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Toll-Like Receptor 4 Mutation Protects Obese Mice Against Endothelial Dysfunction by Decreasing NADPH Oxidase Isoforms 1 and 4

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TXNIP potentiates Redd1-induced mTOR suppression through stabilization of Redd1

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Endothelial dysfunction and cardiometabolic diseases: Role of long non-coding RNAs

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Txnip ablation reduces vascular smooth muscle cell inflammation and ameliorates atherosclerosis in apolipoprotein E knockout mice

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Suppression of REDD1 in osteoarthritis cartilage, a novel mechanism for dysregulated mTOR signaling and defective autophagy

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Anti-inflammatory evaluation of the methanolic extract of Taraxacum officinale in LPS-stimulated human umbilical vein endothelial cells

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Endothelial Cells Overexpressing Interleukin-8 Receptors Reduce Inflammatory and Neointimal Responses to Arterial Injury

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Estradiol Regulates Txnip and Prevents Intermittent Hypoxia-Induced Vascular Injury

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Dual specificity phosphatase DUSP 6 promotes endothelial inflammation through inducible expression of ICAM ‐1

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Rtp801 Suppression of Epithelial mTORC1 Augments Endotoxin-Induced Lung Inflammation

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Digitoflavone (DG) attenuates LPS-induced acute lung injury through reducing oxidative stress and inflammatory response dependent on the suppression of TXNIP/NLRP3 and NF-κB

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Septin4 as a novel binding partner of PARP1 contributes to oxidative stress induced human umbilical vein endothelial cells injure

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Lipopolysaccharide induction of REDD1 is mediated by two distinct CREB‐dependent mechanisms in macrophages

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Cynandione�A inhibits lipopolysaccharide-induced cell adhesion via suppression of the protein expression of VCAM‑1 in human endothelial cells

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Senolytic Combination of Dasatinib and Quercetin Alleviates Intestinal Senescence and Inflammation and Modulates the Gut Microbiome in Aged Mice

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Is REDD1 a metabolic double agent? Lessons from physiology and pathology

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The Emerging Role of TXNIP in Ischemic and Cardiovascular Diseases; A Novel Marker and Therapeutic Target

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Geniposide Combined With Notoginsenoside R1 Attenuates Inflammation and Apoptosis in Atherosclerosis via the AMPK/mTOR/Nrf2 Signaling Pathway

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Gegen Qinlian pills alleviate carrageenan-induced thrombosis in mice model by regulating the HMGB1/NF-κB/NLRP3 signaling

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The stress-responsive protein REDD1 and its pathophysiological functions

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The Post-amyloid Era in Alzheimer's Disease: Trust Your Gut Feeling

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EPSTI1 promotes monocyte adhesion to endothelial cells in vitro via upregulating VCAM-1 and ICAM-1 expression

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Lycopene alleviates oxidative stress-induced cell injury in human vascular endothelial cells by encouraging the SIRT1/Nrf2/HO-1 pathway

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P53 in the impaired lungs

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Nutritional Sensor REDD1 in Cancer and Inflammation: Friend or Foe?

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The stress response protein REDD1 as a causal factor for oxidative stress in diabetic retinopathy

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Synergistic dual cell therapy for atherosclerosis regression: ROS-responsive Bio-liposomes co-loaded with Geniposide and Emodin

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Tetrahedral Framework Nucleic Acids Connected with MicroRNA-126 Mimics for Applications in Vascular Inflammation, Remodeling, and Homeostasis

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Sirtuin1 Mediates the Protective Effects of Echinacoside against Sepsis-Induced Acute Lung Injury via Regulating the NOX4-Nrf2 Axis

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Geniposide for treating atherosclerotic cardiovascular disease: a systematic review on its biological characteristics, pharmacology, pharmacokinetics, and toxicology

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Natural Biologics Accelerate Healing of Diabetic Foot Ulcers by Regulating Oxidative Stress

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Proanthocyanidins: A novel approach to Henoch‑Schonlein purpura through balancing immunity and arresting oxidative stress via TLR4/MyD88/NF‑κB signaling pathway (Review)

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REDD1 knockdown protects H9c2 cells against myocardial ischemia/reperfusion injury through Akt/mTORC1/Nrf2 pathway-ameliorated oxidative stress: An in vitro study

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CircRNA, lncRNA, and mRNA profiles of umbilical cord blood exosomes from preterm newborns showing bronchopulmonary dysplasia

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Down-Regulation of Essential Synaptic Components by GI-Tract Microbiome-Derived Lipopolysaccharide (LPS) in LPS-Treated Human Neuronal-Glial (HNG) Cells in Primary Culture: Relevance to Alzheimer’s Disease (AD)

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TXNIP in liver sinusoidal endothelial cells ameliorates alcohol-associated liver disease via nitric oxide production

