The DOI matches its Crossref record; 153 of the 153 references it cites were found in a registry or an index.
Functional changes in astroglial cells in epilepsy
Abstract
Epilepsy comprises a group of disorders characterized by the periodic occurrence of seizures, and pathologic specimens from patients with temporal lobe epilepsy demonstrate marked reactive gliosis. Since recent studies have implicated glial cells in novel physiological roles in the CNS, such as modulation of synaptic transmission, it is plausible that glial cells may have a functional role in the hyperexcitability characteristic of epilepsy. Indeed, alterations in distinct astrocyte membrane channels, receptors and transporters have all been associated with the epileptic state. This review integrates the current evidence regarding astroglial dysfunction in epilepsy and the potential underlying mechanisms of hyperexcitability. Functional understanding of the cellular and molecular alterations of astroglia‐dependent hyperexcitability will help to clarify the physiological role of astrocytes in neural function as well as lead to the identification of novel therapeutic targets. © 2006 Wiley‐Liss, Inc.
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Glia and epilepsy: excitability and inflammation
Devinsky, O., Vezzani, A., Najjar, S., De Lanerolle, N. C., & Rogawski, M. A. (2013) · Trends in Neurosciences · doi:10.1016/j.tins.2012.11.008 · Cited by 867
Selective induction of astrocytic gliosis generates deficits in neuronal inhibition
Ortinski, P. I., Dong, J., Mungenast, A., Yue, C., Takano, H., Watson, D. J., Haydon, P. G., & Coulter, D. A. (2010) · Nature Neuroscience · doi:10.1038/nn.2535 · Cited by 495
Adenosine signaling and function in glial cells
Boison, D., Chen, J.-F., & Fredholm, B. B. (2010) · Cell Death & Differentiation · doi:10.1038/cdd.2009.131 · Cited by 306
Astrocytes in the initiation and progression of epilepsy
Vezzani, A., Ravizza, T., Bedner, P., Aronica, E., Steinhäuser, C., & Boison, D. (2022) · Nature Reviews Neurology · doi:10.1038/s41582-022-00727-5 · Cited by 272
Self-citationMultifunctional role of astrocytes as gatekeepers of neuronal energy supply
Stobart, J. L., & Anderson, C. M. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00038 · Cited by 264
Metadata
- Authors
- Binder, D. K., & Steinhäuser, C.
- Venue
- Glia
- Publisher
- Wiley
- Published
- 2006-08-02
- Volume
- 54
- Issue
- 5
- Pages
- 358-368
- ISSN
- 0894-1491 (ISSN-L)
- 1098-1136
- OpenAlex
- W2102561151
- Cited by
- 300
- References
- 153
- FWCI
- 11.31
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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