Regulation of gene expression and cocaine reward by CREB and ΔFosB

Neurobiology of Depression

Nestler, E. J., Barrot, M., DiLeone, R. J., Eisch, A. J., Gold, S. J., & Monteggia, L. M. (2002) · Neuron · doi:10.1016/s0896-6273(02)00653-0 · Cited by 3,217 · see citing works

Transcriptional regulation by the phosphorylation-dependent factor CREB

Mayr, B., & Montminy, M. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35085068 · Cited by 2,587 · see citing works

Function and regulation of CREB family transcription factors in the nervous system

Lonze, B. E., & Ginty, D. D. (2002) · Neuron · doi:10.1016/s0896-6273(02)00828-0 · Cited by 2,127 · see citing works

Molecular basis of long-term plasticity underlying addiction

Nestler, E. J. (2001) · Nature reviews. Neuroscience · doi:10.1038/35053570 · Cited by 1,857 · see citing works

Addiction, Dopamine, and the Molecular Mechanisms of Memory

Berke, J. D., & Hyman, S. E. (2000) · Neuron · doi:10.1016/s0896-6273(00)81056-9 · Cited by 1,167 · see citing works

Regulation of cocaine reward by CREB

Carlezon, W. A., Thome, J., Olson, V. G., Lane-Ladd, S. B., Brodkin, E. S., Hiroi, N., Duman, R. S., Neve, R. L., & Nestler, E. J. (1998) · Science · doi:10.1126/science.282.5397.2272 · Cited by 767 · see citing works

Expression of the transcription factor ΔFosB in the brain controls sensitivity to cocaine

Kelz, M. B., Chen, J., Carlezon, W. A., Whisler, K., Gilden, L., Beckmann, A. M., Steffen, C., Zhang, Y.-J., Marotti, L., Self, D. W., et al. (1999) · Nature · doi:10.1038/45790 · Cited by 641 · see citing works

ΔFosB: A sustained molecular switch for addiction

Nestler, E. J., Barrot, M., & Self, D. W. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.191352698 · Cited by 640 · cited 1× · see citing works

Induction of a long-lasting AP-1 complex composed of altered Fos-like proteins in brain by chronic cocaine and other chronic treatments

Hope, B. T., Nye, H. E., Kelz, M. B., Self, D. W., Iadarola, M. J., Nakabeppu, Y., Duman, R. S., & Nestler, E. J. (1994) · Neuron · doi:10.1016/0896-6273(94)90061-2 · Cited by 563 · see citing works

A general role for adaptations in G-proteins and the cyclic AMP system in mediating the chronic actions of morphine and cocaine on neuronal function

Terwilliger, R. Z., Beitner‐Johnson, D., Sevarino, K. A., Crain, S. M., & Nestler, E. J. (1991) · Brain Research · doi:10.1016/0006-8993(91)91111-d · Cited by 534 · see citing works

Stimulation of cAMP response element (CRE)-mediated transcription during contextual learning

Impey, S., Smith, D. M., Obrietan, K. H., Donahue, R. J., Wade, C. B., & Storm, D. R. (1998) · Nature Neuroscience · doi:10.1038/2830 · Cited by 520 · see citing works

Altered Responsiveness to Cocaine and Increased Immobility in the Forced Swim Test Associated with Elevated cAMP Response Element-Binding Protein Expression in Nucleus Accumbens

Pliakas, A. M., Carlson, R. R., Neve, R. L., Konradi, C., Nestler, E. J., & Carlezon, W. A. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-18-07397.2001 · Cited by 509 · see citing works

CREB activity in the nucleus accumbens shell controls gating of behavioral responses to emotional stimuli

Barrot, M., Olivier, J. D. A., Perrotti, L. I., DiLeone, R. J., Berton, O., Eisch, A. J., Impey, S., Storm, D. R., Neve, R. L., Yin, J. C., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.172091899 · Cited by 508 · see citing works

Effects of chronic exposure to cocaine are regulated by the neuronal protein Cdk5

Bibb, J. A., Chen, J., Taylor, J. R., Svenningsson, P., Nishi, A., Snyder, G. L., Yan, Z., Sagawa, Z. K., Ouimet, C. C., Nairn, A. C., et al. (2001) · Nature · doi:10.1038/35066591 · Cited by 480 · see citing works

The EGR family of transcription-regulatory factors: progress at the interface of molecular and systems neuroscience

