhang, H., Hembrador, S., Panizzi, P., Sosnovik, D. E., Aikawa, E., Libby, P., Swirski, F. K., & Weissleder, R. (2008) · Circulation · doi:10.1161/circulationaha.107.741181 · Cited by 559 · see citing works
Self-citationMagnetic Iron Oxide Nanoworms for Tumor Targeting and Imaging
Park, J., von Maltzahn, G., Zhang, L., Schwartz, M. P., Ruoslahti, E. I., Bhatia, S. N., & Sailor, M. J. (2008) · Advanced Materials · doi:10.1002/adma.200800004 · Cited by 555 · see citing works
Magnetic nanoparticle biosensors
Haun, J. B., Yoon, T., Lee, H., & Weissleder, R. (2010) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.84 · Cited by 554 · see citing works
Self-citationOptical coherence tomography: a review of clinical development from bench to bedside
Zysk, A. M., Nguyen, F. T., Oldenburg, A. L., Marks, D. L., & Boppart, S. A. (2007) · Journal of Biomedical Optics · doi:10.1117/1.2793736 · Cited by 543 · see citing works
Multifunctional Nanoparticles for Drug Delivery and Molecular Imaging
Bao, G., Mitragotri, S., & Tong, S. (2013) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-071812-152409 · Cited by 537 · see citing works
Leuschner, F., Rauch, P. J., Ueno, T., Gorbatov, R., Marinelli, B. S., Lee, W. W., Dutta, P., Wei, Y., Robbins, C. S., Iwamoto, Y., et al. (2012) · The Journal of Experimental Medicine · doi:10.1084/jem.20111009 · Cited by 519 · see citing works
Self-citationTissue invasion and metastasis: Molecular, biological and clinical perspectives
Jiang, W. G., Sanders, A. J., Katoh, M., Ungefroren, H., Gieseler, F., Prince, M. E., Thompson, S. K., Zollo, M., Spano, D., Dhawan, P., et al. (2015) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2015.03.008 · Cited by 514 · see citing works
Pelvic Lymph Node Dissection in Prostate Cancer
Briganti, A., Blute, M. L., Eastham, J. H., Graefen, M., Heidenreich, A., Karnes, J. R., Montorsi, F., & Studer, U. E. (2009) · European Urology · doi:10.1016/j.eururo.2009.03.012 · Cited by 507 · see citing works
Polymeric nanomedicine for cancer therapy
Park, J. H., Lee, S., Kim, J.-H., Park, K., Kim, K., & Kwon, I. C. (2008) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2007.09.003 · Cited by 506 · see citing works
Noninvasive cell-tracking methods
Kircher, M. F., Gambhir, S. S., & Grimm, J. (2011) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2011.141 · Cited by 504 · see citing works
Prostate Specific Antigen Best Practice Statement: 2009 Update
Greene, K. L., Albertsen, P. C., Babaian, R. J., Carter, H. B., Gann, P. H., Han, M., Kuban, D. A., Sartor, O. A., Stanford, J. L., Zietman, A. L., et al. (2009) · The Journal of Urology · doi:10.1016/j.juro.2009.07.093 · Cited by 503 · see citing works
Nanoparticles: Taking a Unique Position in Medicine
Joseph, T. M., Mahapatra, D. K., Esmaeili, A., Piszczyk, Ł., Hasanin, M. S., Kattali, M., Haponiuk, J. T., & Thomas, S. (2023) · Nanomaterials · doi:10.3390/nano13030574 · Cited by 502 · see citing works
Cancer Theranostics with Near-Infrared Light-Activatable Multimodal Nanoparticles
Melancon, M. P., Zhou, M., & Li, C. (2011) · Accounts of Chemical Research · doi:10.1021/ar200022e · Cited by 501 · see citing works
Applications of nanoparticles for diagnosis and therapy of cancer
Baetke, S. C., Lammers, T., & Kiessling, F. M. (2015) · British Journal of Radiology · doi:10.1259/bjr.20150207 · Cited by 499 · see citing works
Kim, J., Lee, J. E., Lee, S. H., Yu, J. H., Lee, J. H., Park, T. G., & Hyeon, T. (2008) · Advanced Materials · doi:10.1002/adma.200701726 · Cited by 494 · see citing works
Exceedingly small iron oxide nanoparticles as positive MRI contrast agents
Wei, H., Bruns†, O. T., Kaul, M. G., Hansen, E. C., Barch, M., Wiśniowska, A. E., Chen, O., Chen, Y., Li, N., Okada, S., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1620145114 · Cited by 491 · see citing works
Nanowire Sensors for Medicine and The Life Sciences
Patolsky, F., Zheng, G., & Lieber, C. M. (2006) · Nanomedicine · doi:10.2217/17435889.1.1.51 · Cited by 489 · see citing works
Tracking immune cells in vivo using magnetic resonance imaging
Ahrens, E. T., & Bulte, J. W. M. (2013) · Nature reviews. Immunology · doi:10.1038/nri3531 · Cited by 488 · see citing works
Nanoparticles in modern medicine: state of the art and future challenges.