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PERK/ATF4-dependent expression of the stress response protein REDD1 promotes proinflammatory cytokine expression in the heart of obese mice

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Paeoniflorin alleviates liver injury in hypercholesterolemic rats through the ROCK/AMPK pathway

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Comparative transcriptome analysis reveals immunoregulation mechanism of lncRNA-mRNA in gill and skin of large yellow croaker (Larimichthys crocea) in response to Cryptocaryon irritans infection

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Protective Effects of N-Acetylcysteine on Lipopolysaccharide-Induced Respiratory Inflammation and Oxidative Stress

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Small extracellular vesicles-transported lncRNA TDRKH-AS1 derived from AOPPs-treated trophoblasts initiates endothelial cells pyroptosis through PDIA4/DDIT4 axis in preeclampsia

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The Role of Endothelial Cell Mitophagy in Age-Related Cardiovascular Diseases

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Pyruvate dehydrogenase kinases: key regulators of cellular metabolism and therapeutic targets for metabolic diseases

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Evaluation of Endothelial Dysfunction and Autophagy in Fibromyalgia-Related Vascular and Cerebral Cortical Changes and the Ameliorative Effect of Fisetin

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Dapagliflozin attenuates cholesterol overloading-induced injury in mice hepatocytes with type 2 diabetes mellitus (T2DM) via eliminating oxidative damages

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Elephant seal muscle cells adapt to sustained glucocorticoid exposure by shifting their metabolic phenotype

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The BCL2/BAX/ROS pathway is involved in the inhibitory effect of astragaloside IV on pyroptosis in human umbilical vein endothelial cells

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Nitric oxide inhibits endothelial cell apoptosis by inhibiting cysteine‐dependent SOD1 monomerization

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Stress response protein REDD1 promotes diabetes-induced retinal inflammation by sustaining canonical NF-κB signaling

Sunilkumar, S., Toro, A. L., McCurry, C. M., VanCleave, A. M., Stevens, S. A., Miller, W. P., Kimball, S. R., & Dennis, M. D. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.102638 · Cited by 18 · see citing works

GATA2 promotes oxidative stress to aggravate renal ischemia-reperfusion injury by up-regulating Redd1

Huang, D. A., Chen, D., Hu, T., & Liang, H. (2022) · Molecular Immunology · doi:10.1016/j.molimm.2022.09.012 · Cited by 17 · see citing works

Inhibition of EZH2 attenuates coronary heart disease by interacting with microRNA‐22 to regulate the TXNIP/nuclear factor‐κB pathway

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New insights into the anti-apoptotic mechanism of natural polyphenols in complex with Bax protein

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Chimpanzee adenovirus-mediated multiple gene therapy for age-related macular degeneration

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Quercetin regulates vascular endothelium function in chronic renal failure via modulation of Eph/Cav‐1 signaling

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In silico high-throughput screening system for AKT1 activators with therapeutic applications in sepsis acute lung injury

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TXNIP knockdown protects rats against bupivacaine-induced spinal neurotoxicity via the inhibition of oxidative stress and apoptosis

Zhao, Y., Chen, Y., Liu, Z., Zhou, L., Huang, J., Luo, X., Luo, Y., Li, J., Lin, Y., Liu, J., et al. (2024) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2024.04.223 · Cited by 14 · see citing works

Omarigliptin/rosinidin combination ameliorates cyclophosphamide-induced lung toxicity in rats: The interaction between glucagon-like peptide-1, TXNIP/NLRP3 inflammasome signaling, and PI3K/Akt/FoxO1 axis

Elmaaboud, M. A. A., Kabel, A. M., Borg, H. M., Magdy, A. A., Kabel, S. M., Arafa, E. A., Alsufyani, S. E., & Arab, H. H. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117026 · Cited by 15 · see citing works

Poly(L-lactide-co-ɛ-caprolactone)/gelatin-based small-diameter vascular grafts: Salutatory effect of the BVLD and EGCG-Cu to promote hemocompatibility and nitric oxide production for in situ blood vessel regeneration

Cai, G., Yuan, Z., Wang, X., Wu, S., Zhou, S., Lei, Z., Li, P., EL-Newehy, M., Moydeen Abdulhameed, M., Shafiq, M., et al. (2024) · Chemical Engineering Journal · doi:10.1016/j.cej.2024.156555 · Cited by 13 · see citing works

TRIM59 attenuates ox-LDL-induced endothelial cell inflammation, apoptosis, and monocyte adhesion through AnxA2

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The investigation on sialic acid-modified pectin nanoparticles loaded with oxymatrine for orally targeting and inhibiting the of ulcerative colitis

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The involvement of Sting in exacerbating acute lung injury in sepsis via the PARP-1/NLRP3 signaling pathway

