Cited by 249Muscle Physiology and DisordersExercise and Physiological ResponsesMuscle metabolism and nutrition

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TNF-α is a mitogen in skeletal muscle

Li, Yi-Ping·2003·American Journal of Physiology-Cell Physiology

DOI 10.1152/ajpcell.00453.2002

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Abstract

Emerging evidence suggests that tumor necrosis factor (TNF)-alpha plays a role in muscle repair. To determine whether TNF-alpha modulates satellite cell proliferation, the current study evaluated TNF-alpha effects on DNA synthesis in primary myoblasts and on satellite cell activation in adult mouse muscle. Exposure to recombinant TNF-alpha increased total DNA content in rat primary myoblasts dose-dependently over a 24-h period and increased the number of primary myoblasts incorporating 5-bromo-2'-deoxyuridine (BrdU) during a 30-min pulse labeling. Systemic injection of TNF-alpha stimulated BrdU incorporation by satellite cells in muscles of adult mice, whereas no BrdU was incorporated by satellite cells in control mice. TNF-alpha stimulated serum response factor (SRF) binding to the serum response element (SRE) present in the c-fos gene promoter and stimulated reporter gene expression controlled by the same element. Our data suggest that TNF-alpha activates satellite cells to enter the cell cycle and accelerates G1-to-S phase transition, and these actions may involve activation of early response genes via SRF.

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Authors: Li, Y.-P.
Affiliations: Baylor College of Medicine (US)
Corresponding author: Li, Yi-Ping
ORCID: Li, Yi-Ping
Venue: American Journal of Physiology-Cell Physiology
Publisher: American Physiological Society
Published: 2003-08
Volume: 285
Issue: 2
Pages: C370-C376
ISSN: 0363-6143 (ISSN-L)
1522-1563
DOI: 10.1152/ajpcell.00453.2002
OpenAlex: W1972955532
Cited by: 249
References: 56
Citations by year: 2026: 8 · 2025: 9 · 2024: 11 · 2023: 8 · 2022: 13 · 2021: 15 · 2020: 13 · 2019: 13 · 2018: 11 · 2017: 13 · 2016: 11 · 2015: 14 · 2014: 17 · 2013: 11 · 2012: 12
FWCI: 3.10
Type: journal article
Language: en
Open access: closed
Locations: American Journal of Physiology-Cell Physiology (publishedVersion)
PubMed (publishedVersion)
Funders: National Heart, Lung, and Blood Institute (HL59878, R01HL059878)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
Keywords: TNF-α, satellite cells, skeletal muscle, muscle repair, myoblast proliferation, DNA synthesis, cell cycle, G1/S transition, serum response factor, serum response element, c-fos promoter, early response genes, mitogens
MeSH terms: Animals, Animals, Newborn, Cell Division, Cells, Cultured, DNA, Dose-Response Relationship, Drug, Male, Mice, Inbred ICR, Promoter Regions, Genetic, Regeneration, Tumor Necrosis Factor-alpha, Proto-Oncogene Proteins c-fos, Genes, Reporter, Muscle, Skeletal, Serum Response Factor, Serum Response Element, Myoblasts, Satellite Cells, Skeletal Muscle, Mice, Rats

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TNF-α is a mitogen in skeletal muscle

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