The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
The Neurobiology of Cocaine Addiction
Open accessAbstract
Cocaine produces its psychoactive and addictive effects primarily by acting on the brain's limbic system, a set of interconnected regions that regulate pleasure and motivation. An initial, short-term effect -- a buildup of the neurochemical dopamine -- gives rise to euphoria and a desire to take the drug again. Researchers are seeking to understand how cocaine's many longer term effects produce addiction's persistent cravings and risk of relapse. In the author's laboratory, work has focused on buildup of the genetic transcription factor DeltaFosB. Levels of DeltaFosB in the limbic system correlate with addiction-like behaviors in mice and may precipitate very long-lasting changes to nerve cell structure. Further pursuit of this and similar leads are first steps toward a complete understanding of the transition from cocaine abuse to addiction -- and, ultimately, more effective treatments for those who are addicted.
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“The induction of behavioral locomotor sensitization in response to cocaine depends on the structural plasticity of MSNs and is associated with lasting changes in MSN spine density32.”
From Epigenetic regulation of brain region-specific microglia clearance activity (2018) · cites this paper as [32]
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Cites
Molecular basis of long-term plasticity underlying addiction
Nestler, E. J. (2001) · Nature reviews. Neuroscience · doi:10.1038/35053570 · Cited by 1,893
Self-citationIncentive-sensitization and addiction
Robinson, T. E., & Berridge, K. C. (2001) · Addiction · doi:10.1046/j.1360-0443.2001.9611038.x · Cited by 1,435
Addiction and the brain: The neurobiology of compulsion and its persistence
Hyman, S. E., & Malenka, R. C. (2001) · Nature reviews. Neuroscience · doi:10.1038/35094560 · Cited by 1,337
Koob, G. F., Sanna, P. P., & Bloom, F. E. (1998) · Neuron · doi:10.1016/s0896-6273(00)80557-7 · Cited by 1,026
The addicted human brain: insights from imaging studies
Volkow, N. D., Fowler, J. S., & Wang, G.-J. (2003) · Journal of Clinical Investigation · doi:10.1172/jci18533 · Cited by 916
ΔFosB: A sustained molecular switch for addiction
Nestler, E. J., Barrot, M., & Self, D. W. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.191352698 · Cited by 640 · cited 3×
“• Once created, a molecule of ΔFosB lasts for 6 to 8 weeks before breaking apart chemically (Nestler, Barrot, and Self, 2001).”
BackgroundSelf-citationRegulation of gene expression and cocaine reward by CREB and ΔFosB
McClung, C. A., & Nestler, E. J. (2003) · Nature Neuroscience · doi:10.1038/nn1143 · Cited by 625
Self-citationBrain circuitry and the reinstatement of cocaine-seeking behavior
Kalivas, P., & McFarland, K. (2003) · Psychopharmacology · doi:10.1007/s00213-003-1393-2 · Cited by 613
ΔFosB: a molecular switch for long-term adaptation in the brain
McClung, C. A., Ulery, P. G., Perrotti, L. I., Zachariou, V., Berton, O., & Nestler, E. J. (2004) · Molecular Brain Research · doi:10.1016/j.molbrainres.2004.05.014 · Cited by 409
Self-citationNestler, E. J., & Malenka, R. C. (2004) · Scientific American · doi:10.1038/scientificamerican0304-78 · Cited by 172
Self-citationResearch Advances in the Understanding and Treatment of Addiction
O’Brien, C. P. (2003) · American Journal on Addictions · doi:10.1111/j.1521-0391.2003.tb00555.x · Cited by 75
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Research works printed but not linked: 1
- Goldstein A 2001 Addiction: From Biology to Drug Policy 2nd ed Oxford Oxford University Press
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Lopez‐Quintero, C., Cobos, J. P. D. L., Hasin, D. S., Okuda, M., Wang, S., Grant, B. F., & Blanco, C. (2010) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2010.11.004 · Cited by 733
Epigenetic regulation of brain region-specific microglia clearance activity
Ayata, P., Badimon, A., Strasburger, H. J., Duff, M. K., Montgomery, S. E., Loh, Y.-H. E., Ebert, A., Pimenova, A. A., Ramirez, B. R., Chan, A. T., et al. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0192-3 · Cited by 460
Goodman, A. (2007) · Biochemical Pharmacology · doi:10.1016/j.bcp.2007.07.030 · Cited by 445
Targeting voltage-gated calcium channels in neurological and psychiatric diseases
Zamponi, G. W. (2015) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2015.5 · Cited by 374
Voices from within: gut microbes and the CNS
Forsythe, P., & Kunze, W. A. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1028-z · Cited by 336
Metadata
- Authors
- Nestler, E.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Corresponding author
- Nestler, Eric
- ORCID
- Nestler, Eric
- Venue
- Science & Practice Perspectives
- Publisher
- NIDA/RTI International
- Published
- 2005-12
- Volume
- 3
- Issue
- 1
- Pages
- 4-10
- ISSN
- 1930-4307 (ISSN-L)
- 1930-4315
- PMC
- PMC2851032
- OpenAlex
- W2037400076
- Cited by
- 367
- References
- 11
- Citations by year
- 2026: 13 · 2025: 21 · 2024: 31 · 2023: 25 · 2022: 17 · 2021: 28 · 2020: 67 · 2019: 19 · 2018: 18 · 2017: 6 · 2016: 22 · 2015: 19 · 2014: 10 · 2013: 13 · 2012: 17
- FWCI
- 0.60
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science & Practice Perspectives (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Drug Abuse (K05 DA 00404, K05DA000404, P01DA08227, R37 DA 07359, R37DA007359, P01DA008227)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Keywords
- cocaine dependence, limbic system, dopamine, ΔFosB, transcription factors, addiction-like behavior, relapse, neuroplasticity, drug craving, addiction treatment
- MeSH terms
- Gene Expression Regulation, Humans, Limbic System, Models, Neurological, Behavior, Addictive, Proto-Oncogene Proteins c-fos, Cocaine-Related Disorders
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