(2007) · PubMed Central · Cited by 484 · see citing works
Zhao, Z., Zhou, Z., Bao, J., Wang, Z., Hu, J., Chi, X., Ni, K., Wang, R., Chen, X. S., Chen, Z., et al. (2013) · Nature Communications · doi:10.1038/ncomms3266 · Cited by 481 · see citing works
Potential Toxicity of Iron Oxide Magnetic Nanoparticles: A Review
Malhotra, N., Lee, J., Liman, R. A. D., Ruallo, J. M. S., Villaflores, O. B., Ger, T.-R., & Hsiao, C. (2020) · Molecules · doi:10.3390/molecules25143159 · Cited by 477 · see citing works
Shin, J., Anisur, R. M., Ko, M. K., Im, G. H., Lee, J. H., & Lee, I. S. (2008) · Angewandte Chemie International Edition · doi:10.1002/anie.200802323 · Cited by 476 · see citing works
Emerging implications of nanotechnology on cancer diagnostics and therapeutics
Cuenca, A. G., Jiang, H., Hochwald, S. N., Delano, M. J., Cance, W. G., & Grobmyer, S. R. (2006) · Cancer · doi:10.1002/cncr.22035 · Cited by 473 · see citing works
Nanoparticle-Based Immunotherapy for Cancer
Shao, K., Singha, S., Clemente‐Casares, X., Tsai, S. J., Yang, Y., & Santamaría, P. (2014) · ACS Nano · doi:10.1021/nn5062029 · Cited by 472 · see citing works
Targeted magnetic iron oxide nanoparticles for tumor imaging and therapy
Shin, D. (2008) · International Journal of Nanomedicine · doi:10.2147/ijn.s2824 · Cited by 463 · see citing works
Detection of Vascular Adhesion Molecule-1 Expression Using a Novel Multimodal Nanoparticle
Kelly, K. A., Allport, J. R., Tsourkas, A., Patil, V. R. S., Josephson, L., & Weissleder, R. (2005) · Circulation Research · doi:10.1161/01.res.0000155722.17881.dd · Cited by 448 · see citing works
Self-citationMagnetite nanoparticles for medical MR imaging
Stephen, Z. R., Kievit, F. M., & Zhang, M. (2011) · Materials Today · doi:10.1016/s1369-7021(11)70163-8 · Cited by 430 · see citing works
Magnetic nanoparticle-based drug delivery for cancer therapy
Tietze, R., Zaloga, J., Unterweger, H., Lyer, S., Friedrich, R. P., Janko, C., Pöttler, M., Dürr, S., & Alexiou, C. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.08.022 · Cited by 425 · see citing works
Yang, W., Guo, W., Le, W., Lv, G., Zhang, F., Shi, L., Wang, X., Wang, J., Wang, S., Chang, J. K., et al. (2016) · ACS Nano · doi:10.1021/acsnano.6b05760 · Cited by 410 · see citing works
Proton-Sponge Coated Quantum Dots for siRNA Delivery and Intracellular Imaging
Yezhelyev, M. V., Qi, L., O'Regan, R. M., Nie, S., & Gao, X. (2008) · Journal of the American Chemical Society · doi:10.1021/ja800086u · Cited by 406 · see citing works
Nanocarriers-Mediated Drug Delivery Systems for Anticancer Agents: An Overview and Perspectives
Edis, Z., Wang, J., Waqas, M. K., Ijaz, M., & Ijaz, M. (2021) · International Journal of Nanomedicine · doi:10.2147/ijn.s289443 · Cited by 403 · see citing works
Macrophage Endocytosis of Superparamagnetic Iron Oxide Nanoparticles
Raynal, I., Prigent, P., Peyramaure, S., Najid, A., Rebuzzi, C., & Corot, C. (2003) · Investigative Radiology · doi:10.1097/01.rli.0000101027.57021.28 · Cited by 402 · see citing works
Park, Y. I., Kim, H. M., Kim, J. H., Moon, K., Yoo, B., Lee, K. T., Lee, N., Choi, Y., Park, W., Ling, D., et al. (2012) · Advanced Materials · doi:10.1002/adma.201202433 · Cited by 398 · see citing works
Synthesis of Biocompatible Dextran‐Coated Nanoceria with pH‐Dependent Antioxidant Properties
Perez, J. M., Asati, A., Nath, S., & Kaittanis, C. (2008) · Small · doi:10.1002/smll.200700824 · Cited by 397 · see citing works
- Authors
- Harisinghani, M. G., Barentsz, J., Hahn, P. F., Deserno, W. M., Tabatabaei, S., van de Kaa, C. H., de la Rosette, J., & Weissleder, R.
- Affiliations
- Harvard University (US)
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2003-06-19
- Volume
- 348
- Issue
- 25
- Pages
- 2491-2499
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2116810900
- Cited by
- 1,971
- References
- 42
- Citations by year
- 2026: 13 · 2025: 15 · 2024: 34 · 2023: 42 · 2022: 54 · 2021: 49 · 2020: 59 · 2019: 50 · 2018: 66 · 2017: 82 · 2016: 83 · 2015: 94 · 2014: 95 · 2013: 120 · 2012: 129
- FWCI
- 81.09
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Funders
- National Institutes of Health (5r01ca059649-07)
- National Cancer Institute (R01-CA59649)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Prostate Cancer Diagnosis and Treatment
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › MRI in cancer diagnosis
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
- Keywords
- prostate cancer, lymph node metastasis, superparamagnetic iron oxide nanoparticles, magnetic resonance imaging, non-invasive detection, lymphatic drainage, diagnostic sensitivity
- MeSH terms
- Aged, Biopsy, Contrast Media, Ferric Compounds, Humans, Image Processing, Computer-Assisted, Lymph Nodes, Lymphatic Metastasis, Magnetic Resonance Imaging, Magnetics, Male, Middle Aged, Neoplasm Staging, Particle Size, Prospective Studies, Prostatic Neoplasms, Sensitivity and Specificity, Nanotechnology
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