Ying, T., Yu, Y., Yu, Q., Zhou, G., Chen, L., Gu, Y., Zhu, L., Ying, H., & Chen, M. (2024) · Pulmonary Pharmacology & Therapeutics · doi:10.1016/j.pupt.2024.102303 · Cited by 12 · see citing works

Blocking REDD1/TXNIP Complex Ameliorates HG-Induced Renal Tubular Epithelial Cell Apoptosis and EMT through Repressing Oxidative Stress

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Decreased miR-17-92 cluster correlates with senescence features, disrupted oxidative homeostasis, and impaired therapeutic efficacy of mesenchymal stem cells

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A biomimetic tri-phasic scaffold with spatiotemporal patterns of gastrodin to regulate hierarchical tissue-based vascular regeneration

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REDD1 Is a Promising Therapeutic Target to Combat the Development of Diabetes Complications: A Report on Research Supported by Pathway to Stop Diabetes

Sunilkumar, S., & Dennis, M. D. (2024) · Diabetes · doi:10.2337/dbi24-0013 · Cited by 10 · see citing works

REDD1 knockdown ameliorates endothelial cell senescence through repressing TXNIP-mediated oxidative stress

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MicroRNA-136-5p from Endothelial Progenitor Cells-released Extracellular Vesicles Mediates TXNIP to Promote the Dissolution of Deep Venous Thrombosis

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Silencing p75NTR regulates osteogenic differentiation and angiogenesis of BMSCs to enhance bone healing in fractured rats

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TXNIP inhibits the progression of osteosarcoma through DDIT4-mediated mTORC1 suppression.

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Resveratrol inhibits LPS-induced apoptosis in bovine mammary epithelial cells: the role of PGC1α-SIRT3 axis

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ZPI prevents ox‐LDL‐mediated endothelial injury leading to inhibition of EndMT, inflammation, apoptosis, and oxidative stress through activating Pi3k/Akt signal pathway

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MiR-29b-3p Inhibits the Inflammation Injury in Human Umbilical Vein Endothelial Cells by Regulating SEC23A

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STAU1 exhibits a dual function by promoting amyloidogenesis and tau phosphorylation in cultured cells

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MicroRNA-383-5p Regulates Oxidative Stress in Mice with Acute Myocardial Infarction through the AMPK Signaling Pathway via PFKM

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B-Lymphoid Tyrosine Kinase Crosslinks Redox and Apoptosis Signaling Networks to Promote the Survival of Transplanted Bone Marrow Mesenchymal Stem Cells

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Alteration of Gene Expression After Entecavir and Pegylated Interferon Therapy in HBV-Infected Chimeric Mouse Liver

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Comparison of the efficacy of the mouse hepatic and renal antioxidant systems against inflammation-induced oxidative stress

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Sevoflurane preconditioning inhibits cardiomyocyte injury induced by oxygen‑glucose deprivation by modulating TXNIP

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Monotropein alleviates sepsis-associated encephalopathy by targeting matrix metalloproteinase-9

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Early Stress-Response Gene REDD1 Controls Oxazolone-Induced Allergic Contact Dermatitis

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Endothelial downregulation of nuclear m6A reader YTHDC1 promotes pulmonary vascular remodeling in sugen hypoxia model of pulmonary hypertension

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Differential Effect of 4H-Benzo[d] [1, 3]oxazines on the Proliferation of Breast Cancer Cell Lines

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1-nitropyrene triggers trophoblast dysfunction via EMPs-mediated ferroptosis through Glutathione peroxidase 4

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UBE2L3 Suppresses Oxidative Stress-regulated Necroptosis to Accelerate Osteosarcoma Progression

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Causal genes identification of giant cell arteritis in CD4+ Memory t cells: an integration of multi-omics and expression quantitative trait locus analysis

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Exosomes Derived from AT2R-Overexpressing BMSC Prevent Restenosis After Carotid Artery Injury by Attenuating the Injury-Induced Neointimal Hyperplasia

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Impacts of trelagliptin and remogliflozin alone and in combination with Alpha Lipoic Acid on cardiac function in streptozotocin-induced diabetes mellitus in rats

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REDD1 mediates HDM-induced nuclear-cytoplasmic translocation and release of IL-33 in airway epithelial cells by downregulating Nrf2

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Anti-Inflammatory Activity of Adenosine 5′-Trisphosphate in Lipopolysaccharide-Stimulated Human Umbilical Vein Endothelial Cells Through Negative Regulation of Toll-Like Receptor MyD88 Signaling

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ETV5-Mediated Transcriptional Repression of DDIT4 Blocks Macrophage Pro-Inflammatory Activation in Diabetic Atherosclerosis