O’Donovan, K. J., Tourtellotte, W. G., Milbrandt, J., & Baraban, J. M. (1999) · Trends in Neurosciences · doi:10.1016/s0166-2236(98)01343-5 · Cited by 457 · see citing works

A naturally occurring truncated form of FosB that inhibits Fos/Jun transcriptional activity

Nakabeppu, Y., & Nathans, D. (1991) · Cell · doi:10.1016/0092-8674(91)90504-r · Cited by 430 · see citing works

CREB and the formation of long-term memory

Yin, J. C. P., & Tully, T. P. (1996) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(96)80082-1 · Cited by 399 · see citing works

Neuronal adaptation to amphetamine and dopamine: Molecular mechanisms of prodynorphin gene regulation in rat striatum

Cole, R. L., Konradi, C. L., DOUGLASS, J. O., & Hyman, S. E. (1995) · Neuron · doi:10.1016/0896-6273(95)90225-2 · Cited by 365 · see citing works

Synaptic plasticity and mood disorders

Duman, R. S. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001016 · Cited by 363 · see citing works

Involvement of cAMP-dependent protein kinase in the nucleus accumbens in cocaine self-administration and relapse of cocaine-seeking behavior

Self, D. W., Genova, L. M., Hope, B. T., Barnhart, W. J., Spencer, J. J., & Nestler, E. J. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-05-01848.1998 · Cited by 325 · see citing works

Inhibition of cAMP response element-binding protein or dynorphin in the nucleus accumbens produces an antidepressant-like effect

Newton, S. S., Thome, J., Wallace, T. L., Shirayama, Y., Schlesinger, L., Sakai, N., Chen, J., Neve, R., Nestler, E. J., & Duman, R. S. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-24-10883.2002 · Cited by 313 · see citing works

Chronic Fos-Related Antigens: Stable Variants of ΔFosB Induced in Brain by Chronic Treatments

Chen, J., Kelz, M. B., Hope, B. T., Nakabeppu, Y., & Nestler, E. J. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-13-04933.1997 · Cited by 286 · see citing works

Network-Level Changes in Expression of Inducible Fos–Jun Proteins in the Striatum during Chronic Cocaine Treatment and Withdrawal

Moratalla, R., Elibol, B., Vallejo, M., & Graybiel, A. M. (1996) · Neuron · doi:10.1016/s0896-6273(00)80288-3 · Cited by 276 · see citing works

Genetic approaches to memory storage.

Mayford, M., & Kandel, E. (1999) · Trends in Genetics · doi:10.1016/s0168-9525(99)01846-6 · Cited by 260 · see citing works

Striatal Cell Type-Specific Overexpression of ΔFosB Enhances Incentive for Cocaine

Colby, C. R., Whisler, K., Steffen, C., Nestler, E. J., & Self, D. W. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-06-02488.2003 · Cited by 217 · see citing works

Transgenic animals with inducible, targeted gene expression in brain.

Chen, J.-S., Kelz, M., Zeng, G., Sakai, N., Steffen, C., Shockett, P. E., Picciotto, M., Duman, R., & Nestler, E. J. (1998) · Molecular Pharmacology · doi:10.1124/mol.54.3.495 · Cited by 194 · see citing works

Transformation suppressor activity of a Jun transcription factor lacking its activation domain

Lloyd, A. C., Yancheva, N., & Wasylyk, B. (1991) · Nature · doi:10.1038/352635a0 · Cited by 189 · see citing works

Different Requirements for cAMP Response Element Binding Protein in Positive and Negative Reinforcing Properties of Drugs of Abuse

Walters, C. L., & Blendy, J. A. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-23-09438.2001 · Cited by 175 · see citing works

Induction of nuclear factor‐κB in nucleus accumbens by chronic cocaine administration

Ang, E. S. B. C., Chen, J., Zagouras, P., Magna, H. A., Holland, J., Schaeffer, E., & Nestler, E. J. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00563.x · Cited by 146 · see citing works

cAMP Response Element-Binding Protein Is Required for Dopamine-Dependent Gene Expression in the Intact But Not the Dopamine-Denervated Striatum

Andersson, M., Konradi, C. L., & Cenci, M. A. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-24-09930.2001 · Cited by 146 · see citing works

An alternative spliced form of FosB is a negative regulator of transcriptional activation and transformation by Fos proteins.

