The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
KCNJ10 (Kir4.1) potassium channel knockout abolishes endocochlear potential
Abstract
Stria vascularis of the cochlea generates the endocochlear potential and secretes K+. K+ is the main charge carrier and the endocochlear potential the main driving force for the sensory transduction that leads to hearing. Stria vascularis consists of two barriers, marginal cells that secrete potassium and basal cells that are coupled via gap junctions to intermediate cells. Mice lacking the KCNJ10 (Kir4.1) K+ channel in strial intermediate cells did not generate an endocochlear potential. Endolymph volume and K+ concentration ([K+]) were reduced. These studies establish that the KCNJ10 K+ channel provides the molecular mechanism for generation of the endocochlear potential in concert with other transport pathways that establish the [K+] difference across the channel. KCNJ10 is also a limiting pathway for K+ secretion.
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Cites
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Inner Ear Defects Induced by Null Mutationof the isk Gene
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Self-citationTargeted disruption of the Kvlqt1 gene causes deafness and gastric hyperplasia in mice
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Self-citation
Cited by
Inwardly Rectifying Potassium Channels: Their Structure, Function, and Physiological Roles
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Connexin30 (Gjb6)-deficiency causes severe hearing impairment and lack of endocochlear potential
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Ben-Yosef, T. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddg210 · Cited by 339
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Binder, D. K., & Steinhäuser, C. (2006) · Glia · doi:10.1002/glia.20394 · Cited by 300
Metadata
- Authors
- Marcus, D. C., Wu, T., Wangemann, P., & Kofuji, P.
- Venue
- American Journal of Physiology-Cell Physiology
- Publisher
- American Physiological Society
- Published
- 2002-02-01
- Volume
- 282
- Issue
- 2
- Pages
- C403-C407
- ISSN
- 0363-6143 (ISSN-L)
- 1522-1563
- OpenAlex
- W2146961403
- Cited by
- 332
- References
- 19
- FWCI
- 7.49
- Type
- journal article
- Language
- en
- Open access
- closed
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- Marcus, D. C., Wu, T., Wangemann, P., & Kofuji, P. (2002). KCNJ10 (Kir4.1) potassium channel knockout abolishes endocochlear potential. American Journal of Physiology-Cell Physiology. https://doi.org/10.1152/ajpcell.00312.2001
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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