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Single-cell transcriptomics of neuroinflammation and cerebrovascular endothelial cells in the aged rat hippocampus

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Eucommia ulmoides (Duzhong) extract alleviates cerebral stroke by inhibiting ferroptosis-related gene DNA Damage-Inducible Transcript 4 (DDIT4) expression

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Structural Characterization and Biological Activity of Oligopeptides from Isochrysis zhanjiangensis: Based on Quantum Mechanics, Molecular Docking and in Vitro Experiments

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Autophagy, apoptosis, and inflammation response of Sebastiscus marmoratus to different concentrations of hydroxychloroquine

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Complex IIa formation and ABC transporters determine sensitivity of OSCC to Smac mimetics

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Cyr61 Mediates Angiotensin II-Induced Podocyte Apoptosis via the Upregulation of TXNIP

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Research on the conversion pattern of 6-gingerol in stir-fried ginger and the protective activity mechanism of its conversion products on HUVECs

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Dapagliflozin Attenuates Atherosclerosis Under Chronic Stress by Maintaining AKT / FoxO1 Pathway Through Downregulation of REDD1

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Protective Effect of Raspberry Ketone on Deep Vein Thrombosis and the Molecular Mechanism

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Molecular Mechanism of SOX18 in Lipopolysaccharide-Induced Injury of Human Umbilical Vein Endothelial Cells

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TXNIP in liver sinusoidal endothelial cells ameliorates alcohol-associated liver diseasePreprint

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Mechanism of glucocorticoid receptor activation regulated expression of thrombospondin-1Preprint

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Salmonella Typhimurium L Forms Induce Vascular Endothelial Cell Apoptosis via Mitochondrial-dependent PathwayPreprint

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Salmonella Typhimurium L Forms Induce Vascular Endothelial Cell Apoptosis via Mitochondrial-Dependent PathwayPreprint

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Treatment of renal interstitial fibrosis with an agonistic Tie2 monoclonal antibody via amelioration of peritubular capillary lesions in a mouse model of nephropathyPreprint

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Additional file 4 of Small extracellular vesicles-transported lncRNA TDRKH-AS1 derived from AOPPs-treated trophoblasts initiates endothelial cells pyroptosis through PDIA4/DDIT4 axis in preeclampsia

Chen, Q., He, J., Liu, H., Huang, Q., Wang, S., Yin, A., Chen, S., Shen, X., Xiao, Y., Hu, H., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23740683

Additional file 3 of Small extracellular vesicles-transported lncRNA TDRKH-AS1 derived from AOPPs-treated trophoblasts initiates endothelial cells pyroptosis through PDIA4/DDIT4 axis in preeclampsia

Chen, Q., He, J., Liu, H., Huang, Q., Wang, S., Yin, A., Chen, S., Shen, X., Xiao, Y., Hu, H., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23740680

Additional file 2 of Small extracellular vesicles-transported lncRNA TDRKH-AS1 derived from AOPPs-treated trophoblasts initiates endothelial cells pyroptosis through PDIA4/DDIT4 axis in preeclampsia

Chen, Q., He, J., Liu, H., Huang, Q., Wang, S., Yin, A., Chen, S., Shen, X., Xiao, Y., Hu, H., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23740674

Additional file 5 of Small extracellular vesicles-transported lncRNA TDRKH-AS1 derived from AOPPs-treated trophoblasts initiates endothelial cells pyroptosis through PDIA4/DDIT4 axis in preeclampsia

Chen, Q., He, J., Liu, H., Huang, Q., Wang, S., Yin, A., Chen, S., Shen, X., Xiao, Y., Hu, H., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23740686

Additional file 7 of Small extracellular vesicles-transported lncRNA TDRKH-AS1 derived from AOPPs-treated trophoblasts initiates endothelial cells pyroptosis through PDIA4/DDIT4 axis in preeclampsia

Chen, Q., He, J., Liu, H., Huang, Q., Wang, S., Yin, A., Chen, S., Shen, X., Xiao, Y., Hu, H., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23740692

REDD1 upregulation via AP‐1 alleviates oxidative stress‐mediated liver injury

Ki, S. H., Cho, S. S., Kim, J. K., & Cho, I. J. (2019) · The FASEB Journal · doi:10.1096/fasebj.2019.33.1_supplement.506.4

Induction of REDD1 via AP-1 prevents oxidative stress-mediated injury in hepatocytes

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Regulated in Development and DNA Damage Response 1 Knockdown Alleviates Lipopolysaccharide-Induced Acute Lung Injury

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Antagonism of receptor interacting protein 1 using necrostatin-1 in oxidized LDL- induced endothelial injury

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Thioredoxin-Interacting Protein Mediates TRX1 Translocation to the Plasma Membrane in Response to Tumor Necrosis Factor-α

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