Yen, J., Wisdom, R., Tratner, I., & Verma, I. M. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.12.5077 · Cited by 143 · see citing works

Differential gene expression in the rat caudate putamen after “binge” cocaine administration: advantage of triplicate microarray analysis

Yuferov, V., Kroslak, T., Laforge, K. S., Zhou, Y., Ho, A., & Kreek, M. J. (2003) · Synapse · doi:10.1002/syn.10198 · Cited by 143 · see citing works

Enhanced CREB phosphorylation and changes in c-Fos and FRA expression in striatum accompany amphetamine sensitization

Turgeon, S. M., Pollack, A. E., & Fink, J. S. (1997) · Brain Research · doi:10.1016/s0006-8993(96)01316-9 · Cited by 129 · see citing works

Chronic cocaine‐mediated changes in non‐human primate nucleus accumbens gene expression

Freeman, W. M., Nader, M. A., Nader, S. H., Robertson, D. J., Gioia, L., Mitchell, S. M., Daunais, J. B., Porrino, L. J., Friedman, D. P., & Vrana, K. E. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00252.x · Cited by 122 · see citing works

Decreased expression of the transcription factor NURR1 in dopamine neurons of cocaine abusers

Bannon, M. J., Pruetz, B., Manning-Bog, A., Whitty, C. J., Michelhaugh, S. K., Sacchetti, P., Granneman, J. G., Mash, D. C., & Schmidt, C. J. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.092654299 · Cited by 109 · see citing works

Inducible, brain region-specific expression of a dominant negative mutant of c-Jun in transgenic mice decreases sensitivity to cocaine

Peakman, M., Colby, C. R., Perrotti, L. I., Tekumalla, P. K., Carle, T. L., Ulery, P. G., Chao, J. R., Duman, C. H., Steffen, C., Monteggia, L. M., et al. (2003) · Brain Research · doi:10.1016/s0006-8993(03)02230-3 · Cited by 103 · see citing works

Enhanced Inhibition of Synaptic Transmission by Dopamine in the Nucleus Accumbens during Behavioral Sensitization to Cocaine

Beurrier, C., & Malenka, R. C. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-14-05817.2002 · Cited by 102 · see citing works

Calmodulin Kinase II Attenuation of Gene Transcription by Preventing cAMP Response Element-binding Protein (CREB) Dimerization and Binding of the CREB-binding Protein

Wu, X., & McMurray, C. T. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m006727200 · Cited by 102 · see citing works

Induction of Cyclin-Dependent Kinase 5 in the Hippocampus by Chronic Electroconvulsive Seizures: Role of ΔFosB

Chen, J., Zhang, Y., Kelz, M. B., Steffen, C., Ang, E. S., Zeng, L., & Nestler, E. J. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-24-08965.2000 · Cited by 101 · see citing works

Periadolescent Mice Show Enhanced ΔFosB Upregulation in Response to Cocaine and Amphetamine

Ehrlich, M. E., Sommer, J., Canas, E., & Unterwald, E. M. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-21-09155.2002 · Cited by 98 · see citing works

Both products of the fosB gene, FosB and its short form, FosB/SF, are transcriptional activators in fibroblasts.

Dobrazanski, P., Noguchi, T., Kovary, K., Rizzo, C. A., Lazo, P. S., & Bravo, R. (1991) · Molecular and Cellular Biology · doi:10.1128/mcb.11.11.5470 · Cited by 97 · see citing works

Regulation of CRE‐mediated transcription in mouse brain by amphetamine

Shaw‐Lutchman, T. Z., Impey, S., Storm, D. R., & Nestler, E. J. (2003) · Synapse · doi:10.1002/syn.10172 · Cited by 92 · see citing works

Chronic repeated cocaine administration alters basal and opioid‐regulated adenylyl cyclase activity

Unterwald, E. M., Cox, B. M., Kreek, M. J., Cote, T. E., & Izenwasser, S. (1993) · Synapse · doi:10.1002/syn.890150104 · Cited by 73 · see citing works

Inducible and Brain Region-Specific CREB Transgenic Mice

Sakai, N., Thome, J., Newton, S. S., Chen, J., Kelz, M. B., Steffen, C., Nestler, E. J., & Duman, R. S. (2002) · Molecular Pharmacology · doi:10.1124/mol.61.6.1453 · Cited by 69 · see citing works

Dominant-negative mutants of cJun inhibit AP-1 activity through multiple mechanisms and with different potencies.

Brown, P. H., Kim, S. H., Wise, S., Sabichi, A. L., & Birrer, M. J. (1996) · PubMed · Cited by 62 · see citing works

Cholecystokinin/dopamine/GABA interactions in the nucleus accumbens: biochemical and functional correlates

Tanganelli, S., Fuxé, K., Antonelli, T., O'Connor, W. T., & Ferraro, L. (2001) · Peptides · doi:10.1016/s0196-9781(01)00446-6 · Cited by 36 · see citing works

Forskolin induces preproenkephalin and preprodynorphin mRNA in rat striatum as demonstrated by in situ hybridization histochemistry

Simpson, J. N., & McGinty, J. F. (1995) · Synapse · doi:10.1002/syn.890190302 · Cited by 35 · see citing works

Cocaine treatment increases extracellular cholecystokinin (CCK) in the nucleus accumbens shell of awake, freely moving rats, an effect that is enhanced in rats that are behaviorally sensitized to cocaine

Beinfeld, M. C., Connolly, K., & Pierce, R. C. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.00894.x · Cited by 30 · see citing works

Differences in expression, actions and cocaine regulation of two isoforms for the brain transcriptional regulator NAC1

Korutla, L., Wang, P. J., Lewis, D., et al. (2002) · Neuroscience · doi:10.1016/s0306-4522(01)00518-8 · Cited by 21 · see citing works

PD-135158, a CCKB receptor antagonist, microinjected into the nucleus accumbens and the expression of conditioned rewarded behavior

Josselyn, S. A., Franco, V. P., & Vaccarino, F. J. (1996) · Neuroscience Letters · doi:10.1016/0304-3940(96)12610-0 · Cited by 10 · see citing works

The Neural Basis of Addiction: A Pathology of Motivation and Choice

Kalivas, P. W., & Volkow, N. D. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.8.1403 · Cited by 2,757 · see citing works

The mesolimbic dopamine reward circuit in depression

Nestler, E. J., & Carlezon, W. A. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.09.018 · Cited by 2,059 · see citing works

The brain reward circuitry in mood disorders

Russo, S. J., & Nestler, E. J. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3381 · Cited by 1,870 · see citing works

Is there a common molecular pathway for addiction?

Nestler, E. J. (2005) · Nature Neuroscience · doi:10.1038/nn1578 · Cited by 1,388 · see citing works

Epigenetic regulation in psychiatric disorders

Tsankova, N., Renthal, W., Kumar, A., & Nestler, E. J. (2007) · Nature reviews. Neuroscience · doi:10.1038/nrn2132 · Cited by 1,400 · see citing works

REVIEW ON CPP: Measuring reward with the conditioned place preference (CPP) paradigm: update of the last decade

Tzschentke, T. M. (2007) · Addiction Biology · doi:10.1111/j.1369-1600.2007.00070.x · Cited by 1,336 · see citing works

A translational profiling approach for the molecular characterization of CNS cell types

Heiman, M., Schaefer, A., Gong, S., Peterson, J. D., Day, M., Ramsey, K. E., Suárez-Fariñas, M., Schwarz, C., Stephan, D. A., Surmeier, D. J., et al. (2008) · Cell · doi:10.1016/j.cell.2008.10.028 · Cited by 1,134 · see citing works

Molecular mechanisms of drug addiction

Nestler, E. J. (2004) · Neuropharmacology · doi:10.1016/j.neuropharm.2004.06.031 · Cited by 1,108 · see citing works

Addiction: A Disease of Learning and Memory

Hyman, S. E. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.8.1414 · Cited by 980 · see citing works

Chromatin Remodeling Is a Key Mechanism Underlying Cocaine-Induced Plasticity in Striatum

Kumar, A., Choi, K.-H., Renthal, W., Tsankova, N. M., Theobald, D. E. H., Truong, H.-T., Russo, S. J., LaPlant, Q., Sasaki, T. S., Whistler, K. N., et al. (2005) · Neuron · doi:10.1016/j.neuron.2005.09.023 · Cited by 764 · see citing works

Essential Role of the Histone Methyltransferase G9a in Cocaine-Induced Plasticity

Maze, I., Covington, H. E., Dietz, D. M., LaPlant, Q., Renthal, W., Russo, S. J., Mechanic, M., Mouzon, E., Neve, R. L., Haggarty, S. J., et al. (2010) · Science · doi:10.1126/science.1179438 · Cited by 665 · see citing works

The addicted synapse: mechanisms of synaptic and structural plasticity in nucleus accumbens

Russo, S. J., Dietz, D. M., Dumitriu, D., Morrison, J. H., Malenka, R. C., & Nestler, E. J. (2010) · Trends in Neurosciences · doi:10.1016/j.tins.2010.02.002 · Cited by 654 · see citing works

Nova regulates brain-specific splicing to shape the synapse

Ule, J., Ule, A., Spencer, J., Williams, A., Hu, J.-S., Cline, M., Wang, H., Clark, T., Fraser, C., Ruggiu, M., et al. (2005) · Nature Genetics · doi:10.1038/ng1610 · Cited by 509 · see citing works

Epigenetic mechanisms in cognition

Day, J. J., & Sweatt, J. D. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.019 · Cited by 510 · see citing works

ΔFosB in brain reward circuits mediates resilience to stress and antidepressant responses

Vialou, V., Robison, A. J., LaPlant, Q. C., Covington, H. E., Dietz, D. M., Ohnishi, Y. N., Mouzon, E., Rush, A. J., Watts, E. L., Wallace, D. L., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2551 · Cited by 479 · see citing works

Regulation of dopaminergic transmission and cocaine reward by the <i>Clock</i> gene

McClung, C. A., Sidiropoulou, K., Vitaterna, M., Takahashi, J. S., White, F. J., Cooper, D. C., & Nestler, E. J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503584102 · Cited by 493 · see citing works

Historical review: molecular and cellular mechanisms of opiate and cocaine addiction

Nestler, E. J. (2004) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2004.02.005 · Cited by 425 · see citing works

Genome-wide Analysis of Chromatin Regulation by Cocaine Reveals a Role for Sirtuins

Renthal, W., Kumar, A., Xiao, G., Wilkinson, M., Covington, H. E., Maze, I., Sikder, D., Robison, A. J., LaPlant, Q., Dietz, D. M., et al. (2009) · Neuron · doi:10.1016/j.neuron.2009.03.026 · Cited by 409 · see citing works

Pharmacogenetics and Human Molecular Genetics of Opiate and Cocaine Addictions and Their Treatments

Kreek, M. J., Bart, G., Lilly, C., Laforge, K. S., & Nielsen, D. A. (2005) · Pharmacological Reviews · doi:10.1124/pr.57.1.1 · Cited by 391 · see citing works

Common cellular and molecular mechanisms in obesity and drug addiction

Kenny, P. J. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3105 · Cited by 382 · see citing works

Epigenetic regulation of gene expression in physiological and pathological brain processes

Gräff, J., Kim, D., Dobbin, M. M., & Tsai, L.-H. (2011) · Physiological Reviews · doi:10.1152/physrev.00012.2010 · Cited by 373 · see citing works

CREB regulation of nucleus accumbens excitability mediates social isolation–induced behavioral deficits

Wallace, D. L., Han, M.-H., Graham, D. L., Green, T. A., Vialou, V., Iñiguez, S. D., Cao, J.-L., Kirk, A., Chakravarty, S., Kumar, A., et al. (2009) · Nature Neuroscience · doi:10.1038/nn.2257 · Cited by 342 · see citing works

Afferents to the GABAergic tail of the ventral tegmental area in the rat

Kaufling, J., Veinante, P., Pawlowski, S. A., Freund‐Mercier, M., & Barrot, M. (2009) · Journal of Comparative Neurology · doi:10.1002/cne.21983 · Cited by 347 · see citing works

Neuroplasticity Mediated by Altered Gene Expression

McClung, C. A., & Nestler, E. J. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301544 · Cited by 347 · see citing works

The Neurobiology of Cocaine Addiction

Nestler, E. (2005) · Science &amp; Practice Perspectives · doi:10.1151/spp05314 · Cited by 367 · see citing works

Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings

Dichter, G. S., Damiano, C. A., & Allen, J. A. (2012) · Journal of Neurodevelopmental Disorders · doi:10.1186/1866-1955-4-19 · Cited by 299 · see citing works

Does the Concept of "Sensitization" Provide a Plausible Mechanism for the Putative Link Between the Environment and Schizophrenia?

Collip, D., Myin-Germeys, I., & Van Os, J. (2007) · Schizophrenia Bulletin · doi:10.1093/schbul/sbm163 · Cited by 305 · see citing works

Prefrontal Cortical Circuit for Depression- and Anxiety-Related Behaviors Mediated by Cholecystokinin: Role of ΔFosB

Vialou, V., Bagot, R. C., Cahill, M. E., Ferguson, D., Robison, A. J., Dietz, D. M., Fallon, B., Mazei-Robison, M., Ku, S. M., Harrigan, E., et al. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.1787-13.2014 · Cited by 283 · see citing works

A Role for Repressive Histone Methylation in Cocaine-Induced Vulnerability to Stress

Covington, H. E., Maze, I., Sun, H., Bomze, H. M., DeMaio, K. D., Wu, E. Y., Dietz, D. M., Lobo, M. K., Ghose, S., Mouzon, E., et al. (2011) · Neuron · doi:10.1016/j.neuron.2011.06.007 · Cited by 289 · see citing works

HDAC4 Governs a Transcriptional Program Essential for Synaptic Plasticity and Memory

Sando, R., Gounko, N., Pieraut, S., Liao, L., Yates, J., & Maximov, A. (2012) · Cell · doi:10.1016/j.cell.2012.09.037 · Cited by 274 · see citing works

ΔFosB Induction in Striatal Medium Spiny Neuron Subtypes in Response to Chronic Pharmacological, Emotional, and Optogenetic Stimuli

Lobo, M. K., Zaman, S., Damez-Werno, D. M., Koo, J. W., Bagot, R. C., DiNieri, J. A., Nugent, A., Finkel, E., Chaudhury, D., Chandra, R., et al. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.1875-13.2013 · Cited by 245 · see citing works

Aberrant learning and memory in addiction

Torregrossa, M. M., Corlett, P. R., & Taylor, J. R. (2011) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2011.02.014 · Cited by 223 · see citing works

Candidate genes, pathways and mechanisms for bipolar (manic-depressive) and related disorders: an expanded convergent functional genomics approach

Ogden, C. A., Rich, M. E., Schork, N. J., Paulus, M. P., Geyer, M. A., Lohr, J. B., Kuczenski, R., & Niculescu, A. B. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001547 · Cited by 221 · see citing works

∆FosB: A transcriptional regulator of stress and antidepressant responses

Nestler, E. J. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2014.10.034 · Cited by 220 · see citing works

FosB differentially modulates nucleus accumbens direct and indirect pathway function

Grueter, B. A., Robison, A. J., Neve, R. L., Nestler, E. J., & Malenka, R. C. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1221742110 · Cited by 191 · see citing works

Behavioral and Structural Responses to Chronic Cocaine Require a Feedforward Loop Involving ΔFosB and Calcium/Calmodulin-Dependent Protein Kinase II in the Nucleus Accumbens Shell

Robison, A. J., Vialou, V., Mazei-Robison, M., Feng, J., Kourrich, S., Collins, M., Wee, S., Koob, G., Turecki, G., Neve, R., et al. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.5192-12.2013 · Cited by 190 · see citing works

BDNF is a negative modulator of morphine action

Koo, J. W., Mazei-Robison, M. S., Chaudhury, D., Juarez, B., LaPlant, Q., Ferguson, D., Feng, J., Sun, H., Scobie, K. N., Damez-Werno, D., et al. (2012) · Science · doi:10.1126/science.1222265 · Cited by 189 · see citing works

Reciprocal effects on neurocognitive and metabolic phenotypes in mouse models of 16p11.2 deletion and duplication syndromes

Arbogast, T., Ouagazzal, A.-M., Chevalier, C., Kopanitsa, M., Afinowi, N., Migliavacca, E., Cowling, B. S., Birling, M.-C., Champy, M.-F., Reymond, A., et al. (2016) · PLOS Genetics · doi:10.1371/journal.pgen.1005709 · Cited by 151 · see citing works

ΔFosB accumulates in a GABAergic cell population in the posterior tail of the ventral tegmental area after psychostimulant treatment

Perrotti, L. I., Bolaños, C. A., Choi, K., Russo, S. J., Edwards, S., Ulery, P. G., Wallace, D. L., Self, D. W., Nestler, E. J., & Barrot, M. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04110.x · Cited by 178 · see citing works

A dopamine-induced gene expression signature regulates neuronal function and cocaine response

Savell, K. E., Tuscher, J. J., Zipperly, M. E., Duke, C. G., Phillips, R. A., Bauman, A. J., Thukral, S., Sultan, F. A., Goska, N. A., Ianov, L., et al. (2020) · Science Advances · doi:10.1126/sciadv.aba4221 · Cited by 180 · see citing works

Environmental enrichment during early stages of life reduces the behavioral, neurochemical, and molecular effects of cocaine

Solinas, M., Thiriet, N., Rawas, R. E., Lardeux, V., & Jaber, M. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2008.51 · Cited by 175 · see citing works

Role of Tumor Necrosis Factor-α in Methamphetamine-Induced Drug Dependence and Neurotoxicity

Nakajima, A., Yamada, K., Nagai, T., Uchiyama, T., Miyamoto, Y., Mamiya, T., He, J., Nitta, A., Mizuno, M., Tran, M. H., et al. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.4847-03.2004 · Cited by 176 · see citing works

The neural rejuvenation hypothesis of cocaine addiction

Dong, Y., & Nestler, E. J. (2014) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2014.05.005 · Cited by 163 · see citing works

Mechanisms of Action and Persistent Neuroplasticity by Drugs of Abuse

Korpi, E. R., den Hollander, B., Farooq, U., Vashchinkina, E., Rajkumar, R., Nutt, D. J., Hyytiä, P., & Dawe, G. S. (2015) · Pharmacological Reviews · doi:10.1124/pr.115.010967 · Cited by 148 · see citing works

A role for the circadian genes in drug addiction

Falcón, E., & McClung, C. A. (2009) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.06.054 · Cited by 135 · see citing works

Induction of ΔFosB in the Periaqueductal Gray by Stress Promotes Active Coping Responses

Berton, O., Covington, H. E., Ebner, K., Tsankova, N. M., Carle, T. L., Ulery, P., Bhonsle, A., Barrot, M., Krishnan, V., Singewald, G. M., et al. (2007) · Neuron · doi:10.1016/j.neuron.2007.06.033 · Cited by 129 · see citing works

Manipulating a “Cocaine Engram” in Mice

Hsiang, H.-L. (., Epp, J. R., van den Oever, M. C., Yan, C., Rashid, A. J., Insel, N., Ye, L., Niibori, Y., Deisseroth, K., Frankland, P. W., et al. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.3327-14.2014 · Cited by 131 · see citing works

Epigenetics of drug abuse: predisposition or response

Nielsen, D. A., Utrankar, A., Reyes, J. A., Simons, D. D., & Kosten, T. R. (2012) · Pharmacogenomics · doi:10.2217/pgs.12.94 · Cited by 125 · see citing works

Cell-Type-Specific Epigenetic Editing at the Fosb Gene Controls Susceptibility to Social Defeat Stress

Hamilton, P. J., Burek, D. J., Lombroso, S. I., Neve, R. L., Robison, A. J., Nestler, E. J., & Heller, E. A. (2018) · Neuropsychopharmacology · doi:10.1038/npp.2017.88 · Cited by 113 · see citing works

Circadian genes <i><scp>P</scp>eriod 1</i> and <i><scp>P</scp>eriod 2</i> in the nucleus accumbens regulate anxiety‐related behavior

Spencer, S., Falcon, E., Kumar, J., Krishnan, V., Mukherjee, S., Birnbaum, S. G., & McClung, C. A. (2013) · European Journal of Neuroscience · doi:10.1111/ejn.12010 · Cited by 113 · see citing works

Histone acetylation in drug addiction

Renthal, W., & Nestler, E. J. (2009) · Seminars in Cell &amp; Developmental Biology · doi:10.1016/j.semcdb.2009.01.005 · Cited by 109 · see citing works

Direct Regulation of Diurnal Drd3 Expression and Cocaine Reward by NPAS2

Ozburn, A. R., Falcon, E., Twaddle, A., Nugent, A. L., Gillman, A. G., Spencer, S. M., Arey, R. N., Mukherjee, S., Lyons-Weiler, J., Self, D. W., et al. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.07.030 · Cited by 110 · see citing works

Role of the Brain's Reward Circuitry in Depression

Nestler, E. J. (2015) · International review of neurobiology · doi:10.1016/bs.irn.2015.07.003 · Cited by 108 · see citing works

Fluoxetine Epigenetically Alters the CaMKIIα Promoter in Nucleus Accumbens to Regulate ΔFosB Binding and Antidepressant Effects

Robison, A. J., Vialou, V., Sun, H.-S., Labonte, B., A Golden, S., Dias, C., Turecki, G., Tamminga, C., Russo, S., Mazei-Robison, M., et al. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2013.319 · Cited by 105 · see citing works

CREB-Dependent Regulation of GAD65 Transcription by BDNF/TrkB in Cortical Interneurons

Sánchez-Huertas, C., & Rico, B. (2011) · Cerebral Cortex · doi:10.1093/cercor/bhq150 · Cited by 96 · see citing works

Stimulant-induced adaptations in neostriatal matrix and striosome systems: Transiting from instrumental responding to habitual behavior in drug addiction

CANALES, J. (2005) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2004.10.006 · Cited by 95 · see citing works

Additive effects of histone deacetylase inhibitors and amphetamine on histone H4 acetylation, cAMP responsive element binding protein phosphorylation and ΔFosB expression in the striatum and locomotor sensitization in mice

Shen, H.-Y., Kalda, A., Yu, L., Ferrara, J., Zhu, J., & Chen, J.-F. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.09.019 · Cited by 91 · see citing works

Feed-forward mechanisms: Addiction-like behavioral and molecular adaptations in overeating

Alsiö, J., Olszewski, P. K., Levine, A. S., & Schiöth, H. B. (2012) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2012.01.002 · Cited by 81 · see citing works

In vivo locus-specific editing of the neuroepigenome

Yim, Y. Y., Teague, C. D., & Nestler, E. J. (2020) · Nature Reviews Neuroscience · doi:10.1038/s41583-020-0334-y · Cited by 76 · see citing works

The anxious amygdala: CREB signaling and predisposition to anxiety and alcoholism

Wand, G. (2005) · Journal of Clinical Investigation · doi:10.1172/jci26436 · Cited by 66 · see citing works

<i>Fosb</i>gene products contribute to excitotoxic microglial activation by regulating the expression of complement C5a receptors in microglia: <i>Fosb</i>Regulates Expression of C5a Receptors

Nomaru, H., Sakumi, K., Katogi, A., Ohnishi, Y. N., Kajitani, K., Tsuchimoto, D., Nestler, E. J., & Nakabeppu, Y. (2014) · Glia · doi:10.1002/glia.22680 · Cited by 68 · see citing works

CRACKing the histone code: Cocaine's effects on chromatin structure and function

LaPlant, Q., & Nestler, E. J. (2011) · Hormones and Behavior · doi:10.1016/j.yhbeh.2010.05.015 · Cited by 52 · see citing works

Chronic exposure to Δ9-tetrahydrocannabinol downregulates oxytocin and oxytocin-associated neurophysin in specific brain areas

Butovsky, E., Juknat, A., Elbaz, J., Shabat-Simon, M., Eilam, R., Zangen, A., Altstein, M., & Vogel, Z. (2006) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2006.01.008 · Cited by 52 · see citing works

Mechanisms of HIV transcriptional regulation by drugs of abuse

Tyagi, M., Bukrinsky, M., & L. Simon, G. (2016) · Current HIV Research · doi:10.2174/1570162x14666160324124736 · Cited by 42 · see citing works

Attention deficits and hyperactivity following inhibition of cAMP-dependent protein kinase within the medial prefrontal cortex of rats

Paine, T. A., Neve, R. L., & Carlezon, W. A. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.40 · Cited by 40 · see citing works

Glucocorticoid receptor-regulated enhancers play a central role in the gene regulatory networks underlying drug addiction

Duttke, S. H., Montilla-Perez, P., Chang, M. W., Li, H., Chen, H., Carrette, L. L. G., Guglielmo, G. D., George, O., Palmer, A. A., Benner, C., et al. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.858427 · Cited by 26 · see citing works

Stress as a Risk Factor for Substance Use Disorders: A Mini-Review of Molecular Mediators

Mukhara, D., Banks, M. L., & Neigh, G. N. (2018) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2018.00309 · Cited by 26 · see citing works

Persistent gene expression changes in ventral tegmental area of adolescent but not adult rats in response to chronic nicotine

Doura, M. B., Luu, T. V., Lee, N. H., & Perry, D. C. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.06.071 · Cited by 24 · see citing works

Modulation of CREB expression and phosphorylation in the rat nucleus accumbens during nicotine exposure and withdrawal

Pluzarev, O., & Pandey, S. C. (2004) · Journal of Neuroscience Research · doi:10.1002/jnr.20216 · Cited by 39 · see citing works

Changes of phosphorylation of cAMP response element binding protein in rat nucleus accumbens after chronic ethanol intake: naloxone reversal.

Li, J., Li, Y., & Xiao-ru, Y. (2003) · PubMed · Cited by 34 · see citing works

Differential distribution of CREB in the mesolimbic dopamine reward pathway

Walters, C. L., Kuo, Y., & Blendy, J. A. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.02090.x · Cited by 97 · see citing works

Faculty Opinions recommendation of Overexpression of CREB in the nucleus accumbens shell increases cocaine reinforcement in self-administering rats.

Shaham, Y., & Calu, D. J. (2011) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.13370984.14741090

Antisense-induced reduction in nucleus accumbens cyclic AMP response element binding protein attenuates cocaine reinforcement

Choi, K. H., Whisler, K. N., Graham, D. L., & Self, D. W. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.10.049 · Cited by 53 · see citing works